Michael J Sailor

US Patent:

6734000, May 11, 2004

Filed:

Oct 12, 2001

Appl. No.:

09/981691

Inventors:

Vicki I. Chin - La Jolla CA
Sangeeta N. Bhatia - La Jolla CA
Michael J. Sailor - La Jolla CA
Boyce E. Collins - La Jolla CA

Assignee:

Regents of the University of California - Oakland CA

International Classification:

C12M 1114

US Classification:

435176, 435 29, 435 711, 435 712, 4352831, 435395

Abstract:

A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients such as by perfusion of the nanoporous silicon support with fluid. The macropores may be between 0. 2 and 200 microns and be coated with a substance that provides cell adhesion. The support containing cells may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. The support is sufficiently robust that it may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.

US Patent:

7042570, May 9, 2006

Filed:

Jan 9, 2003

Appl. No.:

10/339163

Inventors:

Michael J. Sailor - La Jolla CA, US
Sonia Letant - Livermore CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 21/55
C12M 1/34

US Classification:

356445, 4352871

Abstract:

A method for analyzing gaseous or liquid samples is provided. Samples are interacted with pores of a porous thin film. A time-varying response of reflectivity is obtained from the surface of the porous thin film during the interaction. One or more analytes forming the sample or a part of the sample are identified based upon the time-varying response.

US Patent:

7312046, Dec 25, 2007

Filed:

Feb 25, 2004

Appl. No.:

10/787015

Inventors:

Vicki I. Chin - La Jolla CA, US
Sangeeta N. Bhatia - La Jolla CA, US
Michael J. Sailor - La Jolla CA, US
Boyce E. Collins - La Jolla CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12Q 1/02
C12Q 1/18
C12Q 1/20
C12N 1/00
C12N 5/00
C12M 1/00
C12M 3/00

US Classification:

435 29, 435 32, 435 33, 435243, 435395, 4352891

Abstract:

A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients by means such as perfusion of the nanoporous silicon support with fluid. The macropores may be between 0. 2 and 200 microns and be coated with a substance that promotes cell adhesion. The support containing cells may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. The supports are sufficiently robust that they may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.

US Patent:

7318903, Jan 15, 2008

Filed:

Aug 13, 2004

Appl. No.:

10/567917

Inventors:

Jamie R. Link - La Jolla CA, US
Michael J. Sailor - La Jolla CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C23F 1/00
B32B 3/00

US Classification:

216 2, 4283126

Abstract:

The invention is related to optical particles (), use of optical particles in sensing applications, and methods of fabricating optical particles that can target a desired analyte. The invention is also related to the self assembly of individual optical particles. An advantage of the invention is that it includes self-assembling individual photonic crystal sensors onto a target. In an embodiment of the invention, a processed sensor structure having two generally opposing surfaces is provided, wherein each of the opposing surfaces have different surface affinities, with a first optical structure formed on one of the opposing surfaces, and a second optical structure formed on the other of the opposing surfaces. The chemically and optically asymmetric opposing surfaces will spontaneously align at an organic liquid/water interface. Changes in the optical response of at least one of the opposing surfaces indicate the presence of a particular analyte for sensing applications.

US Patent:

7433811, Oct 7, 2008

Filed:

May 4, 2004

Appl. No.:

10/838859

Inventors:

Jun Gao - Kingston, CA
Michael J. Sailor - La Jolla CA, US
Sangeeta Bhatia - La Jolla CA, US
Christopher Flaim - Modesto CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G06F 17/50
C23C 20/00

US Classification:

703 12, 716 21, 205 67

Abstract:

The invention is directed to methods for direct patterning of silicon. The invention provides the ability to fabricate complex surfaces in silicon with three dimensional features of high resolution and complex detail. The invention is suitable, for example, for use in soft lithography as embodiments of the invention can quickly create a master for use in soft lithography. In an embodiment of the invention, electrochemical etching of silicon, such as a silicon wafer, for example, is conducted while at least a portion of the silicon surface is exposed to an optical pattern. The etching creates porous silicon in the substrate, and removal of the porous silicon layer leaves a three-dimensional structure correlating to the optical pattern.

US Patent:

7482168, Jan 27, 2009

Filed:

Sep 14, 2002

Appl. No.:

10/244053

Inventors:

Michael J. Sailor - La Jolla CA, US
William C Trogler - Del Mar CA, US
Honglae Sohn - Gwangju, KR
Rebecca M. Calhoun - Austin TX, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33/00
G01N 21/76

US Classification:

436172, 436106

Abstract:

A method to develop inexpensive inorganic polymeric sensors that can provide a sensitivity and selectivity for explosive nitroaromatic compounds. Selectivity is provided by the arrays of 12 different reactive fluorescent sensors to mimic the human olfactory system. The sensors are based on photoluminescence quenching of polymers containing metalloid-metalloid backbones such as Si—Si, Si—Ge, or Ge—Ge. The sensor employs a thin film of photoluminescent copolymers, which is stable in air, water, acids, common organic solvents, and even seawater containing bioorganisms. The detection method involves measurement of the quenching of photoluminescence of the polysilole by the analyte.

US Patent:

7684043, Mar 23, 2010

Filed:

Feb 28, 2007

Appl. No.:

11/680309

Inventors:

Jason R. Dorvee - Ithaca NY, US
Jamie R. Link - Arlington VA, US
Michael J. Sailor - La Jolla CA, US
Harold E. Hager - Bellevue WA, US
William D. Sherman - Kent WA, US

Assignee:

The Boeing Company - Chicago IL

International Classification:

G01N 21/49

US Classification:

356437, 356446

Abstract:

A system and method for free space, optical remote sensing of a potential threat agent using spectrally responsive sensor material. In one example the sensor material is formed by particles, which in one particular form are porous photonic crystals. The particles are dispersed into an area being monitored for the presence of the potential threat agent. A pair of lasers is used to generate optical light beams that are directed at the sensor particles after the particles have been dispersed. The light reflected by the sensor particles is then analyzed. The presence of the potential threat agent causes a shift in the spectral peak of light reflected from the sensor particles that can be sensed using photo detectors and a processing subsystem. The system can be tuned to remotely detect for specific chemical, biological or environmental agents that may be present within a given area.

US Patent:

7713778, May 11, 2010

Filed:

Feb 13, 2004

Appl. No.:

10/544801

Inventors:

Yang Yang Li - Irvine CA, US
Frederique Cunin - 34250 Palavas les Flots, FR
Michael J. Sailor - La Jolla CA, US
Jamie R. Link - Arlington VA, US
Ting Gao - Sunnyvale CA, US

International Classification:

H01L 21/00

US Classification:

438 99, 977921, 438753

Abstract:

A method of generating three-dimensional nanostructures that includes providing a silicon substrate, creating a porous silicon template from the silicon substrate, wherein the template is created to have a predetermined configuration, depositing a predetermined material on the porous silicon template, and removing the porous silicon template from the deposited material to leave a freestanding nanostructure.