Michael J Salvatore

US Patent:

54119855, May 2, 1995

Filed:

May 17, 1993

Appl. No.:

8/062881

Inventors:

Gerald F. Bills - Cranford NJ
Otto D. Hensens - Red Bank NJ
Jerrold M. Liesch - Princeton Junction NJ
Russel B. Lingham - Watchung NJ
Jon D. Polishook - Scotch Plains NJ
Michael J. Salvatore - South Plainfield NJ
Susan L. Raghoobar - Fords NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3135

US Classification:

514460

Abstract:

Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1. beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e. g. , gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. ##STR1##.

US Patent:

40274063, Jun 7, 1977

Filed:

May 13, 1976

Appl. No.:

5/686126

Inventors:

Michael Salvatore - Greenwich CT

International Classification:

A43D 2100
A43B 0000

US Classification:

36 83

Abstract:

A lasting piece of shrinkable, preferably oriented thermoplastic polymeric material is attached, preferably by stitching, to a shoe upper lasting margin and is shrunk by being heated, if it is thermoplastic, to between its glass transition temperature and melting point. Shrinkage of the lasting piece lasts the shoe upper to the last. The lasting piece can be a lasting string, endless band or strip, or a sheet, web, net or welt. Lasted shoe uppers and articles of footwear are produced by the above method.