Michael F Schaffer

US Patent:

20040053230, Mar 18, 2004

Filed:

Aug 15, 2002

Appl. No.:

10/204889

Inventors:

Michael Schaffer - Boothwyn PA, US
Susan Tseng - Hockessin DE, US

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 702/020000

Abstract:

The PCR-based, dsDNA quantification method monitors the fluorescence of a target, whose melting characteristics is predetermined, during each amplification cycle at selected time-points. Fluorescence is measured immediately after the annealing phase (Fat T), immediately below (Fat T) and above (Fat T) the melting of the target/amplicon. A change in slope from a baseline slope (S=-(F-F)/(T-T)) to a melting phase slope (S=-(F-F)/(T-T) indicates a specific amplification. The number of amplification cycles (C) it takes for the quantity (S-S) to become greater than zero correlates with the starting concentration of the target (C). The concentration of the target in a sample is determined by comparing the value of Cfor the sample with a standard curve. By selecting targets with distinguishable melting curve characteristics, multiple targets can be simultaneously detected.

US Patent:

20040175752, Sep 9, 2004

Filed:

Apr 21, 2004

Appl. No.:

10/829430

Inventors:

Michael Schaffer - Boothwyn PA, US
Susan Tseng - Hockessin DE, US

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50
C12P019/34

US Classification:

435/006000, 702/020000, 435/091200

Abstract:

The PCR-based, dsDNA quantification method monitors the fluorescence of a target, whose melting characteristics is predetermined, during each amplification cycle at selected time-points. Fluorescence is measured immediately after the annealing phase (Fat T), immediately below (Fat T) and above (Fat T) the melting of the target/amplicon. A change in slope from a baseline slope (S=-(F-F)/(T-T)) to a melting phase slope (S=-(F-F)/(T-T) indicates a specific amplification. The number of amplification cycles (C) it takes for the quantity (S-S) to become greater than zero correlates with the starting concentration of the target (C). The concentration of the target in a sample is determined by comparing the value of Cfor the sample with a standard curve. By selecting targets with distinguishable melting curve characteristics, multiple targets can be simultaneously detected.

US Patent:

47809612, Nov 1, 1988

Filed:

Nov 10, 1986

Appl. No.:

6/928353

Inventors:

Russell S. Shelton - Flanders NJ
Michael J. Schaffer - Flanders NJ

International Classification:

G01B 702

US Classification:

33503

Abstract:

A probe assembly has a housing connected to the head of a coordinate measuring machine, a carrier movably connected to the housing, and a piezoelectric crystal mounted on the carrier. A stylus is mounted on the carrier. An electronic circuit receives signals from the crystal and, at an adjustable threshold value, the circuit provides output signals which are greater than and substantially simultaneous with signals from the crystal. A timer maintains the output signal for a time interval after the signal is produced by the crystal.

US Patent:

49247158, May 15, 1990

Filed:

Mar 9, 1989

Appl. No.:

7/321565

Inventors:

Michael J. Schaffer - Mendham NJ

Assignee:

Nawsir Inc. - Peapack NJ

International Classification:

G01B 702

US Classification:

738658

Abstract:

A contract sensing system is provided for a coordinate measuring machine which is manually operated. The system provides a control over the level of the sensing force of a work piece against a probe of the machine. The system also provides an instantaneous signal corresponding to the initial contact of the contacting force for avoiding displacement of the probe whereby the accuracy of the measurement is improved.

US Patent:

63033844, Oct 16, 2001

Filed:

Mar 3, 2000

Appl. No.:

9/517891

Inventors:

Susan P. Mills - Ambler PA
John A. Novinski - Leesburg FL
Michael I. Schaffer - Woodland Hills CA

Assignee:

Quest Diagnostics Investments, Inc. - San Juan Capistrano CA

International Classification:

G01N 3348

US Classification:

436111

Abstract:

This invention relates to a reagent and use of that reagent for detecting adulterants in aqueous samples, particularly in biological specimens such as urine samples using a diazo dye precursor such as N,N diethyl-1,4-phenylene diamine and a reagent such as creatinine to stabilize a colored intermediate formed by the reaction of the diamine with nitrite ions for a period sufficient to allow that color to be recorded and compared with a separate peak formed by a halogen-based oxidizing agent which may be present in solution.

US Patent:

20160304962, Oct 20, 2016

Filed:

Mar 11, 2016

Appl. No.:

15/067716

Inventors:

- BEERSE, BE
Shibu Thomas - North Wales PA, US
Michael Gormley - Mount Laurel NJ, US
Yashoda Rajpurohit - Hillsborough NJ, US
Michael Schaffer - Fort Washington PA, US

International Classification:

C12Q 1/68

Abstract:

Provided are whole blood based mRNA biomarkers for predicting prostate cancer and methods of detecting the same. The disclosed mRNA markers and methods enable the identification/diagnosis of a patient with prostate cancer, identification of a patient with/prediction of high-risk prostate cancer, and treatment of a patient with prostate cancer. Also provided are gene chips comprising the disclosed whole blood based mRNA biomarkers.

US Patent:

20150322523, Nov 12, 2015

Filed:

May 12, 2015

Appl. No.:

14/710093

Inventors:

- Beerse, BE
Weimin Li - Norristown PA, US
Michael Gormley - Mount Laurel NJ, US
Jayaprakash Karkera - Germantown MD, US
Michael Schaffer - Fort Washington MD, US

International Classification:

C12Q 1/68
A61K 31/573
A61K 31/58

Abstract:

Provided herein are methods of predicting a likelihood of survival following treatment with AA and prednisone in a patient having CRPC.