Michael J Sherman

US Patent:

7087583, Aug 8, 2006

Filed:

Mar 22, 2001

Appl. No.:

09/813824

Inventors:

Bert Vogelstein - Baltimore MD, US
Kenneth W. Kinzler - BelAir MD, US
Michael I. Sherman - Glen Ridge NJ, US

Assignee:

Johns Hopkins University - Baltimore MD
Genzyme Corporation - Cambridge MA

International Classification:

A61K 31/711

US Classification:

514 44

Abstract:

Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.

US Patent:

20100261177, Oct 14, 2010

Filed:

Sep 17, 2008

Appl. No.:

12/676053

Inventors:

Michael P. Weiner - Guilford CT, US
Michael I. Sherman - Glen Ridge NJ, US

Assignee:

AFFOMIX CORPORATION - New Haven CT

International Classification:

C12Q 1/68
C12N 1/21
C12N 5/10
C12N 1/19

US Classification:

435 6, 4352523, 435325, 4352542, 435348

Abstract:

To increase the efficiency of the selection of antibodies of desired specificity, we create multi-bait strain(s) in which one bait is the target and one or more bait(s) are non-target. The non-target bait(s) may use one or more DNA-binding domain(s) that differ(s) from that of the target bait and thereby activate one or more different reporters from that activated by the target bait. Library hits that activate both sets of reporters are presumed to be inadequately specific and can be eliminated from further consideration. Alternatively, a non-target bait may be replaced with a second target bait, and hits selected that activate both sets of reporters. Other combinations of elements can be used.

US Patent:

20100305004, Dec 2, 2010

Filed:

Sep 26, 2008

Appl. No.:

12/679586

Inventors:

Michael P. Weiner - Guilford CT, US
Michael I. Sherman - Glen Ridge NJ, US

Assignee:

AFFOMIX CORPORATION - Branford CT

International Classification:

C40B 50/06
C07K 14/00
C12N 9/00
G01N 33/50

US Classification:

506 26, 530358, 435183, 435 71

Abstract:

We use the Tus-Ter interaction to enable the utilization of nucleic acid analytical methodologies for proteins. We also use the Tus-Ter interaction to make polymers and oligomers that have a nucleic acid backbone with protein functionalities. These methods are useful for molecular modeling, for efficiently running enzymatic pathway reactions, and for analyzing presence and/or amount of particular proteins.

US Patent:

53626230, Nov 8, 1994

Filed:

Mar 31, 1992

Appl. No.:

7/860758

Inventors:

Bert Vogelstein - Baltimore MD
Kenneth W. Kinzler - Baltimore MD
Michael I. Sherman - Glen Ridge NJ

Assignee:

The John Hopkins University - Baltimore MD
PharmaGenics, Inc. - Allendale NJ

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.

US Patent:

6245515, Jun 12, 2001

Filed:

Sep 21, 1999

Appl. No.:

9/399773

Inventors:

Bert Vogelstein - Baltimore MD
Kenneth W. Kinzler - BelAir MD
Michael I. Sherman - Allendale NJ

Assignee:

The Johns Hopkins University - Baltimore MD
Pharmagenics, Incs - Allendale NJ

International Classification:

C12Q 168
C07H 2100
C07H 2102
C07H 2104
C07H 1900

US Classification:

435 6

Abstract:

Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.

US Patent:

59552638, Sep 21, 1999

Filed:

Sep 1, 1994

Appl. No.:

8/299074

Inventors:

Bert Vogelstein - Baltimore MD
Kenneth W. Kinzler - Baltimore MD
Michael I. Sherman - Glen Ridge NJ

Assignee:

Johns Hopkins University - Baltimore MD
Genzyme Corporation - Framingham MA

International Classification:

C12Q 168
G01N 33574
G01N 3348
C07H 2102

US Classification:

435 6

Abstract:

Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.

US Patent:

20220347606, Nov 3, 2022

Filed:

Jul 18, 2022

Appl. No.:

17/867141

Inventors:

- West Haven CT, US
George Lauri - Windsor CT, US
Stephen P. Huda - Shelton CT, US
Michael J. Sherman - Woodbury MN, US
Steven J. Haehn - Oakdale MN, US
Erik R. Klimpel - Woodbury MN, US
Will Anniss - Simpsonville SC, US
Willard Grant - Williamston SC, US
Raony Barrios - Anderson SC, US
William Small - Belton SC, US
Marcello Correa Machado - Anderson SC, US
Thomas W. McCollough - Anderson SC, US
Christopher Rousey - Anderson SC, US
Ramesh Subramanian - Charlotte NC, US

International Classification:

B01D 35/14
B01D 35/30
B01D 29/96

Abstract:

A filter housing assembly for fluid filtration which may be attached to, and removed from, a filter base by a push-actuated release. The filter housing assembly has a top portion with an ingress port and egress port extending therefrom, and a protrusion extending from the filter housing longitudinally axial center. The ingress and egress port are formed in an hourglass shape. A filter key having a base with a groove for mating with said projection, at least one finger extending from said base, and an electronic circuit component housing attached thereto for receiving a printed circuit board, is connected to the filter housing top portion by mating said top portion protrusion with the filter key groove. Both of said ingress and egress port have at least one cavity for the passage of fluid therethrough, where each cavity is exposed in a direction facing away from the printed circuit board.

US Patent:

20210236968, Aug 5, 2021

Filed:

Feb 24, 2021

Appl. No.:

17/183718

Inventors:

- West Haven CT, US
George Lauri - Windsor CT, US
Stephen P. Huda - Shelton CT, US
Michael J. Sherman - Woodbury MN, US
Steven J. Haehn - Oakdale MN, US
Erik R. Klimpel - Woodbury MN, US
Will Anniss - Simpsonville SC, US
Willard Grant - Williamston SC, US
Raony Barrios - Anderson SC, US
William Small - Belton SC, US
Marcello Correa Machado - Anderson SC, US
Thomas W. McCollough - Anderson SC, US
Christopher Rousey - Anderson SC, US
Ramesh Subramanian - Charlotte NC, US

International Classification:

B01D 35/14
B01D 35/30
B01D 29/96

Abstract:

A filter housing assembly for fluid filtration which may be attached to, and removed from, a filter base by a push-actuated release. The filter housing assembly has a top portion with an ingress port and egress port extending therefrom, and a protrusion extending from the filter housing longitudinally axial center. The ingress and egress port are formed in an hourglass shape. A filter key having a base with a groove for mating with said projection, at least one finger extending from said base, and an electronic circuit component housing attached thereto for receiving a printed circuit board, is connected to the filter housing top portion by mating said top portion protrusion with the filter key groove. Both of said ingress and egress port have at least one cavity for the passage of fluid therethrough, where each cavity is exposed in a direction facing away from the printed circuit board.