Michael Allen Snyder

US Patent:

8399383, Mar 19, 2013

Filed:

May 4, 2001

Appl. No.:

09/849781

Inventors:

Michael Snyder - Fairfield CT, US
Mark Reed - Monroe CT, US
Heng Zhu - New Haven CT, US
James Frank Klemic - New Haven CT, US

Assignee:

Yale University - New Haven CT

International Classification:

C40B 40/02
C40B 40/10

US Classification:

506 14, 506 13, 436 86, 436518, 436527, 4352884

Abstract:

The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention also relates to methods of using the protein chips for high density and small volume chemical reactions. Also, the invention relates to polymers useful as protein chip substrates and methods of making protein chips. The invention further relates to compounds useful for the derivatization of protein chip substrates.

US Patent:

20050182242, Aug 18, 2005

Filed:

May 13, 2002

Appl. No.:

10/477329

Inventors:

Michael Snyder - Fairfield CT, US
Paul Bertone - Hamden CT, US
Scott Bidlingmaier - Walnut Creek CA, US
Metin Bilgin - New Haven CT, US
Antonio Casamayor - Cerdanyola, ES
Mark Gerstein - North Haven CT, US
Ronald Jansen - New York NY, US
Ning Lan - Norwalk CT, US

International Classification:

C07K001/00
A61K038/00
C07K017/00
G01N033/50
C12N001/00

US Classification:

530350000, 530300000, 530333000, 435007100, 435243000

Abstract:

The present invention relates to proteome chips comprising arrays having a large proportion of all proteins expressed in a single species. The invention also relates to methods for making proteome chips. The invention also relates to methods for using proteome chips to systematically assay all protein interactions in a species in a high-throughput manner. The present invention also relates to methods for making and purifying eukaryotic proteins in a high-density array format. The invention also relates to methods for making protein arrays by attaching double-tagged fusion proteins to a solid support. The invention also relates to a method for identifying whether a signal is positive.

US Patent:

20080145364, Jun 19, 2008

Filed:

Feb 15, 2006

Appl. No.:

11/816074

Inventors:

Sherman M. Weissman - New Haven CT, US
Michael Snyder - New Haven CT, US

International Classification:

A61K 39/395
C40B 30/06
C07K 16/18
A61P 43/00
A61K 38/00
C07K 1/00

US Classification:

4241381, 506 10, 5303877, 530300, 514 2

Abstract:

High throughput assays used to identify antibodies and proteins that induce cell death are described herein. It is not necessary to identify the antigens the antibodies are reactive with prior to performing the assays. Instead, libraries of antibodies and proteins, including murine, human, humanized, single chain, and synthetic antibodies, are screened using high throughput assays to identify those antibodies and proteins which cause cell death. Standard technology is then used to screen for cell viability. Antibodies and proteins which induce apoptosis preferentially or exclusively of cancer cells are then isolated, characterized, and may be cloned. A method for cloning antibodies and proteins has been developed, which provides means for rapid identification of the antibody or protein and the gene encoding the antibody or protein, based on the presence of a “bar code” or “unique sequence.” A method for high throughput production of antibodies to human proteins has also been developed.

US Patent:

20090305259, Dec 10, 2009

Filed:

Mar 21, 2007

Appl. No.:

12/281767

Inventors:

Joseph Madri - North Branford CT, US
Anjali Nath - Guilford CT, US
Michael Krauthammer - New Haven CT, US
Michael Snyder - Fairfield CT, US
Eugene Davidov - Hamden CT, US

Assignee:

YALE UNIVERSITY - New Haven CT

International Classification:

C12Q 1/68
G01N 33/53
G01N 33/00
C12Q 1/54
C12Q 1/37
C12Q 1/02

US Classification:

435 6, 435 71, 435 792, 435 14, 435 23, 435 29

Abstract:

The present invention relates to the identification of a series of biomarkers, the detection of which is prognostic for women at risk of becoming hyperglycemic during pregnancy and/or fetuses at risk of developing congenital anomalies as a result of maternal hyperglycemia.

US Patent:

20110076253, Mar 31, 2011

Filed:

Jul 28, 2006

Appl. No.:

11/989363

Inventors:

Michael P. Snyder - Fairfield CT, US
Joyce J. Lu - New Haven CT, US

International Classification:

A61K 35/12
C12N 5/071
C12N 5/0735

US Classification:

424 937, 435406, 435366, 435325, 435408, 435407

Abstract:

The present invention relates to compositions and methods for culturing stem cells, particularly embryonic stem cells. Specifically, the invention relates to a culture medium that supports proliferation of substantially undifferentiated stem cells, while maintaining potency of the cells. An an embodiment, the culture medium is defined and supports proliferation of substantially undifferentiated embryonic stem cells in essentially serum free and feeder cell free conditions. Compositions for making the medium and methods using the culture medium are also provided.

US Patent:

20140235507, Aug 21, 2014

Filed:

Mar 15, 2013

Appl. No.:

13/840960

Inventors:

Michael Snyder - Fairfield CT, US
Mark Reed - Monroe CT, US
Heng Zhu - New Haven CT, US
James Frank Klemic - New Haven CT, US

Assignee:

Yale University - New Haven CT

International Classification:

C12Q 1/48

US Classification:

506 18

Abstract:

The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention also relates to methods of using the protein chips for high density and small volume chemical reactions. Also, the invention relates to polymers useful as protein chip substrates and methods of making protein chips. The invention further relates to compounds useful for the derivatization of protein chip substrates.

US Patent:

20140096977, Apr 10, 2014

Filed:

Oct 4, 2012

Appl. No.:

13/644914

Inventors:

- Houston TX, US
David Lawrence Ford - Houston TX, US
Michael Benjamin Snyder - Houston TX, US

Assignee:

Vetco Gray Inc. - Houston TX

International Classification:

E21B 41/00

US Classification:

166379, 166 7511

Abstract:

A wellhead seal assembly that forms a metal-to-metal seal between inner and outer wellhead members. A seal member has inner and outer seal legs separated by a slot. A locking ring is positioned in the outer seal leg and has wickered sections, where each of the wickered sections protrude through a window in the outer seal leg of the seal member. An energizing ring has an upper tapered surface that is oblique to an axis of the annular energizing ring and extending laterally from the axis over a portion of the locking ring and a lower tapered surface that is oblique to and extending laterally from the axis. As the energizing ring is moved into the slot, the upper tapered surface engages an inner surface of the locking ring, and the lower tapered surface engages an inner annular wall of the slot.

Address:

10903 Highland Mdw Vlg Dr, Houston, TX 77089

VIN:

1G1AL55F277252221

Make:

CHEVROLET

Model:

COBALT

Year:

2007

Address:

709 Worthshire St, Houston, TX 77008

VIN:

5Y2SL65887Z425991

Make:

PONTIAC

Model:

VIBE

Year:

2007