Adair J. Hotchkiss - Half Moon Bay CA John V. O'Connor - San Carlos CA Michael W. Spellman - San Bruno CA
Assignee:
Genentech, Inc. - So. San Francisco CA
International Classification:
A61K 3849 C07K 14435 C12N 948
US Classification:
424 9464
Abstract:
Novel human tissue-type plasminogen activator variant that a) retains substantially full biological activity b) has a modified carbohydrate structure and c) has an altered in vivo half-life. Means for preparation of the variants and results of assays measuring function of the activators are also disclosed.
Adair J. Hotchkiss - Half Moon Bay CA John V. O'Connor - San Carlos CA Michael W. Spellman - San Bruno CA
Assignee:
Genentech, Inc. - San Bruno CA
International Classification:
A61K 3849 C12N 1558
US Classification:
435 691
Abstract:
Novel human tissue-type plasminogen activator variant that a) retains substantially full biological activity b) has a modified carbohydrate structure and c) has an altered in vivo half-life. Means for preparation of the variants and results of assays measuring function of the activators are also disclosed.
Vincent Althaus, Harry Adrian, Richard Geimer, Francis Nichols, Bill Gregory, Jack Hanses, Thomas Hennessy, Richard Puhl, Thomas Carney, Thomas Kelly, John Cull, Richard Mann