Michael J West

US Patent:

6391554, May 21, 2002

Filed:

Nov 23, 1999

Appl. No.:

09/447151

Inventors:

Michael D. West - Boston MA
Jerry W. Shay - Dallas TX
Woodring E. Wright - Dallas TX
Nam Woo Kim - San Jose CA
Calvin B. Harley - Palo Alto CA
Scott L. Weinrich - Redwood City CA

Assignee:

Geron Corporation and Board of Regents - Menlo Park CA
The University of Texas Systems - Austin TX

International Classification:

C12Q 168

US Classification:

435 6, 435 15, 435 912, 435 72

Abstract:

Methods and kits are provided for diagnosis of specific cancerous conditions. The invention features a method for diagnosis of a condition in a patient associated with an elevated level of telomerase activity within a cell. The method involves determining the presence or amount of telomerase within the cells in the patient, e. g. by the use of the polymerase chain reaction. In one embodiment of the invention, the condition associated with elevated telomerase activity is chosen from prostate cancer, breast cancer, colon cancer, renal cancer, ovarian/cervical cancer, lung cancer, and leukemia. The invention allows cancer to be detected even in tissues and cells which are not positive by pathology.

US Patent:

20020174449, Nov 21, 2002

Filed:

Mar 25, 2002

Appl. No.:

10/103806

Inventors:

Michael West - Boston MA, US
Jose Cibelli - Holden MA, US

International Classification:

A01K067/027

US Classification:

800/015000, 800/021000, 800/019000

Abstract:

The present invention concerns the use of chromosomal replacement techniques in the context of producing cloned and transgenic animals, in order to correct chromosome abnormalities or alter autosomal genotypes, and provide for novel breeding pairs by replacing the sex chromosome in animals to be cloned. Replacement of a sex chromosome, or an X or Y chromosome, will result in animals that are autosomally isogenic and sexually non-isogenic (AISN), with “autosomally isogenic” meaning that the paired sets of autosomes (non-sex chromosomes) in each animal are isogenic or identical. Also included in the invention are animals that are both “autosomally” and “allelically” isogenic whereby each particular pair of chromosomes is internally isogenic or identical within a single animal as well as between animals. Such animals are particularly useful in generating a line of cloned mammals using sexual reproduction, without having to undergo nuclear transfer in order to propagate cloned animals.

US Patent:

20040040050, Feb 26, 2004

Filed:

Jun 6, 2003

Appl. No.:

10/276001

Inventors:

Michael West - Boston MA, US

International Classification:

A01K067/027
G06F017/60

US Classification:

800/014000, 800/019000, 705/001000, 119/300000

Abstract:

This invention describes a novel method of agricultural animal production that provides animals with optimum growth characteristics in a reliable and cost-effective manner. The invention utilizes a novel combination of Nuclear Transfer (NT) and Embryonic Stem (ES) cell technologies that improves the efficiency of delivering optimized animals and facilitates the introduction of genetic modifications into farm animals.

US Patent:

20040180430, Sep 16, 2004

Filed:

Mar 1, 2004

Appl. No.:

10/790640

Inventors:

Michael West - Boston MA, US
Jose Cibelli - Holden MA, US
Robert Lanza - Clinton MA, US

International Classification:

C12N005/08

US Classification:

435/366000

Abstract:

This invention relates to methods for rejuvenating primary cells and for making primary cells of a different type having the same genotype as a primary cell of interest. Also encompassed are methods of re-cloning cloned mammals, particularly methods where the offspring of cloned mammals are designed to be genetically altered in comparison to their cloned parent. Also included are methods for activating endogenous telomerase for the purpose of extending the life span of a primary cell.

US Patent:

20050255596, Nov 17, 2005

Filed:

Mar 9, 2005

Appl. No.:

11/079930

Inventors:

Michael West - Boston MA, US
Robert Lanza - Clinton MA, US
Jose Cibelli - Holden MA, US

International Classification:

C12Q001/68
C12N015/63
C12N005/08
C12N015/85

US Classification:

435455000, 435366000

Abstract:

This invention relates to methods for rejuvenating normal somatic cells and for making normal somatic cells of a different type having the same genotype as a normal somatic cell of interest. These cells have particular application in cell and tissue transplantation. Also encompassed are methods of re-cloning cloned animals, particularly methods where the offspring of cloned mammals are designed to be genetically altered in comparison to their cloned parent, e.g., that are “hyper-young.” These animals should be healthier and possess desirable properties relative to their cloned parent. Also included are methods for activating endogenous telomerase, EPC-1 activity, and or the ALT pathway and/or extending the life-span of a normal somatic cell, and other genes associated with cell aging and proliferation capacity.

US Patent:

20120196769, Aug 2, 2012

Filed:

Dec 23, 2011

Appl. No.:

13/336755

Inventors:

Michael D. West - Boston MA, US
Robert Lanza - Clinton MA, US
Jose Cibelil - Holden MA, US

International Classification:

C12N 5/071
A61B 17/425
C12N 5/10
C40B 30/06
C12Q 1/48

US Classification:

506 10, 435375, 435366, 435350, 435351, 435354, 435353, 435352, 435 15, 600 33

Abstract:

This invention relates to methods for rejuvenating normal somatic cells and for making normal somatic cells of a different type having the same genotype as a normal somatic cell of interest. These cells have particular application in cell and tissue transplantation. Also encompassed are methods of re-cloning cloned animals, particularly methods where the offspring of cloned mammals are designed to be genetically altered in comparison to their cloned parent, e.g., that are “hyper-young.” These animals should be healthier and possess desirable properties relative to their cloned parent. Also included are methods for activating endogenous telomerase, EPC-1 activity, and or the ALT pathway and/or extending the life-span of a normal somatic cell, and other genes associated with cell aging and proliferation capacity.