Alan DiSpirito - Ames IA, US James Zahn - Harbor Beach MI, US David Graham - Lawrence KS, US Hyung Kim - St. Paul MN, US Michail Alterman - Lawrence KS, US Cynthia Larive - Lawrence KS, US
International Classification:
A61K038/08
US Classification:
514/006000, 530/329000
Abstract:
A means and method for treating bacterial infection, providing antioxidant activity, and chelating copper using a copper binding compound produced by methanotrophic bacteria is described. The compound, known as methanobactin, is the first of a new class of antibiotics having gram-positive activity. Methanobactin has been sequenced, and its structural formula determined.
Analysis Of Protein Isoforms Using Unique Tryptic Peptides By Mass Spectrometry And Immunochemistry
Michail Alterman - Bethesda MD, US Boris Kornilayev - Lawrence KS, US
International Classification:
C12Q 1/37
US Classification:
435023000
Abstract:
A method for qualitatively and quantitatively detecting a protein isoform (p450 isozyme) in a sample using MALDI-TOF mass spectrometry or immunochemistry using a unique proteolytic peptide for the isoform. Relative and absolute quantitation can be performed using calibration curves with P450 isozyme-specific peptide standards.