Michelle J Martinez

US Patent:

8420622, Apr 16, 2013

Filed:

Dec 14, 2007

Appl. No.:

12/520132

Inventors:

Benito Munoz - Newtonville MA, US
Jed Hubbs - Cambridge MA, US
Christopher L. Hamblett - Boston MA, US
Hua Zhou - Waltham MA, US
Michelle Martinez - Salem MA, US

Assignee:

Merck, Sharp & Dohme, Corp. - Rahway NJ

International Classification:

A61K 31/445
C07F 7/10

US Classification:

514 63, 514317, 514326, 546 14, 546210, 546237

Abstract:

Compounds of formula I: I wherein at least one of R4 and R5 comprises Si(R6)3 as a substituent selectively attenuate production of Aβ(1-42) and hence find use in treatment of Alzheimer's disease and related conditions.

US Patent:

8592383, Nov 26, 2013

Filed:

Jun 14, 2012

Appl. No.:

13/523354

Inventors:

Xianhai Huang - Warren NJ, US
Jason Brubaker - Cambridge MA, US
Scott L. Peterson - Salem MA, US
John W. Butcher - Berlin MA, US
Joshua T. Close - Franklin MA, US
Michelle Martinez - Medford MA, US
Rachel Nicola MacCoss - Oxford, GB
Joon O. Jung - Newton MA, US
Phieng Siliphaivanh - Newton MA, US
Hongjun Zhang - Newton MA, US
Robert G. Aslanian - Rockaway NJ, US
Purakkattle Johny Biju - Piscataway NJ, US
Li Dong - Roselle Park NJ, US
Ying Huang - Berkeley Heights NJ, US
Kevin D. McCormick - Basking Ridge NJ, US
Anandan Palani - Bridgewater NJ, US
Ning Shao - Watchung NJ, US
Wei Zhou - Scotch Plains NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 221/16
C07D 401/10
C07D 413/10
A61K 31/473
A61K 31/501
A61K 31/506
A61K 31/5377
A61K 31/706
A61P 11/00
A61P 11/06
A61P 37/08
C07H 15/26

US Classification:

514 32, 51421018, 5142328, 51425204, 514256, 514290, 536 174, 544126, 544238, 544335, 546 79

Abstract:

The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I),.

US Patent:

20110251172, Oct 13, 2011

Filed:

Jul 31, 2009

Appl. No.:

13/058232

Inventors:

Alexey A. Rivkin - Boston MA, US
Sean P. Ahearn - Somerville MA, US
Stephanie M. Chichetti - Brookline MA, US
Christohpher L. Hamblett - Boston MA, US
Yudith Garcia - Brookline NY, US
Michelle Martinez - Medford MA, US
Benito Munoz - Newtonville MA, US

International Classification:

A61K 31/52
A61P 25/28
A61K 31/551
A61K 31/55
C07D 473/16
A61K 31/5377

US Classification:

51421018, 544277, 51426322, 51425216, 514249, 51421021, 544118, 5142342, 540575, 514218, 5142634, 544230, 540600, 51421706, 51426323, 540594, 51421701

Abstract:

The invention encompasses purine derivatives as gamma secretase modulators, useful for treating diseases associated with the deposition of beta-amyloid peptide in the brain, such as Alzheimer's disease, or of preventing or delaying the onset of dementia associated with such diseases. Pharmaceutical compositions and methods of use are included.

US Patent:

20130225577, Aug 29, 2013

Filed:

Oct 17, 2011

Appl. No.:

13/880767

Inventors:

David Joseph Guerin - Natick MA, US
Jason D. Brubaker - Cambridge MA, US
Michelle Martinez - Medford MA, US
Joon O. Jung - Newton MA, US
Neville J. Anthony - Northborough MA, US
Mark E. Scott - Andover MA, US
Carolyn Michele Cammarano - Worcestor MA, US
Dawn Marie Mampreian Hoffman - Boston MA, US
Hyun Chong Woo - Natick MA, US
Christopher J. Dinsmore - Newton MA, US
Philip Jones - Houston TX, US

International Classification:

C07D 471/04

US Classification:

5142342, 544280, 5142651, 544117

Abstract:

The instant invention provides compounds of formula I which are Jak inhibitors, and as such are useful for the treatment of Jak-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

US Patent:

60852453, Jul 4, 2000

Filed:

Jul 24, 1997

Appl. No.:

8/922722

Inventors:

Mahendra Kaycee - Freehold NJ
Ken Martinez - Tampa FL
Michelle Martinez - Clearwater FL
Sue Alfano - Lakeland FL
Rocco Sansone - Seminole FL

Assignee:

Paradyne Corporation - Largo FL

International Classification:

G06F 1130

US Classification:

709224

Abstract:

A digital subscriber line (DSL) remote terminal unit (RTU) using a plurality of forwarding policies and a management information base (MIB) allows the implicit support of IP subnetworks by creating dynamically, the routing tables necessary for IP subnetwork addressing. By using a constructed enterprise DSL ipInjection MIB to define a plurality of objects that describe the creation and management of a plurality of IP subnetworks the present invention allows the creation and support of both contiguous IP subnetworks and discontiguous IP subnetworks.

US Patent:

20160272632, Sep 22, 2016

Filed:

Mar 19, 2014

Appl. No.:

14/778046

Inventors:

Matthew Lloyd CHILDERS - Boston MA, US
Peter FULLER - Boston MA, US
David GUERIN - Natick MA, US
Jason David KATZ - Boston MA, US
Qinglin PU - Boston MA, US
Mark E. SCOTT - Boston MA, US
Christopher E. THOMPSON - Arlington MA, US
Michelle MARTINEZ - Watertown MA, US
Danielle FALCONE - Boston MA, US
Luis TORRES - Boston MA, US
Yongqi DENG - Boston MA, US
Ravi KURUKULASURIYA - Boston MA, US
Hongbo ZENG - Westford MA, US
Yunfeng BAI - Beijing, CN
Norman KONG - Beijing, CN
Yumei LIU - Beijing, CN
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 471/04
C07D 519/00

Abstract:

The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

US Patent:

20150353553, Dec 10, 2015

Filed:

Jan 29, 2014

Appl. No.:

14/762827

Inventors:

- Rahway, NJ, US
Matthew P. Christopher - Brookline MA, US
Christopher Dinsmore - Newton MA, US
Ronald J. Doll - Convent Station NJ, US
Francesc Xavier Fradera Llinas - Brookline MA, US
Chaomin Li - Boston MA, US
Michelle Machacek - Brookline MA, US
Michelle Martinez - Watertown MA, US
Latha G. Nair - Edison NJ, US
Weidong Pan - Somerset NJ, US
Michael Hale Reutershan - Brighton MA, US
Manami Shizuka - Lexington MA, US
Dietrich P. Steinhuebel - Boston MA, US
Binyuan Sun - Boston MA, US
Christopher Francis Thompson - Arlington MA, US
B. Wesley Trotter - Medfield MA, US
Yaolin Wang - Short Hills NJ, US
Liping Yang - Arlington MA, US
Stephane L. Bogen - Somerset NJ, US
Matthew E. Voss - Ville De West, SG
Jagannath Panda - , SG
Anthappan Tony Kurissery - , SG

Assignee:

MERCK SHARP & DOHME CORP. - Rahway NJ

International Classification:

C07D 473/34
C07D 473/16

Abstract:

The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.

US Patent:

20140357618, Dec 4, 2014

Filed:

Aug 21, 2014

Appl. No.:

14/465577

Inventors:

- Rahway NJ, US
Francesc Xavier Fradera Llinas - Brookline MA, US
Michelle Machacek - Brookline MA, US
Michelle Martinez - Watertown MA, US
Michael Hale Reutershan - Brighton MA, US
Manami Shizuka - Lexington MA, US
Binyuan Sun - Needham Heights MA, US
Christopher Francis Thompson - Arlington MA, US
B. Wesley Trotter - Medfield MA, US
Matthew E. Voss - Singapore, SG
Michael D. Altman - Needham MA, US
Stephane L. Bogen - Somerset NJ, US
Ronald J. Doll - Convent Station NJ, US

International Classification:

C07D 471/04
C07D 519/00

US Classification:

51421115, 5142305, 5142342, 51425304, 514278, 514303

Abstract:

The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.