Michelle S Morris

US Patent:

7700603, Apr 20, 2010

Filed:

Jun 9, 2005

Appl. No.:

11/149027

Inventors:

Zhaoning Zhu - Plainsboro NJ, US
Brian A McKittrick - New Vernon NJ, US
Yuanzan C Ye - Edison NJ, US
Johannes H Voigt - Cranford NJ, US
Corey Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham Township NJ, US
William J. Greenlee - Teaneck NJ, US
Robert Mazzola - Stewartsville NJ, US
John Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Tao Guo - Dayton NJ, US
Thuy X. H. Le - Monmouth Junction NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Rachael C. Hunter - Princeton NJ, US
Michelle L. Morris - Lawrenceville NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - East Windsor NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A01N 43/54
C07D 239/02
C07D 239/42
C07D 401/04

US Classification:

514256, 544320, 544321

Abstract:

Disclosed are compounds of the formula IAlso disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.

US Patent:

7763609, Jul 27, 2010

Filed:

Feb 23, 2007

Appl. No.:

11/710582

Inventors:

Zhaoning Zhu - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan C. Ye - Edison NJ, US
Johannes H. Voigt - Cranford NJ, US
Corey O. Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham Township NJ, US
William J. Greenlee - Teaneck NJ, US
Robert D. Mazzola - Stewartsville NJ, US
John P. Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Xiaoxiang Liu - River Vale NJ, US
Tao Guo - Dayton NJ, US
Thuy X. E. Le - Monmouth Junction NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Rachael C. Hunter - Princeton NJ, US
Michelle L. Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - East Windsor NJ, US
Ying Huang - East Brunswick NJ, US
Guoqing Li - Belle Mead NJ, US
Jianping Pan - Monmouth Junction NJ, US
Jeffrey A. Misiaszek - Kenilworth NJ, US
Gaifa Lai - Monmouth Junction NJ, US
Jingqi Duo - Monmouth Junction NJ, US
Chuanxing Qu - Scotch Plains NJ, US
Yuefei Shao - Princeton NJ, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia, LLC - San Diego CA

International Classification:

A61K 31/535
C07D 273/04

US Classification:

5142292, 544 66

Abstract:

Disclosed are compounds of the formula IAlso disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.

US Patent:

7973067, Jul 5, 2011

Filed:

Dec 10, 2008

Appl. No.:

12/331787

Inventors:

Zhaoning Zhu - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan C. Ye - North Brunswick NJ, US
Johannes H. Voigt - Cranford NJ, US
Corey Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham Township NJ, US
William J. Greenlee - Teaneck NJ, US
John P. Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Tao Guo - Dayton NJ, US
Thuy X. H. Le - Monmouth Junction NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Pennington NJ, US
Rachel C. Hunter - Wayne PA, US
Michelle L. Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - Avenel NJ, US

Assignee:

Schering Corporation - Rahway NJ

International Classification:

A01N 43/50
A61K 31/415
C07D 233/00

US Classification:

514389, 514391, 5483215

Abstract:

Disclosed are compounds of the formula IAlso disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.

US Patent:

8242112, Aug 14, 2012

Filed:

May 16, 2011

Appl. No.:

13/108454

Inventors:

Zhaoning Zhu - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan C. Ye - North Brunswick NJ, US
Johannes H. Voigt - Cranford NJ, US
Corey Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew W. Stamford - Chatham Township NJ, US
William J. Greenlee - Teaneck NJ, US
John P. Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Tao Guo - Dayton NJ, US
Thuy X. H. Le - Monmouth Junction NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Pennington NJ, US
Rachael C. Hunter - Wayne PA, US
Michelle L. Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - Avenel NJ, US

Assignee:

Schering Corporation - Rahway NJ
Pharmacopeia Drug Discovery, Inc. - La Jolla CA

International Classification:

A61K 31/535
C07D 273/04

US Classification:

5142292, 544 66

Abstract:

Disclosed are compounds of the formula IAlso disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.

US Patent:

8288371, Oct 16, 2012

Filed:

Oct 3, 2008

Appl. No.:

12/245305

Inventors:

Vidyadhar M. Paradkar - Somerville NJ, US
Marc Brescia - Cranbury NJ, US
Ray James - Bensalem NJ, US
Jinqi Liu - Plainsboro NJ, US
Ruiyan Liu - Yardley PA, US
James Robert Merritt - Ewing NJ, US
Michelle Morris - Lawrenceville NJ, US
Michael J. Ohlmeyer - Plainsboro NJ, US
Chongwu Zhang - Dayton NJ, US
Rui Zhang - Plainsboro NJ, US

Assignee:

Pharmacopeia, LLC - San Diego CA

International Classification:

A61K 31/4196
A61K 31/44
A61K 31/433
A61K 31/42
A61K 31/425
A61K 31/445
A61K 31/4164
A61K 31/40
A61K 31/505
A61K 31/4245
A61K 31/538
C07D 249/08
C07D 401/14
C07D 285/04
C07D 261/06
C07D 277/20
C07D 233/54
C07D 209/02
C07D 413/14
C07D 403/14
C07D 271/08

US Classification:

5142102, 5142312, 514269, 514326, 514362, 514364, 514365, 514378, 514340, 514383, 514385, 514414, 544132, 544141, 544333, 548134, 548143, 548202, 548247, 5482622, 5483001, 548465, 548950, 546208, 546210, 5462764, 5462684

Abstract:

Compounds of the formula.

US Patent:

8314091, Nov 20, 2012

Filed:

Aug 19, 2008

Appl. No.:

12/194146

Inventors:

Andrew Laird Roughton - Plainsboro NJ, US
Irina Neagu - Plainsboro NJ, US
Jui-Hsiang Chan - West Windsor NJ, US
Nasrin Ansari - Monmouth Junction NJ, US
Michelle Lee Morris - Lawrenceville NJ, US
Yajing Rong - Dayton NJ, US
Michael Ohlmeyer - Plainsboro NJ, US
Andrew John Cooke - Newhouse, GB
Andrew Stanley Edwards - Newhouse, GB
David Jonathan Bennett - Newhouse, GB

Assignee:

MSD OSS B.V. - Oss
Pharmacopeia, Inc. - Cranbury NJ

International Classification:

A01N 43/62
A01N 43/58
A01N 43/60
A61K 31/55
A61K 31/535
A61K 31/50
A61K 31/495
A61K 31/497
A61K 31/4965
C07D 243/00
C07D 487/22
C07D 491/00
C07D 498/00
C07D 243/08
C07D 413/00
C07D 239/02
C07D 241/36
C07D 271/00
C07D 487/00
C07D 495/00
C07D 497/00
C07D 513/00
C07D 417/00
C07D 419/00
C07D 241/02
C07D 403/00
C07D 411/00
C07D 295/00

US Classification:

514218, 5142315, 5142358, 514250, 51425211, 51425213, 51425301, 51425401, 51425405, 5142541, 514 2, 514 5411, 51425403, 51425501, 51425404, 540555, 540575, 544121, 544306, 544338, 544357, 544367, 544371, 544377, 544379, 544391, 544386

Abstract:

The present invention relates to N-benzyl,N′-arylcarbonylpiperazine derivatives having the general formula I.

US Patent:

20120231017, Sep 13, 2012

Filed:

Mar 8, 2012

Appl. No.:

13/415404

Inventors:

ZHAONING ZHU - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan C. Ye - Edison NJ, US
Johannes H. Voigt - Cranford NJ, US
Corey O. Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham NJ, US
William J. Greenlee - Teaneck NJ, US
Robert D. Mozzola - Stewartsville NJ, US
John P. Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Tao Guo - Dayton NJ, US
Thuy X. E. Le - Monmouth Junction NJ, US
Kurt W. Sainoz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Rachael C. Hunter - Princeton NJ, US
Michelle L. Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - East Windsor NJ, US
Ying Huang - East Brunswick NJ, US
Guoqing Li - Belle Mead NJ, US
Jianping Pan - Monmouth Junction NJ, US
Jeffrey A. Misiaszek - Kenilworth NJ, US
Gaifa Lai - Monmouth Junction NJ, US
Jingqi Duo - Monmouth Junction NJ, US
Chuanxing Qu - Scotch Plains NJ, US
Yuefei Shao - Princeton NJ, US

Assignee:

Pharmacopeia Inc. - La Jolla CA
Schering Corporation - Rahway NJ

International Classification:

A61K 39/395
C07D 239/70
C07F 5/02
C07D 403/10
A61K 31/513
A61K 31/506
C07D 409/04
C07D 409/14
C07D 401/04
C07D 405/14
C07D 417/14
C07D 417/04
C07D 413/14
C07D 413/10
A61K 31/5377
A61P 29/00
A61P 9/00
A61P 25/28
A61P 31/10
A61P 33/02
C07D 495/04
A61P 25/00
A61P 31/04
C07D 239/22

US Classification:

4241721, 544321, 544231, 544229, 514272, 544295, 51425505, 544123, 5142358, 5142102

Abstract:

Disclosed are compounds of the formula Ior a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.

US Patent:

20120231018, Sep 13, 2012

Filed:

Mar 9, 2012

Appl. No.:

13/416140

Inventors:

Zhaoning Zhu - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan C. Ye - Edison NJ, US
Johannes H. Voigt - Cranford NJ, US
Corey O. Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham NJ, US
William J. Greenlee - Teaneck NJ, US
Robert D. Mozzola - Stewartsville NJ, US
John P. Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Xiaoxiang Liu - River Vale NJ, US
Tao Guo - Dayton NJ, US
Thuy X. E. Le - Monmouth Junction NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Rachael C. Hunter - Princeton NJ, US
Michelle L. Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - East Windsor NJ, US
Ying Huang - East Brunswick NJ, US
Guoqing Li - Belle Mead NJ, US
Jianping Pan - Monmouth Junction NJ, US
Jeffrey A. Misiaszek - Kenilworth NJ, US
Gaifa Lai - Monmouth Junction NJ, US
Jingqi Duo - Monmouth Junction NJ, US
Chuanxing Qu - Scotch Plains NJ, US
Yuefei Shao - Princeton NJ, US

Assignee:

Pharmacopeia Inc. - La Jolla CA
Schering Corporation - Rahway NJ

International Classification:

A61K 31/513
A61P 25/28
A61P 31/10
A61P 25/00
A61P 29/00
A61K 39/395
A61P 31/04
A61P 9/00
A61P 33/02

US Classification:

4241721, 514272

Abstract:

Disclosed are compounds of the formula Ior a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.