Miguel A Jimenez

US Patent:

20200319180, Oct 8, 2020

Filed:

Jun 19, 2020

Appl. No.:

16/906669

Inventors:

- New York NY, US
Nili Ostrov - Brookline MA, US
Miguel Jimenez - Winthrop MA, US
Sonja Billerbeck - Groningen, NL

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

G01N 33/566
C12Q 1/02
G01N 33/74
G01N 33/50
C12Q 1/00
C12Q 1/06
G01N 33/569

Abstract:

The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.

US Patent:

20200164193, May 28, 2020

Filed:

Nov 26, 2019

Appl. No.:

16/696233

Inventors:

- Cambridge MA, US
Jason Siu Wei Li - Cambridge MA, US
Jacob Coffey - Boston MA, US
Christoph Winfried Johannes Steiger - Oberasbach, DE
Miguel Jimenez - Boston MA, US
Robert S. Langer - Newton MA, US
Ester Caffarel Salvador - Cambridge MA, US
Alex Abramson - St. Louis MO, US

International Classification:

A61M 37/00
A01K 11/00

Abstract:

A platform technology has been designed to provide a means for controlled delivery of single or multiple doses of therapeutic, prophylactic, diagnostic or identifying agents to livestock. The delivery system is based on a livestock ear tag that releases therapeutic and/or prophylactic agent when applied to the ear or other desired anatomical target of the animal. The agent to be delivered is encapsulated in or on microneedles and or microparticles and or nanoparticles or combination thereof on a surface thereon of the male or female part of the tag, which is pressed into the skin so that the microneedles penetrate into the epidermis and dermis layers of the skin. The agent is then released into the animal from the microneedles and or microparticles and or nanoparticles or combination thereof at the site of contact into the epidermis and dermis layers of the skin.

US Patent:

20170336407, Nov 23, 2017

Filed:

May 16, 2017

Appl. No.:

15/596837

Inventors:

- New York NY, US
Nili Ostrov - Boston MA, US
Miguel Jimenez - New York NY, US
Sonja Billerbeck - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

G01N 33/566
C12Q 1/02
G01N 33/50
C12Q 1/06
G01N 33/569
C12Q 1/00

Abstract:

The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.