Peter Crooks - Nicholasville KY, US Miguel Rivera - Sarasota FL, US
International Classification:
A61K031/4035 A61K031/4015 A61K031/195 A61K031/165
US Classification:
514/417000, 514/424000, 514/620000, 514/567000
Abstract:
The present invention relates to norketamine and ketamine/norketamine prodrugs, and methods of their use as analgesics. More particularly, the invention relates to norketamine and N-conjugated prodrugs of ketamine and norketamine, and methods of using these agents for the management of chronic pain without requiring administration of narcotics. The invention relates to self-management of pain on an outpatient basis comprising administering via conventional routes, including transdermal, nasal, rectal, oral, transmucosal, intravenous, intramuscular, and other routes, one or more doses of norketamine and/or ketamine/norketamine prodrugs effective to alleviate pain to a subject suffering from pain. Uses of norketamine and ketamine/norketamine prodrugs would also apply, to treating headaches, drug abuse, mood and anxiety disorders, as well as other neuropsychiatric disorders, both motoric and cognitive, such as Alzheimer's disease, Parkinson's syndrome, which are thought to be caused by neurodegeneration.
Ocean County prosecutors say 24-year-old Jesus Roman and 23-year-old Carlos Lagunes, both of Sussex, also face burglary and hindering charges in the death of Lakewood resident Miguel Rivera. Bail was set at $1 million cash for both men, and it wasn't known Tuesday if either one has retained an attor
The Andalusians sacked Juan Ignacio Martinez at the weekend after a 4-1 defeat to Levante left them in the relegation zone with Miguel Rivera set to take temporary charge, just as he did in a 4-1 defeat to Real Madrid earlier in the season after Francisco had been fired.
Date: Apr 06, 2015
Category: Sports
Source: Google
The Hottest Boxing Storylines for the Week of March 22
But his trainer Nacho Beristain, per ESPN Deportes (h/t Miguel Rivera of Boxingscene.com), believes his main man could elect to call it quits due to lingering knee issues that have prevented him from giving 100 percent while training.
Date: Mar 22, 2015
Category: Sports
Source: Google
Cop accused in NJ brutality video didn't tell grand jury about kicks, beating
Two videos show Alexis Aponte and Miguel Rivera repeatedly being kicked and beaten while they were allegedly handcuffed in September 2011. The video was first made public by The Star-Ledger late Sunday night on NJ.com, the newspapers online home.
Date: Jul 02, 2013
Category: U.S.
Source: Google
Hot putter gives Hoffman lead at RBC Heritage going into final round
"We started kind of getting it out of position, which is easy to do on this golf course," said Miguel Rivera, Hoffman's caddie. "Then we just hit our second shots in spots where we had good, easy chips. We didn't maybe chip it as close as we'd like to, but left ourselves a lot of uphill putts. You c
that meant Mr. Mir and Miguel Rivera, partners in Austins Mir Rivera Architects, got to design more than grandstands and ticket booths; their work includes a 250-foot observation tower made of thousands of steel pipes, painted red, as if to mimic the streaks of lights trailing racecars at night. The
Date: Nov 16, 2012
Category: Sports
Source: Google
Julio Cesar Chavez Jr: I Have Never Smoked Marijuana
It also comes amid statements from the President of the WBC Jose Sulaiman that Chavez Jr. also has a severe gambling addiction:"[He makes all of this money] and just gives it [right back] to the casinos, and that is truly terrible," Sulaimantold Miguel Rivera ofBoxingscene.com.