Miguel A Rivera

US Patent:

20040248964, Dec 9, 2004

Filed:

Nov 18, 2003

Appl. No.:

10/714643

Inventors:

Peter Crooks - Nicholasville KY, US
Miguel Rivera - Sarasota FL, US

International Classification:

A61K031/4035
A61K031/4015
A61K031/195
A61K031/165

US Classification:

514/417000, 514/424000, 514/620000, 514/567000

Abstract:

The present invention relates to norketamine and ketamine/norketamine prodrugs, and methods of their use as analgesics. More particularly, the invention relates to norketamine and N-conjugated prodrugs of ketamine and norketamine, and methods of using these agents for the management of chronic pain without requiring administration of narcotics. The invention relates to self-management of pain on an outpatient basis comprising administering via conventional routes, including transdermal, nasal, rectal, oral, transmucosal, intravenous, intramuscular, and other routes, one or more doses of norketamine and/or ketamine/norketamine prodrugs effective to alleviate pain to a subject suffering from pain. Uses of norketamine and ketamine/norketamine prodrugs would also apply, to treating headaches, drug abuse, mood and anxiety disorders, as well as other neuropsychiatric disorders, both motoric and cognitive, such as Alzheimer's disease, Parkinson's syndrome, which are thought to be caused by neurodegeneration.

US Patent:

20130220933, Aug 29, 2013

Filed:

Feb 11, 2013

Appl. No.:

13/764760

Inventors:

William A. Farone - Irvine CA, US
Shane L. Palmer - Coto De Caza CA, US
Miguel Rivera - Orange CA, US
Dwayne C. Chong - San Dimas CA, US

International Classification:

C02F 1/28

US Classification:

210663, 210138, 210194

Abstract:

An apparatus for removing target chemicals from water includes a reaction chamber, a source of an aqueous solution of the target chemicals that can be supplied on demand to the reaction chamber, a timer that times a reaction between the particles and the target chemicals such that a concentration of the target chemicals in the aqueous solution reaches a predetermined low level in a desired time, and elements for removing the aqueous phase from the reactor while keeping the particles entrained inside the reactor using a microfilter configured to be back flushed, adding aqueous solution to the reactor from the source and continuing cycles until the particles are saturated, removing and replacing the particles in a final cycle of a particle charge lifetime, and recovering the target chemicals from the particles such that the particles can be reused.

US Patent:

D4463889, Aug 14, 2001

Filed:

Nov 3, 2000

Appl. No.:

D/132159

Inventors:

Miguel A Rivera - Buena Park CA

International Classification:

0301

US Classification:

D 3208

US Patent:

20150247204, Sep 3, 2015

Filed:

Feb 6, 2015

Appl. No.:

14/616297

Inventors:

- Boston MA, US
- Santa Clara CA, US
Quan Nguyen - San Ramon CA, US
Yunqing MA - San Jose CA, US
David T. Ting - Dover MA, US
Miguel Rivera - Cambridge MA, US

International Classification:

C12Q 1/68

Abstract:

Methods for making a differential diagnosis of hepatic neoplasms, e.g., tumors, and for identifying metastatic tumors of hepatic origin, based on detection of levels of albumin mRNA. The methods can also be used to select treatments or guide treatment decisions.

US Patent:

20150232935, Aug 20, 2015

Filed:

Feb 13, 2015

Appl. No.:

14/622219

Inventors:

- Boston MA, US
- Santa Clara CA, US
Quan Nguyen - San Ramon CA, US
Yunqing MA - San Jose CA, US
David T. Ting - Dover MA, US
Miguel Rivera - Cambridge MA, US
Nicolo Riggi - Boston MA, US

International Classification:

C12Q 1/68
C07K 16/28

Abstract:

Methods for diagnosing and treating IgG4-related disease (IgG4-RD), e.g., based on detecting levels of IgG4 mRNA, preferably using a branched DNA assay.