Milan F Radojicic

US Patent:

20090227851, Sep 10, 2009

Filed:

Aug 16, 2008

Appl. No.:

12/228697

Inventors:

Milan Radojicic - Fremont CA, US

International Classification:

A61B 5/03
A61M 25/00
A61B 8/14
A61B 6/00

US Classification:

600309, 604 43, 600459, 600473, 600476

Abstract:

This invention is a continuous monitor of the spinal cord and brain microenvironment in injury and disease that also allows therapeutic interventions. It utilizes a multiport catheter that contains a transducer at the tip for monitoring spinal physiological parameters and also allows via additional ports for sampling and exchange of spinal fluid, as well as drug delivery to the central nervous system. This invention allows for more precise therapeutic interventions in spinal cord and brain injury and disease. If the pressure monitor is mounted to the patient, the wireless data transmitter may also send a wireless signal to a wireless data receiver for display on a wireless data display. The catheter would allow for wireless transmission of physiological parameters.

US Patent:

20100312084, Dec 9, 2010

Filed:

Aug 16, 2010

Appl. No.:

12/857555

Inventors:

Milan Radojicic - Los Gatos CA, US

International Classification:

A61B 5/00
A61M 5/142

US Classification:

600365, 604151

Abstract:

A system and method for accessing and treating the cerebrospinal fluid with a multilumen catheter configured for placement along a cerebrospinal fluid pathway and a subcutaneous, dual reservoir/pump. The subcutaneous dual reservoir/pump allows simultaneous, bidirectional cerebrospinal fluid access and cerebrospinal fluid exchange. The two chambers prevent mixing of newly treated and discardable cerebrospinal fluid. The subcutaneous dual reservoir/pump can be used inline with other cerebrospinal fluid devices. The catheter may be coupled with a medical probe that sends a wire to a computational device, which can then send wireless data and receive wireless instructions. A method of assessing cerebrospinal fluid infections is provided, whereby monitoring of the cerebrospinal glucose concentrations with a cerebrospinal glucose sensor and analysis of the data by a computational device can notify a patient or medical provider of an impending infection. This assembly can help better diagnose and treat injury and disease.

US Patent:

20120095383, Apr 19, 2012

Filed:

Dec 20, 2011

Appl. No.:

13/332349

Inventors:

Milan Radojicic - Los Gatos CA, US

International Classification:

A61M 1/00

US Classification:

604 8

Abstract:

The present invention relates to a biologically active medical device, which includes a matrix seeded with progenitor cells, and then covered by ciliated tissue. The matrix is capable of enabling cellular migration. The ciliated tissue is ependymal cells that express at least one of tight junctional complexes, zonula adherens, and gap junctions. The progenitor cells include subpendymal progenitor cells. In some cases the progenitor cells include stem cells, and the ciliated tissue includes at least one of Choroid cells, tanacytes, and circumventricular organs. In some embodiments, the medical device is oriented into a tubular structure in order to form a cerebrospinal shunt. Additional cells and structures may be imbedded within the matrix, such as glia, endothelial cells, stem cells, and blood vessels. The medical device may also be incorporated into a bioreactor including a flexible inner tube defining an anthropomorphically shaped lumen.

US Patent:

20120271168, Oct 25, 2012

Filed:

Apr 20, 2012

Appl. No.:

13/452517

Inventors:

Milan Radojicic - Los Gatos CA, US

International Classification:

A61B 5/0205
A61B 8/00

US Classification:

600439, 600483

Abstract:

A computational catheter device including at least one lumen, pressure sensor(s), external sensor(s), a signal modeler, and a signal analyzer is provided. The pressure sensor generates a pressure signal for a dynamic body system, whereas the external sensor determines the fundamental frequency caused by cardiovascular pulsation or external oscillator. The signal modeler uses catheter location and the fundamental frequency to generate a predicted signal. This predicted signal may be compared to the actual pressure signal by the signal analyzer to generate a calibration. This calibration may include any of a measure of perivascular state, a waveform output which causes standing waves within the dynamic body system, a boundary condition for safe operations, and an indication of abnormal physiology for assistance in catheter navigation. The catheter device may also include an actuator which uses the calibration to achieve homeostasis by fluxing fluids and/or guiding catheter movements.

US Patent:

20150342746, Dec 3, 2015

Filed:

Dec 24, 2012

Appl. No.:

13/726403

Inventors:

Milan Radojicic - Los Gatos CA, US

Assignee:

Neurosyntec Corp. - Los Gatos CA

International Classification:

A61F 2/44

Abstract:

Sensor information is received that indicates insertion of an insertion mechanism into a mechanical body. A virtual representation of the spinal region is generated. The insertion mechanism is represented graphically, as part of the virtual representation, as the insertion mechanism is inserted into the mechanical body

US Patent:

20140273218, Sep 18, 2014

Filed:

May 30, 2014

Appl. No.:

14/292767

Inventors:

- Newark DE, US
Milan Radojicic - Los Gatos CA, US

Assignee:

AGATHOS HOLDINGS LLC - Newark DE

International Classification:

A61L 27/22
A61L 31/00
A61L 31/04
A61M 27/00

US Classification:

435375, 604 9

Abstract:

The present invention relates to a biologically active medical device, which includes a matrix seeded with progenitor cells, and then covered by ciliated tissue. The matrix is capable of enabling cellular migration. The ciliated tissue is ependymal cells that express at least one of tight junctional complexes, zonula adherens, and gap junctions. The progenitor cells include subpendymal progenitor cells. In some cases the progenitor cells include stem cells, and the ciliated tissue includes at least one of Choroid cells, tanacytes, and circumventricular organs. In some embodiments, the medical device is oriented into a tubular structure in order to form a cerebrospinal shunt. Additional cells and structures may be imbedded within the matrix, such as glia, endothelial cells, stem cells, and blood vessels. The medical device may also be incorporated into a bioreactor including a flexible inner tube defining an anthropomorphically shaped lumen.