Min Hu

US Patent:

6974805, Dec 13, 2005

Filed:

Aug 1, 2003

Appl. No.:

10/632599

Inventors:

Min Hu - Fremont CA, US

International Classification:

A61K031/726
A61K031/715
A61K031/738

US Classification:

514 54, 536 551, 536 53

Abstract:

The present invention provides stable glycosaminoglycan (GSG) structures and methods of use of such GAG structures. These structures comprise a core of free GAG, a coating of crosslinked GAG surrounding the core, and a layer of a positively charged moiety surrounding the crosslinked GAG layer. These GAG structures provide improved stability, both in in vivo and external use. Furthermore, resurfacing of the structures provides improved cell adhesion and thus improved delivery of the GAG into living cells and tissues.

US Patent:

8269963, Sep 18, 2012

Filed:

Apr 30, 2010

Appl. No.:

12/771779

Inventors:

Fung Suong Ou - Palo Alto CA, US
Min Hu - Sunnyvale CA, US
Wei Wu - Palo Alto CA, US
Zhiyong Li - Redwood City CA, US
R Stanley Williams - Portola Valley CA, US

Assignee:

Hewlett-Packard Development Company, L.P. - Houston TX

International Classification:

G01J 3/44

US Classification:

356301

Abstract:

A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable layer and a plurality of SERS-active nanoparticles disposed at one or more locations on the deformable layer, wherein the one or more locations are configured to be illuminated with light of a pump wavelength to cause Raman excitation light to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles. In addition, a morphology of the deformable layer is configured to be controllably varied to modify an intensity of the Raman scattered light produced from the molecules.

US Patent:

8358408, Jan 22, 2013

Filed:

Apr 30, 2010

Appl. No.:

12/771824

Inventors:

Wei Wu - Palo Alto CA, US
Min Hu - Sunnyvale CA, US
Fung Suong Ou - Palo Alto CA, US
Zhiyong Li - Redwood City CA, US

Assignee:

Hewlett-Packard Development Company, L.P. - Houston TX

International Classification:

G01J 3/44

US Classification:

356301

Abstract:

An apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a reflective layer positioned above the substrate, a plurality of tapered nanowires disposed above the reflective layer, each of the plurality of tapered nanowires having a tapered end directed away from the reflective layer.

US Patent:

8390804, Mar 5, 2013

Filed:

Jan 29, 2010

Appl. No.:

12/697136

Inventors:

Michael J. Stuke - Palo Alto CA, US
Alexandre M. Bratkovski - Mountain View CA, US
Min Hu - Sunnyvale CA, US
Huei Pei Kuo - Cupertino CA, US
Jingjing Li - Palo Alto CA, US
Zhiyong Li - Redwood City CA, US
Fung Suong Ou - Palo Alto CA, US
Shih-Yuan (Sy) Wang - Palo Alto CA, US
Wei Wu - Palo Alto CA, US

Assignee:

Hewlett-Packard Development Company, L.P. - Houston TX

International Classification:

G01J 3/44

US Classification:

356301

Abstract:

A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.

US Patent:

8462333, Jun 11, 2013

Filed:

Oct 15, 2010

Appl. No.:

12/905891

Inventors:

Wei Wu - Palo Alto CA, US
Zhiyong Li - Redwood City CA, US
Shih-Yuan Wang - Palo Alto CA, US
Michael Josef Stuke - Palo Alto CA, US
Lars Helge Thylen - Huddinge, SE
Fung Suong Ou - Palo Alto CA, US
Min Hu - Sunnyvale CA, US

Assignee:

Hewlett-Packard Development Company, L.P. - Houston TX

International Classification:

G01J 3/44

US Classification:

356301

Abstract:

An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.

US Patent:

8472018, Jun 25, 2013

Filed:

Jul 30, 2010

Appl. No.:

12/847982

Inventors:

Michael J. Stuke - Palo Alto CA, US
Michael R. T. Tan - Menlo Park CA, US
Alexandre M. Bratkovski - Mountain View CA, US
Min Hu - Sunnyvale CA, US
Huei Pei Kuo - Cupertino CA, US
Jingjing Li - Palo Alto CA, US
Zhiyong Li - Redwood City CA, US
Fung Suong Ou - Palo Alto CA, US
Shih-Yuan Wang - Palo Alto CA, US
Wei Wu - Palo Alto CA, US

Assignee:

Hewlett-Packard Development Company, L.P. - Houston TX

International Classification:

G01J 3/44

US Classification:

356301

Abstract:

Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.

US Patent:

8558788, Oct 15, 2013

Filed:

Apr 29, 2011

Appl. No.:

13/066994

Inventors:

Sagi Varghese Mathai - Palo Alto CA, US
Min Hu - Sunnyvale CA, US
Huel Pel Kuo - Cupertino CA, US

Assignee:

Hewlett-Packard Development Company, L.P. - Houston TX

International Classification:

G02B 27/20

US Classification:

345156

Abstract:

Embodiments disclosed herein relate to diffusing light of a multi-mode laser. In one embodiment, the multi-mode laser projects a plurality of modes of light and a diffuser reflects the plurality of modes of light to output a single lobe of light.

US Patent:

8603606, Dec 10, 2013

Filed:

Oct 29, 2010

Appl. No.:

12/916239

Inventors:

Michael Josef Stuke - Palo Alto CA, US
Zhiyong Li - Redwood City CA, US
Shih-Yuan Wang - Palo Alto CA, US
Fung Suong Ou - Palo Alto CA, US
Min Hu - Sunnyvale CA, US
Wei Wu - Palo Alto CA, US
Lars Helge Thylen - Huddinge, SE

Assignee:

Hewlett-Packard Development Company, L.P. - Houston TX

International Classification:

B32B 3/00
B05D 7/00

US Classification:

428141, 428172, 427404, 427331, 4273722, 427547

Abstract:

A device for Surface Enhanced Raman Scattering (SERS). The device includes a plurality of nanostructures protruding from a surface of a substrate, a SERS active metal disposed on a portion of said plurality of nanostructures, and a low friction film disposed over the plurality of nanostructures and the SERS active metal. The low friction film is to prevent adhesion between the plurality of nanostructures.