Min Shiu Lee

US Patent:

7653490, Jan 26, 2010

Filed:

Jun 13, 2002

Appl. No.:

10/172485

Inventors:

Daniel S. Sem - San Diego CA, US
Maurizio Pellecchia - San Diego CA, US
Qing Dong - San Diego CA, US
Mark Kelly - San Diego CA, US
Min S. Lee - Carlsbad CA, US

Assignee:

Triad Liquidating Company LLC - Rancho Santa Fe CA

International Classification:

G06F 7/00

US Classification:

702 19, 702 20, 703 11, 703 13, 707102, 530350

Abstract:

The invention provides a method for obtaining a binding compound for a protein family, wherein the members of the protein family bind a common ligand. The method includes the steps of (a) providing a sample containing a protein from the protein family, a first ligand and a second ligand under conditions wherein the first ligand, the second ligand and the protein form a bound complex; (b) detecting magnetization transfer between the first ligand and the second ligand in the bound complex, thereby determining that the two ligands are proximal in the bound complex; and (c) obtaining a candidate binding compound including the first ligand, or a fragment thereof linked to the second ligand, or a homolog thereof, whereby the population contains binding compounds that bind to members of the protein family.

US Patent:

8173370, May 8, 2012

Filed:

Feb 7, 2008

Appl. No.:

12/027954

Inventors:

Paul A. Oeth - San Diego CA, US
Mathias Ehrich - San Diego CA, US
Min S. Lee - San Diego CA, US

Assignee:

Sequenom, Inc. - San Diego CA

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435 612, 435 61, 435 611

Abstract:

The invention in part provides nucleic acid-based assays, which are particularly useful for non-invasive prenatal testing. The invention in part provides compositions and methods for RhD typing, detecting the presence of fetal nucleic in a sample, determining the relative amount of fetal nucleic acid in a sample and determining the sex of a fetus, wherein each of the assays may be performed alone or in combination.

US Patent:

20080096766, Apr 24, 2008

Filed:

Jun 14, 2007

Appl. No.:

11/763211

Inventors:

Min LEE - San Diego CA, US

Assignee:

Sequenom, Inc. - San Diego CA

International Classification:

C40B 20/08

US Classification:

506006000

Abstract:

The invention relates to methods and kits for the amplification, detection and quantification of a nucleic acid from a sample. The methods of the invention may be used in a wide range of applications, including, but not limited to, the detection and quantification of fetal nucleic acid from maternal plasma, the detection and quantification of circulating nucleic acids from neoplasms (malignant or non-malignant), accurate pooling analysis for low frequency alleles, or any other application requiring sensitive quantitative analysis of nucleic acids.

US Patent:

20090317817, Dec 24, 2009

Filed:

Mar 10, 2009

Appl. No.:

12/401493

Inventors:

Paul Andrew Oeth - San Diego CA, US
Payam Mahboubi - San Diego CA, US
Min Seob Lee - San Diego CA, US

Assignee:

Sequenom, Inc. - San Diego CA

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Provided herein are compositions, processes and kits for noninvasive, early determination of fetal sex from, and/or amount of fetal nucleic acid in, an extracellular nucleic acid sample from a pregnant female. Such compositions, processes and kits are useful for detection of low genomic copy numbers of male fetal nucleic acid in a high copy number background of female nucleic acid, thereby determining the sex of a fetus and/or amount of fetal nucleic acid in a sample.

US Patent:

20110294699, Dec 1, 2011

Filed:

Aug 28, 2008

Appl. No.:

12/674403

Inventors:

Min Seob Lee - San Diego CA, US
Yanfeng Yang - Dublin CA, US

Assignee:

SEQUENOM, INC. - San Diego CA

International Classification:

C40B 30/10
C12Q 1/68

US Classification:

506 12, 435 612, 435 611

Abstract:

Provided herein are products and processes for the amplification, detection and sequencing of short-stranded nucleic acid in the presence of a high background of long-stranded genomic material (e.g., host or maternal nucleic acids). The methods rely on the use of inside and outside primers introduced at varying concentrations, as well as universal amplification reactions that preferentially amplify short, low copy number nucleic acid.

US Patent:

57730814, Jun 30, 1998

Filed:

Jul 31, 1997

Appl. No.:

8/903665

Inventors:

Victor A. Williamitis - Dayton OH
Jeanne E. Lambert - Conyers GA
Min Shiu Lee - Sandy UT
Robert A. Taller - Sandy UT

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

B05D 128

US Classification:

427211

Abstract:

An apparatus for applying a coating to an object includes a pair of rotating members each including a porous resilient roll mounted for counter-rotatory movement. The members are mounted so that they contact each other during a segment of the movement and are out of contact with each other at other segments of the movement. The apparatus includes a coating supply system for supplying a coating to the resilient rolls. The rotatory movement of the members includes a coating loading segment where the resilient rolls are in physical contact and have a degree of compression with the coating supply system for loading the coating into the rolls. The sequential movement also includes an intermediate segment where the resilient rolls are out of contact with each other and where an object to be coated is movable into position for movement between the resilient rolls when the rolls are in a coating delivery segment. In the coating delivery segment, the resilient rolls are in physical contact and have a degree of compression with each other and with the object to be coated as the object is moved between the rolls. The coating delivery segment serves to apply the coating to the object.

US Patent:

58636145, Jan 26, 1999

Filed:

May 28, 1997

Appl. No.:

8/864574

Inventors:

Victor A. Williamitis - Dayton OH
Jeanne E. Lambert - Conyers GA
Min Shiu Lee - Sandy UT
Robert A. Taller - Sandy UT

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

B05D 128

US Classification:

427429

Abstract:

An apparatus for applying a coating to an object includes a pair of reciprocating members which each include a porous resilient pad mounted for movement toward and away from each other. The apparatus includes a coating supply system for supplying coating to the resilient pads. The pads have a movement sequence from an initial rest position where the pads are spaced apart from one another to a coating loading position where the pads are in physical contact and have a degree of compression with each other to load the coating onto the pads, then the pads are moved to an intermediate rest position with the pads spaced apart an the object to be coated is moved between the pads. The sequence then includes a coating delivery position where the pads are in physical contact with each other and the object so that the pads have a degree of compression with each other and the object thereby applying the coating to the object.

US Patent:

57439630, Apr 28, 1998

Filed:

Jul 29, 1996

Appl. No.:

8/681750

Inventors:

Victor A. Williamitis - Dayton OH
Jeanne E. Lambert - Conyers GA
Min Shiu Lee - Sandy UT
Robert A. Taller - Sandy UT

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

B05C 100

US Classification:

118680

Abstract:

An apparatus for applying a coating to an object includes a pair of rotating members each including a porous resilient roll mounted for counter-rotatory movement. The members are mounted so that they contact each other during a segment of the movement and are out of contact with each other at other segments of the movement. The apparatus includes a coating supply system for supplying a coating to the resilient rolls. The rotatory movement of the members includes a coating loading segment where the resilient rolls are in physical contact and have a degree of compression with the coating supply system for loading the coating into the rolls. The sequential movement also includes an intermediate segment where the resilient rolls are out of contact with each other and where an object to be coated is movable into position for movement between the resilient rolls when the rolls are in a coating delivery segment. In the coating delivery segment, the resilient rolls are in physical contact and have a degree of compression with each other and with the object to be coated as the object is moved between the rolls. The coating delivery segment serves to apply the coating to the object.