Ming M Li

Address:

539 Owasso Hl Dr, Saint Paul, MN 55113

Phone:

(651)7652684

VIN:

4S4BP86C674308096

Make:

SUBARU

Model:

LEGACY

Year:

2007

US Patent:

8518259, Aug 27, 2013

Filed:

Jan 27, 2011

Appl. No.:

13/015363

Inventors:

Patrick Cloutier - Andover MN, US
Robert Olsen - Plymouth MN, US
Stephen Roller - Minneapolis MN, US
Chris Plott - St. Paul MN, US
Al McLevish - Apple Valley MN, US
Ming Li - Roseville MN, US
Michael Laxen - Minneapolis MN, US
John Knoll - Brooklyn Park MN, US
Gregory Hake - Otsego MN, US

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

B01D 61/30
B01D 61/28
B01D 61/20
B01D 61/18
A61M 1/36

US Classification:

210646, 210175, 210180, 210183, 210184, 210188, 210252, 210256, 210258, 210436, 210472, 210650, 422 44, 422 45, 422 46, 422 47, 422 48, 604 401, 604 501, 604 609, 604 613, 604 614, 604 28

Abstract:

An apparatus for de-aering, oxygenating and controlling a temperature of blood in an extracorporeal blood circuit. The apparatus includes a housing, a manifold body, a heat exchanger, and an oxygenator. A blood inlet tangentially directs blood into a first chamber of the housing. The manifold body is disposed in a second chamber, and includes a core and a plurality of vanes that define channels. The heat exchanger is arranged around the manifold body, and the oxygenator around the heat exchanger. The channels are open to the heat exchanger. An established blood flow path includes rotational flow within the first chamber to separate air from the blood, generally longitudinal flow from the first chamber and along the channels, and generally radial flow through the heat exchanger and the oxygenator. With this construction, gross air removal occurs prior to the blood passing through the heat exchanger and oxygenator.

US Patent:

8545754, Oct 1, 2013

Filed:

Apr 23, 2009

Appl. No.:

12/428674

Inventors:

Walt L. Carpenter - Minneapolis MN, US
Robert W. Olsen - Plymouth MN, US
Michael J. Hobday - Lino Lakes MN, US
Alford L. McLevish - Maple Grove MN, US
Christopher J. Plott - St. Paul MN, US
Roderick E. Briscoe - Rogers MN, US
Patrick J. Cloutier - Andover MN, US
Anil Thapa - Blaine MN, US
Ming Li - Roseville MN, US
Kevin McIntosh - Brooklyn Park MN, US
Ken Merte - Southlake TX, US

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

A61M 1/00
A61M 1/16

US Classification:

422 46, 422 44, 422 45, 422 48, 604 401, 604 609, 604 613, 604 614

Abstract:

Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises: a core that is substantially centrally located in the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the core and between which blood from the core can move radially outward; and an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and between which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.

US Patent:

8579845, Nov 12, 2013

Filed:

Jan 27, 2011

Appl. No.:

13/015398

Inventors:

Patrick Cloutier - Andover MN, US
Robert Olsen - Plymouth MN, US
Stephen Roller - Minneapolis MN, US
Chris Plott - St. Paul MN, US
Al McLevish - Apple Valley MN, US
Ming Li - Roseville MN, US
Michael Laxen - Minneapolis MN, US
John Knoll - Brooklyn Park MN, US
Gregory Hake - Otsego MN, US

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

A61M 1/36
A61M 1/14

US Classification:

604 613, 604 614, 422 46

Abstract:

A capillary tube bundle sub-assembly for use in an extracorporeal heat exchanger includes a continuous capillary tubing wound about a core to define a plurality of capillary layers each including a plurality of capillary segments. The capillary segments each define opposing terminal ends adjacent opposing ends of the core. The capillary segments of each layer are circumferentially aligned relative to an axis of the core, with each successive layer being radially outward of an immediately preceding layer. The capillary segments are non-parallel with the axis, spiraling partially about the axis in extension between the opposing terminal ends. Each capillary segment forms less than one complete revolution (i. e. , winds less than 360). The segments within each layer are substantially parallel with one another; however, an orientation of the segments differs from layer-to-layer such as by pitch or angle.

US Patent:

20100269342, Oct 28, 2010

Filed:

Apr 23, 2009

Appl. No.:

12/428706

Inventors:

Walt L. Carpenter - Minneapolis MN, US
Robert W. Olsen - Plymouth MN, US
Michael J. Hobday - Lino Lakes MN, US
Alford L. McLevish - Maple Grove MN, US
Christopher J. Plott - St. Paul MN, US
Roderick E. Briscoe - Rogers MN, US
Patrick J. Cloutier - Andover MN, US
Anil Thapa - Blaine MN, US
Ming Li - Roseville MN, US

International Classification:

B21D 53/02

US Classification:

2989003

Abstract:

Described is a method of making an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit, the steps comprising: providing a core through which blood can be supplied to the apparatus from a patient; providing a heat exchanger about the core such that blood from the core can move radially outward through the heat exchanger; providing an oxygenator about the heat exchanger such that blood from the heat exchanger can move radially outward through the oxygenator; and placing the core, heat exchanger and oxygenator in a housing that includes an inlet in communication with the core and an outlet that is located radially outward from the inlet in order to define a flowpath for blood through the apparatus.

US Patent:

20100272606, Oct 28, 2010

Filed:

Apr 23, 2009

Appl. No.:

12/428697

Inventors:

Walt L. Carpenter - Minneapolis MN, US
Robert W. Olsen - Plymouth MN, US
Michael J. Hobday - Lino Lakes MN, US
Alford L. McLevish - Maple Grove MN, US
Christopher J. Plott - St. Paul MN, US
Roderick E. Briscoe - Rogers MN, US
Partick J. Cloutier - Andover MN, US
Anil Thapa - Blaine MN, US
Ming Li - Roseville MN, US

International Classification:

A61M 1/36

US Classification:

422 46

Abstract:

Described is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit comprising: an inlet mandrel that is configured such that the blood moves radially outward from the inlet mandrel through the openings in a radial direction; a heat exchanger arranged around the inlet mandrel, wherein blood can move radially outward with the transfer of heat to or from the blood; an oxygenator arranged around the heat exchanger, wherein blood can move from the heat exchanger radially outward with the transfer of oxygen into the blood; and a housing that houses the inlet mandrel, the heat exchanger and the oxygenator, and that comprises a blood inlet in communication with the inlet mandrel in order to allow blood to enter the apparatus from the patient, and a blood outlet in communication with the oxygenator in order for blood to exit the apparatus, wherein the blood outlet is located in the housing radially outward from the inlet.

US Patent:

20100272607, Oct 28, 2010

Filed:

Apr 23, 2009

Appl. No.:

12/428716

Inventors:

Walt L. Carpenter - Minneapolis MN, US
Robert W. Olsen - Plymouth MN, US
Michael J. Hobday - Lino Lakes MN, US
Alford L. McLevish - Maple Grove MN, US
Christopher J. Plott - St. Paul MN, US
Roderick E. Briscoe - Rogers MN, US
Patrick J. Cloutier - Andover MN, US
Anil Thapa - Blaine MN, US
Ming Li - Roseville MN, US
Kevin McIntosh - Brooklyn Park MN, US
Ken Merte - South Lake TX, US

International Classification:

A61M 1/36

US Classification:

422 46

Abstract:

Described is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit, the apparatus having an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus, the apparatus comprising: a core in communication with the inlet such that blood from a patient can be supplied to the core, the core comprising a first element and a second element that interfit to define openings, wherein the elements and the openings together enhance flow of blood from the patient radially outward from the core; a heat exchanger that is arranged about the core and through which blood from the core can move radially outward; and an oxygenator that is arranged about the heat exchanger and through which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.

US Patent:

20140048234, Feb 20, 2014

Filed:

Oct 25, 2013

Appl. No.:

14/063182

Inventors:

Robert Olsen - Plymouth MN, US
Stephen Roller - Minneapolis MN, US
Chris Plott - St. Paul MN, US
Al McLevish - Apple Valley MN, US
Ming Li - Roseville MN, US
Michael Laxen - Minneapolis MN, US
John Knoll - Brooklyn Park MN, US
Gregory Hake - Otsego MN, US

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

F28D 15/04
A61M 1/36

US Classification:

16510426

Abstract:

A capillary tube bundle sub-assembly for use in an extracorporeal heat exchanger includes a continuous capillary tubing wound about a core to define a plurality of capillary layers each including a plurality of capillary segments. The capillary segments each define opposing terminal ends adjacent opposing ends of the core. The capillary segments of each layer are circumferentially aligned relative to an axis of the core, with each successive layer being radially outward of an immediately preceding layer. The capillary segments are non-parallel with the axis, spiraling partially about the axis in extension between the opposing terminal ends. Each capillary segment forms less than one complete revolution (i.e., winds less than 360). The segments within each layer are substantially parallel with one another; however, an orientation of the segments differs from layer-to-layer such as by pitch or angle.

US Patent:

20140275224, Sep 18, 2014

Filed:

Nov 3, 2011

Appl. No.:

13/883267

Inventors:

Reuben S. Harris - Saint Paul MN, US
Daniel A. Harki - Minneapolis MN, US
Michael A. Carpenter - Minneapolis MN, US
Ming Li - Saint Paul MN, US

Assignee:

Regents of the University of Minnesota - St. Paul MN

International Classification:

C07D 417/14
A61K 31/4709
C07D 417/12
C07D 235/28
A61K 31/4184
A61K 31/4439
A61K 31/428
C07D 235/18
C07D 277/66
A61K 31/433
C07D 285/08
A61K 31/713
C07D 277/74

US Classification:

514 44 R, 546167, 5483071, 544135, 5483107, 548179, 548129, 5462687, 435184

Abstract:

Compounds and methods are provided for enhancing or boosting the transfection rate or efficiency of mammalian cells by foreign DNA, such as bacterial plasmid DNA. Compounds, including natural products and inventive synthetic compounds can increase the effectiveness of uptake and incorporation of foreign DNA by mammalian cells, such as human cells, by suppression of DNA cytosine deamination, which is believed to be a mechanism by which these cells eliminate foreign DNA. Inhibition of the cytosine deaminase enzymes by compounds as described herein serves to provide more effective transfection of eukaryotic cells by plasmids including engineered gene sequences. Transfection can be used to study cellular processes, or to cure genetic diseases in human patients. The inventive materials and methods increase the efficiency and effectiveness of such transfection techniques.