Ming Yang Liu

US Patent:

8415385, Apr 9, 2013

Filed:

Jul 12, 2011

Appl. No.:

13/180996

Inventors:

Hao Chen - Columbia MD, US
Ming Liu - Rockville MD, US
Qi Su - Columbia MD, US
Manish Raisinghani - Jamesburg NJ, US

International Classification:

A61K 31/4245
C07D 271/04

US Classification:

514364, 548125

Abstract:

Derivatives of Sydnonimine and its analogues, which bind selectively to dopamine transporter (DAT) proteins are useful for treating and delaying the progression of disorders and illnesses that are alleviated by inhibiting dopamine reuptake.

US Patent:

20010046868, Nov 29, 2001

Filed:

Jan 24, 2001

Appl. No.:

09/768089

Inventors:

Ming Liu - Potomac MD, US
Jay Sengupta - Londoin, GB
Michael Wasse - Bedfordshire, GB

International Classification:

H04Q007/20

US Classification:

455/452000, 455/450000, 455/062000, 455/186100

Abstract:

In a satellite communications network, local pools of available carriers are assigned to each ground earth station GES by a network channel management station NCMS, which stores a pool of unallocated carriers. If the number of unused carriers in a local pool falls below a predetermined level, additional carriers are allocated from a regional pool in the network channel management station NCMS. If the number of carriers in a local pool exceeds a predetermined level, the excess carriers are released to the regional pool so that they can be allocated to local pools in other ground earth stations GES.

US Patent:

20020042423, Apr 11, 2002

Filed:

Apr 29, 1999

Appl. No.:

09/301339

Inventors:

JOHN R. RICHERT - CHEVY CHASE MD, US
MING LIU - FALLS CHURCH VA, US
SHAOMENG WANG - MCLEAN VA, US
NIKLAS KOHLER - BRAUNSCHWEIG, DE
DAXU YIN - BALTIMORE MD, US

International Classification:

A61K031/505
A61K031/47
A61K031/13
A61K031/16

US Classification:

514/259000, 514/260000, 514/307000, 514/579000

Abstract:

A novel method for identifying compounds which bind HLA molecules and which can be used as HLA agonists or antagonists is provided. These compounds are useful especially in the treatment of autoimmune diseases, transplantation, graft-vs-host disease, and more particularly multiple sclerosis.

US Patent:

20040117125, Jun 17, 2004

Filed:

Sep 25, 2003

Appl. No.:

10/669705

Inventors:

Hao Chen - Columbia MD, US
David Manyak - Ellicott City MD, US
Peter Carlson - Chevy Chase MD, US
Fong Wang - Potomac MD, US
Ming Liu - Rockville MD, US

International Classification:

G06F019/00
G01N033/48
G01N033/50
G01N031/00

US Classification:

702/019000, 702/022000

Abstract:

Methods and systems for drug discovery and development are disclosed. Methods and system consistent with the present invention discover drugs. One or more databases comprising chemical and biological interaction data and one or more computer-based data analysis programs may be used to identify compounds that have desired activity at two or more molecular targets that are associated with a disease state for which the drug discovery and development are directed. In addition, one or more databases comprising chemical and biological interaction data and one or more computer-based data analysis programs may be used to identify compounds that (a) have desired activity at one or more molecular targets that are associated with a disease state for which the drug discovery and development are directed and (b) do not have activity or have substantially reduced activity that is undesired at one or more molecular targets that are associated with possible side effects, toxicity, adverse ADME properties, or other properties not intended to be manifested by compounds being developed to treat the disease state associated with the drug discovery.

US Patent:

20060136140, Jun 22, 2006

Filed:

Dec 16, 2005

Appl. No.:

11/303603

Inventors:

Scott Perschke - Glen Rock PA, US
Ming Liu - Rockville MD, US

International Classification:

G06F 19/00

US Classification:

702019000

Abstract:

Materials, methods and a computer system are provided which facilitate the identification and characterization of modulators of potassium ion channels, particularly the HERG channel.

US Patent:

20080319030, Dec 25, 2008

Filed:

Mar 14, 2008

Appl. No.:

12/048334

Inventors:

Hao Chen - Columbia MD, US
Ming Liu - Rockville MD, US
Qi Su - Columbia MD, US
Manish Raisinghani - Jamesburg NJ, US

International Classification:

A61K 31/4245
C07D 271/04
A61P 25/16
A61P 25/18
A61P 25/24

US Classification:

514364, 548125

Abstract:

Derivatives of Sydnonimine and its analogues, which bind selectively to dopamine transporter (DAT) proteins are useful for treating and delaying the progression of disorders and illnesses that are alleviated by inhibiting dopamine reuptake.

US Patent:

20090215839, Aug 27, 2009

Filed:

Apr 24, 2009

Appl. No.:

12/429644

Inventors:

Hao Chen - Columbia MD, US
Ming Liu - Rockville MD, US
Qi Su - Columbia MD, US
Manish Raisinghani - Jamesburg NJ, US

International Classification:

A61K 31/4245

US Classification:

514364

Abstract:

Derivatives of Sydnonimine and its analogues, which bind selectively to dopamine transporter (DAT) proteins are useful for treating and delaying the progression of disorders and illnesses that are alleviated by inhibiting dopamine reuptake.

US Patent:

20100191475, Jul 29, 2010

Filed:

Mar 4, 2010

Appl. No.:

12/717503

Inventors:

Scott Perschke - Glen Rock PA, US
Ming Liu - Rockville MD, US

International Classification:

G06F 19/00
C07D 451/12
C07D 223/28
C07D 307/81
C07D 453/04
C07C 311/08
C07D 405/14
C07D 401/12
C07D 211/14
C07C 217/48
C07D 211/22
C07H 17/08
C07D 403/04
C07D 211/52
C07D 487/04
C07D 211/60
C07C 255/43
C07D 211/58
C07C 217/64
C07C 211/63

US Classification:

702 19, 546130, 540592, 549467, 546134, 564 81, 544370, 546199, 546203, 564317, 546241, 536 72, 540557, 546217, 544282, 546201, 546228, 558426, 546221, 564352, 564289

Abstract:

Materials, methods and a computer system are provided which facilitate the identification and characterization of modulators of potassium ion channels, particularly the HERG channel.