Ming L Tan

US Patent:

20030138973, Jul 24, 2003

Filed:

Dec 23, 2002

Appl. No.:

10/328925

Inventors:

Peter Wagner - Belmont CA, US
Dana Ault-Riche - Hayward CA, US
Steffen Nock - Redwood City CA, US
Christian Itin - Menlo Park CA, US
Ming Tan - Danville CA, US

International Classification:

G01N033/543

US Classification:

436/518000

Abstract:

Methods and devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules immobilized on the surface of the devices of the present invention include proteins, polypeptides, polynucleotides, polysaccharides, phospolipids, and related unnatural polymers of biological relevance. These devices are useful drug development, functional proteomics and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.

US Patent:

20090042744, Feb 12, 2009

Filed:

Jul 10, 2008

Appl. No.:

12/171217

Inventors:

Peter Wagner - Redwood City CA, US
Dana Ault-Riche - Los Gatos CA, US
Steffen Nock - Redwood City CA, US
Christian Itin - Menlo Park CA, US
Ming Tan - Danville CA, US

Assignee:

Zyomyx, Inc. - Hayward CA

International Classification:

C40B 60/12

US Classification:

506 39

Abstract:

Methods and devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules immobilized on the surface of the devices of the present invention include proteins, polypeptides, polynucleotides, polysaccharides, phospholipids, and related unnatural polymers of biological relevance. These devices are useful drug development, functional proteomics and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.

US Patent:

20200316593, Oct 8, 2020

Filed:

Dec 5, 2019

Appl. No.:

16/705047

Inventors:

- Menlo Park CA, US
Ming X. Tan - San Bruno CA, US
Arturo M. Escajeda - Oakland CA, US

International Classification:

B01L 3/00
B01L 9/00
G01N 21/64

Abstract:

Lateral loading methods of use in high-throughput methods for screening large populations of variant proteins are provided. The methods utilize a flow cell encompassing large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules.

US Patent:

20160033412, Feb 4, 2016

Filed:

Jul 29, 2015

Appl. No.:

14/813015

Inventors:

Ming TAN - Danville CA, US
Leyla SABET - Los Angeles CA, US
Ashutosh SHASTRY - Santa Clara CA, US
Christopher E. TODD - Campbell CA, US
Reuven DUER - Thousand Oaks CA, US

International Classification:

G01N 21/64
G01N 21/77

Abstract:

Optical readers and alignment tools for detecting the level of an analyte. Described herein are small, disposable partially-encapsulated sensing chips for detecting an analyte level from a fluid sample (e.g., a blood sample) having an edge of the integrated sensing chip exposed to directly expose a plurality of excitation and a collection waveguides, as well as optical readers and methods of operating them. A fluid sample maybe applied to a sensing surface of the sensing chip in the housing so that an analyte level can be optically detected. Also described are methods of sensing an analyte using these devices and systems including an optical detector.