Ming Hai Tan

US Patent:

20200316593, Oct 8, 2020

Filed:

Dec 5, 2019

Appl. No.:

16/705047

Inventors:

- Menlo Park CA, US
Ming X. Tan - San Bruno CA, US
Arturo M. Escajeda - Oakland CA, US

International Classification:

B01L 3/00
B01L 9/00
G01N 21/64

Abstract:

Lateral loading methods of use in high-throughput methods for screening large populations of variant proteins are provided. The methods utilize a flow cell encompassing large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules.

US Patent:

20160033412, Feb 4, 2016

Filed:

Jul 29, 2015

Appl. No.:

14/813015

Inventors:

Ming TAN - Danville CA, US
Leyla SABET - Los Angeles CA, US
Ashutosh SHASTRY - Santa Clara CA, US
Christopher E. TODD - Campbell CA, US
Reuven DUER - Thousand Oaks CA, US

International Classification:

G01N 21/64
G01N 21/77

Abstract:

Optical readers and alignment tools for detecting the level of an analyte. Described herein are small, disposable partially-encapsulated sensing chips for detecting an analyte level from a fluid sample (e.g., a blood sample) having an edge of the integrated sensing chip exposed to directly expose a plurality of excitation and a collection waveguides, as well as optical readers and methods of operating them. A fluid sample maybe applied to a sensing surface of the sensing chip in the housing so that an analyte level can be optically detected. Also described are methods of sensing an analyte using these devices and systems including an optical detector.