Ming Jey Yang

US Patent:

7208753, Apr 24, 2007

Filed:

Feb 24, 2006

Appl. No.:

11/307830

Inventors:

Ming Yang - Silver Spring MD, US
Chia-Hung Yang - Silver Spring MD, US
Yuli Lyanda-Geller - West Lafayette IN, US

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

H01L 29/06

US Classification:

257 14, 257 24, 257E29316, 439962, 439E49003

Abstract:

A transistor having a bottom dielectric layer, a first layer, a second layer, a top dielectric layer, and a gate electrode. The first layer and the second layer form a composite quantum well between the bottom dielectric layer and the top dielectric layer. The first layer, the second layer, and the top dielectric layer are configured to form a hole wire in the first layer. The gate electrode is over a portion of the hole wire and divides the top dielectric layer into a source contact and a drain contact.

US Patent:

20130236556, Sep 12, 2013

Filed:

Mar 29, 2013

Appl. No.:

13/853406

Inventors:

Ming Yang - Towson MD, US
Ying-Ying Wang - Baltimore MD, US
Olcay Mert - Ankara, TR
Laura Ensign - Towson MD, US
Justin Hanes - Baltimore MD, US
Jie Fu - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 9/50
A61K 31/704
A61K 31/337

US Classification:

424497, 514449, 514 34

Abstract:

The present invention generally relates to reducing the mucoadhesive properties of a particle. In some embodiments, the particle is coated with and/or associated with a (poly(ethylene glycol))-(poly(propylene oxide))-(poly(ethylene glycol)) triblock copolymer. Methods for preparing inventive particles using a poly(ethylene glycol)-vitamin E conjugate as a surfactant are also provided. In some embodiments, methods are provided comprising administering to a subject a composition of particles of the present invention. Such particles with reduced mucoadhesive properties are useful in delivering agents to mucosal tissues such as oral, ophthalmic, gastrointestinal, nasal, respiratory, and genital mucosal tissues.

US Patent:

20210279817, Sep 9, 2021

Filed:

Feb 8, 2021

Appl. No.:

17/170414

Inventors:

- Menlo Park CA, US
Liu Liu - Marina Del Rey CA, US
Lubomir Dimitrov Bourdev - Mountain View CA, US
Robert D. Fergus - New York NY, US
Ming Yang - Orlando FL, US

International Classification:

G06Q 50/00
G06N 20/00

Abstract:

Systems, methods, and non-transitory computer-readable media can receive a compressed convolutional neural network (CNN). A media content item to be processed can be acquired. The compressed CNN to can be utilized to apply a media processing technique to the media content item to produce information about the media content item. It can be determined, based on at least some of the information about the media content item, whether to transmit at least a portion of the media content item to one or more remote servers for additional media processing.

US Patent:

20200078304, Mar 12, 2020

Filed:

Jul 12, 2019

Appl. No.:

16/510355

Inventors:

- Baltimore MD, US
Ming Yang - Towson MD, US
Ying-Ying Wang - Baltimore MD, US
Olcay Mert - Ankara, TR
Laura Ensign - Towson MD, US
Justin Hanes - Baltimore MD, US
Jie Fu - Baltimore MD, US

International Classification:

A61K 9/16
A61K 49/00
A61K 31/355
A61K 9/00
A61K 45/06
A61K 9/51
A61K 47/60
A61K 47/69

Abstract:

The present invention generally relates to reducing the mucoadhesive properties of a particle. In some embodiments, the particle is coated with and/or associated with a (poly(ethylene glycol))-(poly(propylene oxide))-(poly(ethylene glycol)) triblock copolymer. Methods for preparing inventive particles using a poly(ethylene glycol)-vitamin E conjugate as a surfactant are also provided. In some embodiments, methods are provided comprising administering to a subject a composition of particles of the present invention. Such particles with reduced mucoadhesive properties are useful in delivering agents to mucosal tissues such as oral, ophthalmic, gastrointestinal, nasal, respiratory, and genital mucosal tissues.

US Patent:

20200000734, Jan 2, 2020

Filed:

Sep 10, 2019

Appl. No.:

16/566721

Inventors:

- Redwood City CA, US
Joshua Kays - Baltimore MD, US
Ming Yang - Lutherville-Timonium MD, US
Jeffrey L. Cleland - San Carlos CA, US

International Classification:

A61K 9/50
A61K 9/00
A61K 31/404
A61K 47/10

Abstract:

The present invention is a surface treated drug-loaded solid (e.g., non-porous) microparticle that aggregates in vivo to form a consolidated larger particle for medical therapy. In one embodiment, the particles are used for ocular therapy. Processes for producing the surface treated microparticle and injectable formulations which include the surface treated microparticle are also provided. When used in the eye, long-term consistent intraocular delivery can be achieved without disrupting vision and minimizing undesirable inflammatory responses.

US Patent:

20200000735, Jan 2, 2020

Filed:

Sep 10, 2019

Appl. No.:

16/566724

Inventors:

- Redwood City CA, US
Joshua Kays - Baltimore MD, US
Ming Yang - Lutherville-Timonium MD, US
Jeffrey L. Cleland - San Carlos CA, US

International Classification:

A61K 9/50
A61K 9/00
A61K 31/404
A61K 47/10

Abstract:

The present invention is a surface treated drug-loaded solid (e.g., non-porous) microparticle that aggregates in vivo to form a consolidated larger particle for medical therapy. In one embodiment, the particles are used for ocular therapy. Processes for producing the surface treated microparticle and injectable formulations which include the surface treated microparticle are also provided. When used in the eye, long-term consistent intraocular delivery can be achieved without disrupting vision and minimizing undesirable inflammatory responses.

US Patent:

20190275001, Sep 12, 2019

Filed:

Mar 18, 2019

Appl. No.:

16/357195

Inventors:

- Baltimore MD, US
Justin Hanes - Baltimore MD, US
Joshua Kays - Allston MA, US
Yun Yu - Nottingham MD, US
Ming Yang - Towson MD, US
Jeffrey Cleland - Baltimore MD, US
Walter Stark - Longboat Key FL, US
Qingguo Xu - Baltimore MD, US
Jin Yang - Shanghai, CN

International Classification:

A61K 31/404
A61K 31/506
A61K 9/51
A61K 9/00
A61K 9/19
A61K 9/16

Abstract:

Methods for increasing the encapsulation or incorporation of Sunitinib into polymeric matrices have been developed. The resulting formulations provide for more sustained controlled release of sunitinib or its analog or a pharmaceutically acceptable salt thereof. Increased loading is achieved using an alkaline solvent system. The pharmaceutical compositions can be administered to treat or prevent a disease or disorder in or on the eye of a patient associated with vascularization, such as corneal neovascularization and acute macular degeneration. Upon administration, the sunitinib or its analog or salt is released over an extended period of time at concentrations which are high enough to produce therapeutic benefit, but low enough to avoid unacceptable levels of cytotoxicity.

US Patent:

20170281541, Oct 5, 2017

Filed:

Sep 1, 2015

Appl. No.:

15/509061

Inventors:

- Baltimore MD, US
Ming Yang - Towson MD, US
Michael T. McMahon - Columbia MD, US
Justin Hanes - Baltimore MD, US

International Classification:

A61K 9/127
A61K 31/515
A61K 9/00

Abstract:

Liposome-based mucus-penetrating particles (MPP) capable of loading hydrophilic agents including therapeutic, prophylactic and diagnostic agents such as the diaCEST MRI contrast agent barbituric acid (BA) were evaluated to determine how to optimize delivery. Polyethylene glycol (PEG)-coated liposomes containing ≧7 mol % PEG diffused only approximately 10-fold slower in human cervicovaginal mucus (CVM) compared to their theoretical speeds in water. 7 mol %-PEG liposomes provided improved vaginal distribution compared to 0 and 3 mol %-PEG liposomes.