Ming F Zhang

US Patent:

6960658, Nov 1, 2005

Filed:

Jul 17, 2000

Appl. No.:

09/617174

Inventors:

Arthur Pardee - Brookline MA, US
Ming Zhang - Pearland TX, US

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

C07H021/04

US Classification:

536 234, 4353201, 435325

Abstract:

Isolated nucleic acid molecules that include transcriptional regulatory sequences of the maspin gene are described. These nucleic acid molecules are useful for identifying compounds and proteins that alter expression of maspin in mammary cells and other cell types.

US Patent:

8275092, Sep 25, 2012

Filed:

Jun 3, 2010

Appl. No.:

12/793210

Inventors:

Ming Zhang - Wayland MA, US
Omar Al-Kofahi - Woburn MA, US
Wamiq Ahmed - Woburn MA, US

Assignee:

American Science and Engineering, Inc. - Billerica MA

International Classification:

G01N 23/04

US Classification:

378 57, 378 62

Abstract:

Methods for a tangible image of an inspected object. An object is illuminated with at least two sources of penetrating radiation that generate respective pencil beams and define respective viewing points and view planes. Post-interaction penetrating radiation due to the respective sources is used to generate signals based on respective views of the inspected object, and thus derive information with respect to a dimension transverse to the first view plane based on the second signal. A tangible image of the inspected object is then displayed depicting information with respect at least to the first view plane and the transverse dimension.

US Patent:

8442186, May 14, 2013

Filed:

Feb 8, 2012

Appl. No.:

13/368610

Inventors:

Peter Rothschild - Newton MA, US
Ming Zhang - Wayland MA, US

Assignee:

American Science and Engineering, Inc. - Billerica MA

International Classification:

G01N 23/201

US Classification:

378 86, 378 57, 378 87

Abstract:

A system and methods for characterizing regions within, or on, an inspected object, wherein a lower-Z scattering material and a higher-Z material may both lie along a common line of sight. The inspected object is scanned with penetrating radiation characterized by an energy distribution, and penetrating radiation scattered by the inspected object is detected in a manner that generates two detector signals that distinguish between materials of higher and lower effective atomic number under distinct sets of conditions with respect to the energy distribution of the penetrating radiation. An image is generated, based on a function of the two detector signals, as is a differential image, so as to allow distinction of higher-Z and lower-Z materials.

US Patent:

20080101467, May 1, 2008

Filed:

Oct 27, 2006

Appl. No.:

11/588263

Inventors:

Samuel J. MacMullan - Carlisle MA, US
Tandhoni S. Rao - Ashland MA, US
Jeff Winston - Sudbury MA, US
Jianhan Liu - Acton MA, US
Ming Zhang - Southborough MA, US

Assignee:

Radiospire Networks, Inc. - Concord MA

International Classification:

H04N 7/12

US Classification:

37524012, 37524026

Abstract:

The present invention is directed to methods and systems for enabling secure and efficient wireless transmission of HDCP-encrypted high definition (HD) signals. In one aspect, the present invention provides methods and systems for reducing the data rate required to convey HD content to enable direct wireless transmission of HD content. In another aspect, the present invention provides methods and systems for reducing the data rate required to convey HD content that are compatible with HDCP encryption of content. In a further aspect, the present invention provides methods and systems for reducing the data rate required to convey HD content while maintaining a high quality of content.

US Patent:

20220202356, Jun 30, 2022

Filed:

May 7, 2020

Appl. No.:

17/609226

Inventors:

- Boston MA, US
Lori Lyn Price - Winchester MA, US
Michael Lavalley - Arlington MA, US
Ming Zhang - Westford MA, US

International Classification:

A61B 5/00
A61B 5/107
G06T 7/00

Abstract:

Determining a composite score includes deriving, based on an image set that includes at least one three-dimensional image of the synovial joint, first and second information. The first information indicates cumulative damage to the synovial joint. The second information indicates either one or both joint pain and loss of function of the synovial joint. The resulting composite score provides an objective measure of joint damage or an extent of joint disease.

US Patent:

20210063401, Mar 4, 2021

Filed:

Nov 20, 2018

Appl. No.:

16/765343

Inventors:

- Baltimore MD, US
Kenneth W. Kinzler - Baltimore MD, US
Qing Wang - Owings Mills MD, US
Nickolas Papadopoulos - Towson MD, US
Ming Zhang - Owings Mills MD, US

International Classification:

G01N 33/574

Abstract:

This document provides methods and materials for identifying biomarkers (e.g., peptide biomarkers) that can be used to identify a mammal as having a disease (e.g., cancer). This document also provides methods and materials for identifying and/or treating cancer. For example, this document provides methods and materials for using one or more peptide fragments derived from a peptidyl-prolyl cis-trans isomerase A (PPIA) polypeptide to identify a mammal as having cancer (e.g., ovarian cancer).

US Patent:

20180291369, Oct 11, 2018

Filed:

Feb 28, 2018

Appl. No.:

15/908190

Inventors:

- Towson MD, US
Ming ZHANG - Owings Mills MD, US

Assignee:

MyOmicsDx, Inc - Towson MD

International Classification:

C12N 15/10

Abstract:

A method and kit for constructing a barcoded single-stranded DNA library are disclosed. The method includes preparing single-stranded DNA molecules each having a dephosphorylated 5′ end, ligating a first adaptor to a 3′ end of each single-stranded DNA molecule, and synthesizing a complementary strand of each single-stranded DNA molecule ligated to the first strand of the first adaptor. The kit includes the first adaptor having a first strand, which includes, from a 5′ end to a 3′ end, a phosphate group, a barcode sequence, and a first primer recognition sequence. The kit also includes a DNA ligase for a ligation between the 5′ end of the first strand of the first adaptor to each single-stranded DNA molecule, and a first primer for the synthesis of the complementary strand. The method allows for analysis of rare mutations and from nucleic acid samples of low quality and quantity.

US Patent:

20180291436, Oct 11, 2018

Filed:

Mar 4, 2018

Appl. No.:

15/911161

Inventors:

- Towson MD, US
Ming ZHANG - Owings Mills MD, US

Assignee:

MyOmicsDx, Inc - Towson MD

International Classification:

C12Q 1/6834
B01J 19/00
B01L 3/00
B01L 7/00

Abstract:

A kit and a method for enriching target nucleic acid sequences from a biological sample are disclosed. The method includes preparing, and contacting with the biological sample, a first RNA probe set and a second RNA probe set respectively targeting both of the two antiparallel strands of a duplex segment in each target nucleic acid sequence. Each RNA probe in the first RNA probe set and the second RNA probe set can be generated by chemical synthesis or by in vitro or in vivo transcription, and can be biotin-labelled to thereby allow capturing of the target nucleic acid sequences by magnetic beads labelled with streptavidin, or can be engineered to a microfluidic channel to facilitate the capturing. The method can be applied to capture double-stranded nucleic acid sequences or single-stranded nucleic acid sequences having duplex segments, and the nucleic acid sequences can include DNAs, RNAs, or DNA-RNA hybrid molecules.