Minha S Park

US Patent:

20120020980, Jan 26, 2012

Filed:

Jun 16, 2011

Appl. No.:

13/162497

Inventors:

LAWRENCE M. KAUVAR - SAN FRANCISCO CA, US
STOTE ELLSWORTH - PALO ALTO CA, US
WILLIAM USINGER - LAFAYETTE CA, US
KRISTA MAUREEN MCCUTCHEON - BURLINGAME CA, US
YING-PING JIANG - LAFAYETTE CA, US
FEN ZHANG - SAN FRANCISCO CA, US
BO CHEN - DALY CITY CA, US
GIZETTE SPERINDE - SAN FRANCISCO CA, US
MINHA PARK - BRISBANE CA, US
ORIT FOORD - FOSTER CITY CA, US

Assignee:

TRELLIS BIOSCIENCE, INC. - SOUTH SAN FRANCISCO CA

International Classification:

A61K 39/42
C12N 5/10
A61P 31/20
C12P 21/08
C07K 16/08
C12N 15/13
C12N 1/00

US Classification:

4241421, 536 2353, 435339, 435243, 435419, 435 696, 53038815, 5303873

Abstract:

Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

US Patent:

20120020971, Jan 26, 2012

Filed:

Jun 17, 2011

Appl. No.:

13/163489

Inventors:

Lawrence M. KAUVAR - San Francisco CA, US
Stote Ellsworth - Palo Alto CA, US
William Usinger - Lafayette CA, US
Krista M. McCutcheon - Burlingame CA, US
Minha Park - Brisbane CA, US
Bo Chen - Daly City CA, US
Ying-Ping Jiang - Lafayette CA, US

Assignee:

Trellis Bioscience, Inc. - South San Francisco CA

International Classification:

A61K 39/42
A61P 31/00
C12N 5/10
C12N 15/85
C12P 21/08
C07K 16/10
A61P 31/16

US Classification:

4241361, 5303883, 5303873, 53038815, 4241471, 4353201, 435 696, 435366

Abstract:

Monoclonal antibodies and fragments thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.

US Patent:

20200400669, Dec 24, 2020

Filed:

Jun 4, 2020

Appl. No.:

16/892642

Inventors:

- Emeryville CA, US
Mark P. White - Orinda CA, US
Xiaohua Wang - Pomona NY, US
Minha Park - Brisbane CA, US
Guido K. Stadler - San Francisco CA, US
Xiao Guan Radstrom - San Rafael CA, US
Jason M. McEwen - El Cerrito CA, US
Gang F. Wang - Mountain View CA, US
George L. Fox - Albany CA, US
Peggy A. Radel - Berkeley CA, US

Assignee:

Berkeley Lights, Inc. - Emeryville CA

International Classification:

G01N 33/574
C07K 16/00
G01N 33/569
C07K 16/28
G01N 33/50
C07K 16/30
B01L 3/00
C12Q 1/6886
G01N 33/543

Abstract:

A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

US Patent:

20170276679, Sep 28, 2017

Filed:

Jan 13, 2017

Appl. No.:

15/406289

Inventors:

- Emeryville CA, US
Mark P. White - Orinda CA, US
Xiaohua Wang - Albany CA, US
Minha Park - Brisbane CA, US
Guido K. Stadler - San Francisco CA, US
Xiao Guan - San Rafael CA, US
Jason M. McEwen - El Cerrito CA, US
Gang Wang - Mountain View CA, US
George L. Fox - Albany CA, US
Peggy A. Radel - Berkeley CA, US

International Classification:

G01N 33/574
C12Q 1/68
G01N 33/543
B01L 3/00

Abstract:

A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

US Patent:

20170204165, Jul 20, 2017

Filed:

Mar 20, 2017

Appl. No.:

15/464165

Inventors:

- Menlo Park CA, US
Stote ELLSWORTH - Palo Alto CA, US
William USINGER - Lafayette CA, US
Krista Maureen MCCUTCHEON - Burlingame CA, US
Ying-Ping JIANG - Lafayette CA, US
Fen ZHANG - San Francisco CA, US
Bo CHEN - Daly City CA, US
Gizette SPERINDE - El Granada CA, US
Minha PARK - Brisbane CA, US
Orit FOORD - Foster City CA, US

Assignee:

Trellis Bioscience, LLC - Menlo Park CA

International Classification:

C07K 16/08

Abstract:

Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

US Patent:

20150252099, Sep 10, 2015

Filed:

Apr 27, 2015

Appl. No.:

14/697459

Inventors:

- MENLO PARK CA, US
Stote ELLSWORTH - Palo Alto CA, US
William USINGER - Lafayette CA, US
Krista Maureen MCCUTCHEON - Burlingame CA, US
Ying-Ping JIANG - Lafayette CA, US
Fen ZHANG - San Francisco CA, US
Bo CHEN - Daly City CA, US
Gizette SPERINDE - El Granada CA, US
Minha PARK - Brisbane CA, US
Orit FOORD - Foster City CA, US

International Classification:

C07K 16/08
A61K 39/245
C07K 16/46

Abstract:

Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

US Patent:

20140322210, Oct 30, 2014

Filed:

Dec 5, 2012

Appl. No.:

14/363297

Inventors:

- South San Francisco CA, US
Stote Ellsworth - Palo Alto CA, US
William Usinger - Lafayette CA, US
Krista Maureen McCutcheon - Burlingame CA, US
Minha Park - Brisbane CA, US

International Classification:

C07K 16/10

US Classification:

4241331, 53038815, 5303873, 4241421, 4353201, 435 696, 435339, 435328

Abstract:

Specific monoclonal antibodies and fragments including bispecific antibodies thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.