Mirna Jarosz from Stanford, CA, age 43

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Nucleotide Analogs
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US Patent:

8071755, Dec 6, 2011
Filed:

Apr 4, 2008
Appl. No.:

12/098196
Inventors:

J. William Efcavitch - Can Carlos CA, US
Suhaib Siddiqi - Burlington MA, US
Philip R. Buzby - Brockton MA, US
Judith Mitchell - Brighton MA, US
Subramanian Marappan - Acton MA, US
Xiaopeng Bai - Watertown MA, US
Atanu Roy - Woburn MA, US
Mirna Jarosz - Arlington MA, US
Jayson Bowers - Cambridge MA, US
Assignee:

Helicos Biosciences Corporation - Cambridge MA
International Classification:

C07H 21/00
US Classification:

536 253, 536 185, 536 2531, 536 243, 536 2431, 536 2433
Abstract:

The invention provides for nucleotide analogs and methods of using the same, e. g. , for sequencing nucleic acids.

Methods And Devices For Nucleic Acid Sequence Determination
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US Patent:

8367377, Feb 5, 2013
Filed:

Nov 16, 2009
Appl. No.:

12/618991
Inventors:

Timothy Harris - Ocean County NJ, US
Philip Richard Buzby - Brockton MA, US
Mirna Jarosz - Boston MA, US
James Joseph Dimeo - Needham MA, US
Jaime Gill - Marshfield Hills MA, US
Assignee:

Helicos Biosciences Corporation - Cambridge MA
International Classification:

C12P 19/34
C12Q 1/68
US Classification:

435 911, 435 61
Abstract:

Methods of the invention comprise methods and devices for nucleic acid sequence determination. Generally, the invention relates to preparing a substrate for sequencing a target nucleic acid.

Methods And Devices For Nucleic Acid Sequence Determination
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US Patent:

20060019276, Jan 26, 2006
Filed:

May 25, 2005
Appl. No.:

11/137928
Inventors:

Timothy Harris - Ocean County NJ, US
Philip Buzby - Brockton MA, US
Mirna Jarosz - Boston MA, US
James DiMeo - Needham MA, US
Jaime Gill - Marshfield Hills MA, US
International Classification:

C12Q 1/68
B05D 3/00
US Classification:

435006000, 427002110
Abstract:

Methods of the invention comprise methods and devices for nucleic acid sequence determination. Generally, the invention relates to preparing a substrate for sequencing a target nucleic acid.

Optical Train And Method For Tirf Single Molecule Detection And Analysis
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US Patent:

20070070349, Mar 29, 2007
Filed:

Sep 23, 2005
Appl. No.:

11/234420
Inventors:

Timothy Harris - Toms River NJ, US
Philip Buzby - Brockton MA, US
Mirna Jarosz - Boston MA, US
Jaime Gill - Marshfield Hills MA, US
Howard Weiss - Newton MA, US
Stanley Lapidus - Bedford NH, US
Assignee:

Helicos BioSciences Corporation - Cambridge MA
International Classification:

G01N 21/64
US Classification:

356417000, 250458100
Abstract:

In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.

Optical Train And Method For Tirf Single Molecule Detection And Analysis
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US Patent:

20080087826, Apr 17, 2008
Filed:

Oct 30, 2007
Appl. No.:

11/928715
Inventors:

Timothy Harris - Toms River NJ, US
Philip Buzby - Brockton MA, US
Mirna Jarosz - Boston MA, US
Jaime Gill - Marshfield Hills MA, US
Howard Weiss - Newton MA, US
Stanley Lapidus - Bedford NH, US
Assignee:

Helicos BioSciences Corporation - Cambridge MA
International Classification:

G01J 5/02
G01T 1/16
US Classification:

250353000, 250363010
Abstract:

In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.

Optical Train And Method For Tirf Single Molecule Detection And Analysis
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US Patent:

20080088823, Apr 17, 2008
Filed:

Aug 31, 2007
Appl. No.:

11/849088
Inventors:

Timothy Harris - Toms River NJ, US
Philip Buzby - Brockton MA, US
Mirna Jarosz - Boston MA, US
Jaime Gill - Marshfield Hills MA, US
Howard Weiss - Newton MA, US
Stanley Lapidus - Bedford NH, US
Assignee:

HELICOS BIOSCIENCES CORPORATION - Cambridge MA
International Classification:

G01J 3/00
G01N 21/00
G01N 21/55
US Classification:

356051000, 356073000, 356445000
Abstract:

In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.

Optical Train And Method For Tirf Single Molecule Detection And Analysis
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US Patent:

20080246949, Oct 9, 2008
Filed:

Oct 30, 2007
Appl. No.:

11/928727
Inventors:

Timothy D. Harris - Toms River MA, US
Philip R. Buzby - Brockton MA, US
Mirna Jarosz - Boston MA, US
Jaime Gill - Marshfield MA, US
Howard Weiss - Newton MA, US
Stanley N. Lapidus - Bedford NH, US
Assignee:

Helicos BioSciences Corporation - Cambridge MA
International Classification:

G01J 3/00
G01N 21/00
G01J 3/30
US Classification:

356 51, 356 73, 356318
Abstract:

In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.

Methods For Reducing Contaminants In Nucleic Acid Sequencing By Synthesis
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US Patent:

20090226900, Sep 10, 2009
Filed:

Mar 5, 2008
Appl. No.:

12/043056
Inventors:

Hazen Babcock - Cambridge MA, US
Mirna Jarosz - Cambridge MA, US
Jennifer Colonell - Cambridge MA, US
Parris Wellman - Reading MA, US
Geoff Lowman - Cambridge MA, US
Jayson Bowers - Cambridge MA, US
John Kepler - Cambridge MA, US
Assignee:

HELICOS BIOSCIENCES CORPORATION - Cambridge MA
International Classification:

C12Q 1/68
US Classification:

435 6
Abstract:

The disclosure provides methods that improve fidelity of the sequencing-by-synthesis reactions, including methods that reduce impurities and contamination in various reagents, reaction mixtures, and other components of the sequencing systems.