Mohamed M Ibrahim

US Patent:

20170262537, Sep 14, 2017

Filed:

Mar 14, 2016

Appl. No.:

15/069618

Inventors:

- Seattle WA, US
Mohamed Mostafa Ibrahim Elshenawy - Bellevue WA, US
Joseph Bradford Saunders - Seattle WA, US
Benjamin Schwartz - Seattle WA, US

International Classification:

G06F 17/30
G10L 21/055

Abstract:

Disclosed are various embodiments for initiating playback of audio scripts that correspond to content such as books or songs. Verbal content can be captured via a microphone. The text of the verbal content can be assessed to determine whether an audio script specifies a sound effect that should be played at particular cue words within the content. The verbal content is assessed to determine whether a user reading aloud or singing a song has reached a cue word. When a cue word is reached, the sound effect can be played.

US Patent:

20110288076, Nov 24, 2011

Filed:

Oct 16, 2009

Appl. No.:

13/124604

Inventors:

Mohamed Abdulkader Ibrahim - Mountain View CA, US
Joon Won Jeong - Belmont CA, US
Henry William Beecroft Johnson - San Bruno CA, US
Patrick Kearney - San Francisco CA, US
James W. Leahy - San Leandro CA, US
Gary L. Lewis - San Francisco CA, US
Robin Tammie Noguchi - San Bruno CA, US
John M. Nuss - Danville CA, US

Assignee:

EXELIXIS, INC. - South San Francisco CA

International Classification:

A61K 31/4196
C07D 403/06
C07C 237/22
C07D 307/54
C07D 207/452
C07D 213/56
C07D 403/04
C07D 417/06
C07D 223/04
A61K 31/417
A61K 31/4192
A61K 31/167
A61K 31/341
A61K 31/4015
A61K 31/455
A61K 31/506
A61K 31/541
A61K 31/55
A61P 35/00
A61P 35/02
C07D 277/30

US Classification:

51421712, 548204, 548255, 5482676, 5482656, 564158, 549488, 548546, 546316, 546298, 544295, 544 585, 540610, 514400, 514422, 514383, 514616, 514471, 514425, 514355, 514350, 51425214, 5142278

Abstract:

This disclosure relates to sphingosine-1-phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor antagonists. In particularly, this disclosure relates to sphingosine-1-phosphate 1 (S1P1) receptor antagonists, compositions comprising the S1P1 receptor antagonist and methods for using the S1P1 receptor antagonist, such as in the treatment of cancer, and processes for making the S1P1 receptor antagonists.

US Patent:

20090298830, Dec 3, 2009

Filed:

Jan 30, 2007

Appl. No.:

11/992224

Inventors:

Grace Mann - San Mateo CA, US
Naing Aay - San Mateo CA, US
Arlyn Arcalas - South San Francisco CA, US
S. David Brown - San Carlos CA, US
Wai Ki Vicky Chan - San Francisco CA, US
Jeff Chen - San Francisco CA, US
Hongwang Du - Millbrae CA, US
Sergey Epshteyn - Fremont CA, US
Timothy Patrick Forsyth - Hayward CA, US
Adam A. Galan - Alameda CA, US
Tai Phat Huynh - New York City NY, US
Mohamed Abdulkader Ibrahim - Mountain View CA, US
Henry William Beecroft Johnson - San Bruno CA, US
Brian Kane - Lynchburg VA, US
Patrick Kearney - San Francisco CA, US
Byung Gyu Kim - San Mateo CA, US
Elena S. Koltun - Foster City CA, US
James W. Leahy - San Leandro CA, US
Matthew Sangyup Lee - San Bruno CA, US
Gary L. Lewis - San Francisco CA, US
Lisa E. Meyr - Seattle WA, US
Robin Tammie Noguchi - San Bruno CA, US
Michael Pack - San Francisco CA, US
Brian Hugh Ridgway - Belmont CA, US
Xian Shi - San Bruno CA, US
John Woolfrey - Los Altos CA, US
Peiwen Zhou - Palo Alto CA, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

A61K 31/5377
C07D 413/14
A61P 7/00

US Classification:

5142358, 544122

Abstract:

This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R, R, R, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

US Patent:

20070161651, Jul 12, 2007

Filed:

Apr 8, 2004

Appl. No.:

10/552426

Inventors:

Mohamed Ibrahim - Mountain View CA, US
James Leahy - , US
Joan Sangalang - , US
Kevin Schnepp - , US
Xian Shi - , US
John Nuss - , US

Assignee:

EXELIXIS, INC. - San Francisco CA

International Classification:

A61K 31/517
A61K 31/506
C07D 403/04

US Classification:

514256000, 514266210, 544330000, 544284000

Abstract:

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

US Patent:

20060211709, Sep 21, 2006

Filed:

May 2, 2003

Appl. No.:

10/513081

Inventors:

Chris Buhr - Redwood City CA, US
Sunghoon Ma - Foster City CA, US
Zerom Tesfai - San Leandro CA, US
Longcheng Wang - South San Francisco CA, US
Erick Co - Redwood City CA, US
Sergey Epshteyn - Fremont CA, US
Abigail Kennedy - San Leandro CA, US
Baili Chen - Palo Alto CA, US
Larisa Dubenko - San Francisco CA, US
Neel Anand - Burlingame CA, US
Tsze Tsang - El Cerrito CA, US
John Nuss - Danville CA, US
Kenneth Rice - Mill Valley CA, US
Mohamed Ibrahim - Mountain View CA, US
Xian Shi - San Bruno CA, US
James Leahy - San Leandro CA, US
Jeff Chen - San Francisco CA, US
Lisa Dalrymple - San Francisco CA, US
Timothy Forsyth - Hayward CA, US
Tai Huynh - Oakland CA, US
Grace Mann - Brisbane CA, US
Larry Mann - Redwood City CA, US
Craig Takeuchi - Burlingame CA, US

International Classification:

A61K 31/497
C07D 403/02

US Classification:

514255050, 544405000

Abstract:

Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.

US Patent:

20050086022, Apr 21, 2005

Filed:

Oct 15, 2003

Appl. No.:

10/685667

Inventors:

Lance Lindberg - Redmond WA, US
Suryanarayana Putrevu - Sammamish WA, US
Mohamed Ibrahim - Bellevue WA, US
Liming Ren - Redmond WA, US
Krishna Sunkammurali - Sammamish WA, US
Ivan Santa Maria Filho - Redmond WA, US

International Classification:

G06F019/00

US Classification:

702123000

Abstract:

A system for testing software may include a driver, dispatcher and one or more executors. One or group of test cases may be provided to the testing system. Each test case includes one or more actions and may be in the form of an XML document. Each action may be dependent on or independent of previous or following actions. In preparation for executing the test case one or more times, system initialization is performed. One or more iterations of the test case may be executed and housekeeping tasks may be performed in preparation for executing the next test case. Executing an iteration of a test case includes initialization in preparation for executing the iteration, performing the actions that test the software and validating the results (including comparing the actual result with an expected result and making entries to a log) and performing local cleanup (i.e., cleanup relevant to the iteration).