- New York NY, US Sarah Xuelian Huang - New York NY, US Ya-Wen Chen - New York NY, US Jahar Bhattacharya - New York NY, US Mohammad Naeem Islam - Jamaica NY, US
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - NEW YORK NY
International Classification:
C12N 5/071 G01N 33/50 G01N 33/68
Abstract:
Embodiments of the present invention are directed to various methods for generating airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres, and to populations of cells made using the methods. The airway and lung progenitors and epithelial cells can be used as a model to study diseases that primarily affect airway epithelial cells, and to study human lung development. Methods are also provided for drug screening. Anterior foregut spheres can be used as a model for lung fibrosis.