Mohammad M Islam

US Patent:

20150247124, Sep 3, 2015

Filed:

Jul 24, 2013

Appl. No.:

14/417273

Inventors:

- New York NY, US
Sarah Xuelian Huang - New York NY, US
Ya-Wen Chen - New York NY, US
Jahar Bhattacharya - New York NY, US
Mohammad Naeem Islam - Jamaica NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - NEW YORK NY

International Classification:

C12N 5/071
G01N 33/50
G01N 33/68

Abstract:

Embodiments of the present invention are directed to various methods for generating airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres, and to populations of cells made using the methods. The airway and lung progenitors and epithelial cells can be used as a model to study diseases that primarily affect airway epithelial cells, and to study human lung development. Methods are also provided for drug screening. Anterior foregut spheres can be used as a model for lung fibrosis.