The present invention relates to methods of treating a cancerous tumor in a subject comprising administering to the subject an effective amount of 3-bromopyruvate. The 3-bromopyruvate may be administered intraarterially directly to a tumor as a continuous intraarterial infusion. The present invention also relates to methods for identifying agents that inhibit type II hexokinase activity.
Methods Of Treatment Using 3-Bromopyruvate And Other Selective Inhibitors Of Atp Production
The present invention provides methods for preventing or treating infections, especially bacterial infections, by administering selective inhibitors of ATP production to inhibit glycolytic enzymes, such as glyceraldehyde 3-phosphate dehydrogenase (GAPDH). As such, the present invention further provides methods for preventing or treating inflammation and sepsis associated with infections, as well as increased wound healing and decreased wound scarring.
Methods And Compositions For Administration Of 3-Halopyruvate And Related Compounds For The Treatment Of Cancer
Jean-Francois Geschwind - Potomac MD, US Mustafa Vali - Baltimore MD, US
International Classification:
A61K 31/22 A61P 35/04
US Classification:
514546
Abstract:
The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to pH of 2 and less than or equal to a pH of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds.
Methods And Compositions For Administration Of 3-Halopyruvate And Related Compounds For The Treatment Of Cancer
- Baltimore MD, US Mustafa Vali - Baltimore MD, US
International Classification:
A61K 31/19 A61K 47/02 A61K 45/06
Abstract:
The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to pH of 2 and less than or equal to a pH of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds.
Methods Of Treatment Using 3-Bromopyruvate And Other Selective Inhibitors Of Atp Production
- Wilmington DE, US Mustafa Vali - Baltimore MD, US
International Classification:
A61K 31/19 A01N 37/42 A61K 45/06
Abstract:
The present invention provides methods for preventing or treating infections, especially bacterial infections, by administering selective inhibitors of ATP production to inhibit glycolytic enzymes, such as glyceraldehyde 3-phosphate dehydrogenase (GAPDH). As such, the present invention further provides methods for preventing or treating inflammation and sepsis associated with infections, as well as increased wound healing and decreased wound scarring.