Mustafa S Vali from 234 Holliday St APT 201, Baltimore, MD 21202

Therapeutics For Cancer Using 3-Bromopyruvate And Other Selective Inhibitors Of Atp Production
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US Patent:

20100203110, Aug 12, 2010
Filed:

Dec 17, 2007
Appl. No.:

12/519957
Inventors:

Jean-Francois Geschwind - Potomac MD, US
Mustafa Vali - Baltimore MD, US
Assignee:

The Johns Hopkins University - Baltimore MD
International Classification:

A61K 38/21
A61K 31/19
A61K 31/53
A61K 38/50
A61K 35/74
A61K 31/255
A61K 31/282
A61K 31/195
A61K 31/7076
A61K 31/675
A61K 31/7068
A61K 31/655
A61K 38/12
A61K 31/65
A61K 31/573
A61K 31/7048
A61K 31/7072
A61K 31/513
A61K 31/437
A61K 31/519
A61K 31/429
A61K 31/52
A61K 31/475
A61K 9/127
A61P 35/00
US Classification:

424450, 514557, 514245, 424 946, 424 9346, 514517, 514492, 514567, 514 46, 514 90, 514 49, 514151, 514 9, 514154, 514171, 514 27, 514 50, 514274, 424 857, 514283, 514249, 514368, 5142633, 514 83, 514285
Abstract:

The present invention relates to methods of treating a cancerous tumor in a subject comprising administering to the subject an effective amount of 3-bromopyruvate. The 3-bromopyruvate may be administered intraarterially directly to a tumor as a continuous intraarterial infusion. The present invention also relates to methods for identifying agents that inhibit type II hexokinase activity.

Methods Of Treatment Using 3-Bromopyruvate And Other Selective Inhibitors Of Atp Production
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US Patent:

20130046019, Feb 21, 2013
Filed:

Oct 23, 2012
Appl. No.:

13/658696
Inventors:

Mustafa Vali - Baltimore MD, US
Assignee:

PRESCIENCE LABS, LLC - Wilmington DE
International Classification:

A61K 31/19
A61P 31/04
A61P 31/10
A61P 17/02
A61P 33/00
A61P 35/00
A61P 29/00
A61P 31/00
A61P 31/12
US Classification:

514557
Abstract:

The present invention provides methods for preventing or treating infections, especially bacterial infections, by administering selective inhibitors of ATP production to inhibit glycolytic enzymes, such as glyceraldehyde 3-phosphate dehydrogenase (GAPDH). As such, the present invention further provides methods for preventing or treating inflammation and sepsis associated with infections, as well as increased wound healing and decreased wound scarring.

Methods And Compositions For Administration Of 3-Halopyruvate And Related Compounds For The Treatment Of Cancer
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US Patent:

20100137434, Jun 3, 2010
Filed:

Aug 21, 2009
Appl. No.:

12/583598
Inventors:

Jean-Francois Geschwind - Potomac MD, US
Mustafa Vali - Baltimore MD, US
International Classification:

A61K 31/22
A61P 35/04
US Classification:

514546
Abstract:

The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to pH of 2 and less than or equal to a pH of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds.

Methods And Compositions For Administration Of 3-Halopyruvate And Related Compounds For The Treatment Of Cancer
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US Patent:

20170224641, Aug 10, 2017
Filed:

Oct 3, 2016
Appl. No.:

15/284014
Inventors:

- Baltimore MD, US
Mustafa Vali - Baltimore MD, US
International Classification:

A61K 31/19
A61K 47/02
A61K 45/06
Abstract:

The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to pH of 2 and less than or equal to a pH of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds.

Methods Of Treatment Using 3-Bromopyruvate And Other Selective Inhibitors Of Atp Production
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US Patent:

20150359764, Dec 17, 2015
Filed:

Aug 26, 2015
Appl. No.:

14/836649
Inventors:

- Wilmington DE, US
Mustafa Vali - Baltimore MD, US
International Classification:

A61K 31/19
A01N 37/42
A61K 45/06
Abstract:

The present invention provides methods for preventing or treating infections, especially bacterial infections, by administering selective inhibitors of ATP production to inhibit glycolytic enzymes, such as glyceraldehyde 3-phosphate dehydrogenase (GAPDH). As such, the present invention further provides methods for preventing or treating inflammation and sepsis associated with infections, as well as increased wound healing and decreased wound scarring.