Nachiappan N Chidambaram from 8410 S Handcart Cir, Sandy, UT 84070, age 56

Us Patents

Controlled Release Preparation
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US Patent:

20060115527, Jun 1, 2006
Filed:

Jan 17, 2006
Appl. No.:

11/275563
Inventors:

Emadeldin Hassan - Greensboro NC, US
Nachiappan Chidambaram - High Point NC, US
Aqeel Fatmi - Greensboro NC, US
International Classification:

A61K 31/522
A61K 9/52
A61K 31/195
A61K 31/415
A61K 31/192
US Classification:

424457000, 514263310, 514406000, 514567000, 514570000, 514569000
Abstract:

Controlled release preparations and capsules are provided. Also provided are emulsions and suspensions, including compositions and methods of manufacturing controlled release capsules, where the fill contains a suspension and/or an emulsion.

Enteric Composition For The Manufacture Of Soft Capsule Wall
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US Patent:

20060165778, Jul 27, 2006
Filed:

Jun 27, 2003
Appl. No.:

10/529984
Inventors:

Emadeldin Hassan - Greensboro NC, US
Aqeel Fatmi - Greensboro NC, US
Nachiappan Chidambaram - High Point NC, US
International Classification:

A61K 9/64
US Classification:

424456000
Abstract:

A gel mass is provided that is useful in manufacturing enteric soft or hard capsules, or enteric tablets without coating.

Solvent System For Enhancing The Solubility Of Pharmaceutical Agents
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US Patent:

20070053868, Mar 8, 2007
Filed:

Mar 3, 2006
Appl. No.:

11/367238
Inventors:

Nachiappan Chidambaram - High Point NC, US
Aqeel Fatmi - Greensboro NC, US
International Classification:

A61K 31/765
US Classification:

424078380
Abstract:

Liquid and semi-solid pharmaceutical compositions, which can be administered in liquid form or can be used for preparing capsules, are described herein. The composition comprises the salt of one ore more active agents, polyethylene glycol, 0.2-1.0 mole equivalents of a de-ionizing agent per mole of active agent, and water. The pH of the composition is adjusted within the range of 2.5-7.5. The de-ionizing agent causes partial de-ionization (neutralization) of the salt of the active agent resulting in enhanced bioavailability of salts of weakly acidic, basic or amphoteric active agents as well as lesser amounts of polyethylene glycol (PEG) esters.

Enteric Valproic Acid
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US Patent:

20070082046, Apr 12, 2007
Filed:

Oct 11, 2005
Appl. No.:

11/247389
Inventors:

Nachiappan Chidambaram - High Point NC, US
Aqeel Fatmi - Greensboro NC, US
International Classification:

A61K 9/64
A61K 31/19
US Classification:

424456000, 514557000
Abstract:

An enteric valproic acid soft gelatin capsule, in which the enteric polymer is a component of the capsule shell rather than a coating, has been developed. The fill material comprises valproic acid or divalproex sodium and, optionally, one or more pharmaceutically acceptable excipients such as corn oil. The capsule shell is prepared from a mass comprising a film-forming polymer, an acid insoluble polymer, an aqueous solvent, and optionally a plasticizer. Suitable film-forming polymers include gelatin. Suitable acid-insoluble polymers include acrylic-acid/methacrylic acid copolymers. The acid-insoluble polymer is present in an amount from about 8% to about 20% by weight of the wet gel mass. The weight ratio of acid-insoluble polymer to film-forming polymer is from about 25% to about 50%. The aqueous solvent is water or an aqueous solution of alkalis such as ammonia or diethylene amine or hydroalcoholic solutions of the same. Suitable plasticizers include glycerin and triethylcitrate. The enteric soft gelatin capsule does not require an enteric coating and thus is not susceptible to the processing problems associated with enteric coated dosage forms. Enteric valproic acid soft gelatin capsules may be smaller in size and thus easier to swallow than currently available enteric coated tablets due to the presence of fewer ingredients, as well as smaller amounts of ingredients, in the capsule shell.

Enteric Valproic Acid
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US Patent:

20070098786, May 3, 2007
Filed:

Oct 11, 2006
Appl. No.:

11/548607
Inventors:

Nachiappan Chidambaram - High Point NC, US
Aqeel Fatmi - Greensboro NC, US
International Classification:

A61K 9/64
A61K 31/19
US Classification:

424456000, 514557000
Abstract:

An enteric valproic acid soft gelatin capsule, in which the enteric polymer is a component of the capsule shell rather than a coating, has been developed. The fill material comprises valproic acid or divalproex sodium and, optionally, one or more pharmaceutically acceptable excipients such as corn oil. The capsule shell is prepared from a mass comprising a film-forming polymer, an acid insoluble polymer, an aqueous solvent, and optionally a plasticizer. Suitable film-forming polymers include gelatin. Suitable acid-insoluble polymers include acrylic-acid/methacrylic acid copolymers. The acid-insoluble polymer is present in an amount from about % to about % by weight of the wet gel mass. The weight ratio of acid-insoluble polymer to film-forming polymer is from about % to about %. The aqueous solvent is water or an aqueous solution of alkalis such as ammonia or diethylene amine or hydroalcoholic solutions of the same. Suitable plasticizers include glycerin and triethylcitrate. The enteric soft gelatin capsule does not require an enteric coating and thus is not susceptible to the processing problems associated with enteric coated dosage forms. Enteric valproic acid soft gelatin capsules may be smaller in size and thus easier to swallow than currently available enteric coated tablets due to the presence of fewer ingredients, as well as smaller amounts of ingredients in the capsule shell.

Gastric Reflux Resistant Dosage Forms
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US Patent:

20070148248, Jun 28, 2007
Filed:

Dec 22, 2005
Appl. No.:

11/316830
Inventors:

Nachiappan Chidambaram - High Point NC, US
International Classification:

A61K 9/14
US Classification:

424488000
Abstract:

Gastric resistant film-forming compositions are described herein. The composition comprises a gastric resistant natural polymer, a film-forming natural polymer, and optionally a gelling agent. Suitable gastric resistant natural polymers include polysaccharides such as pectin and pectin-like polymers. The film-forming composition can be used to prepare soft or hard shell gelatin capsules which can encapsulate a liquid or semi-solid fill material or a solid tablet (Softlet) comprising an active agent and one or more pharmaceutically acceptable excipients. Alternatively, the composition can be administered as a liquid with an active agent dissolved or dispersed in the composition. The compositions are not only gastric resistant but may also prevent gastric reflux associated with odor causing liquids, such as fish oil or garlic oil, encapsulated in a unit dosage form and esophageal irritation due to the reflux of irritant drugs delivered orally.

Gastric Reflux Resistant Dosage Forms
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US Patent:

20100158958, Jun 24, 2010
Filed:

Mar 3, 2010
Appl. No.:

12/716593
Inventors:

Nachiappan Chidambaram - Salt Lake City UT, US
International Classification:

A61K 35/60
A61K 36/8962
A61K 36/48
A61K 31/25
A61P 3/02
B29C 39/02
A61K 47/42
A61K 9/00
US Classification:

424400, 424523, 424754, 424757, 514547, 264299, 514774
Abstract:

Gastric resistant film-forming compositions are described herein. The composition comprises a gastric resistant natural polymer, a film-forming natural polymer, and optionally a gelling agent. Suitable gastric resistant natural polymers include polysaccharides such as pectin and pectin-like polymers. The film-forming composition can be used to prepare soft or hard shell gelatin capsules which can encapsulate a liquid or semi-solid fill material or a solid tablet (Softlet) comprising an active agent and one or more pharmaceutically acceptable excipients. Alternatively, the composition can be administered as a liquid with an active agent dissolved or dispersed in the composition. The compositions are not only gastric resistant but may also prevent gastric reflux associated with odor causing liquids, such as fish oil or garlic oil, encapsulated in a unit dosage form and esophageal irritation due to the reflux of irritant drugs delivered orally.

Steroidal Compositions
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US Patent:

20100173882, Jul 8, 2010
Filed:

Jan 8, 2009
Appl. No.:

12/350930
Inventors:

Chandrashekar Giliyar - Salt Lake City UT, US
Nachiappan Chidambaram - Sandy UT, US
Mahesh V. Patel - Salt Lake City UT, US
Srinivasan Venkateshwaran - Salt Lake City UT, US
Assignee:

LIPOCINE, INC. - Salt Lake City UT
International Classification:

A61K 31/568
A61P 5/26
US Classification:

514178
Abstract:

Provided herein are steroid containing compositions suitable for providing therapeutically effective amounts of at least one steroid to individuals. Also provided herein are compositions comprising testosterone and/or testosterone derivatives suitable for providing therapeutically effective and safe amounts of testosterone over periods of time. Further provided are methods of treating andro- and/or testosterone deficiency in individuals by administering to the individuals compositions described herein.