Ramesh C. Pandey - Highland Park NJ Luben K. Yankov - Edison NJ Raghu Nair - Bridgewater NJ Alex Pouley - Highland Park NJ
Assignee:
Xechem International, Inc. - New Brunswick NJ
International Classification:
A61K 31335 C07D30514
US Classification:
514449
Abstract:
Provided are novel paclitaxel analogues, namely selectively brominated stereospecific derivatives of cephalomannine and 7-epi-cephalomannine having in vivo and in vitro paclitaxel-like antitumor efficacy, methods of preparation therefor and methods for treating tumors with these compounds.
Preparation Of Chlorinated Paclitaxel Analogues And Use Thereof As Antitumor Agents
Ramesh C. Pandey - Highland Park NJ Luben K. Yankov - Edison NJ Raghu Nair - Bridgewater NJ Alex Poulev - Highland Park NJ
Assignee:
Xechem International, Inc. - New Brunswick NJ
International Classification:
A61K 31335 C07D30514
US Classification:
514449
Abstract:
Provided are novel paclitaxel analogues which are selectively chlorinated stereospecific derivatives of cephalomannine and 7-epi-cephalomannine having paclitaxel-like antitumor efficacy, methods for their preparation and methods for treating tumors with these compounds.