Metta Health Center 135 Jackson St, Lowell, MA 01852 (978)4411700 (phone), (978)4541681 (fax)
Languages:
English Korean Spanish Vietnamese
Description:
Dr. Colburn works in Lowell, MA and specializes in Psychologist. Dr. Colburn is affiliated with Lowell General Hospital and Lowell General Hospital Saints Campus.
Curtis J. Henrich - Rockville MD, US Moon-Il Kang - Gyeongsangnam-do, KR Heidi R. Bokesch - Frederick MD, US Kirk R. Gustafson - Frederick MD, US Nancy H. Colburn - Middletown MD, US Matthew R. Young - Ijamsville MD, US James B. McMahon - Frederick MD, US
Assignee:
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES - Bethesda MD
An embodiment of the invention provides a pharmaceutical composition comprising a compound of formula (I)a pharmaceutically acceptable salt, prodrug, hydrate, or solvate thereof. Another embodiment of the invention provides a method of treating or preventing a condition associated with increased expression and/or activity of an NFκB pathway using same compounds. A further embodiment of the invention provides a method of diagnosing a condition in an individual using same compounds.
Dominant Negative Deletion Mutants Of C-Jun And Their Use In The Prevention And Treatment Of Cancer
Nancy H. Colburn - Middletown MD Zigang Dong - Frederick MD Powel H. Brown - North Potomac MD Michael J. Birrer - Potomac MD
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A01N 4304
US Classification:
514 44, 424 932
Abstract:
The inhibition of AP-1 activity by dominant negative deletion mutants of c-jun is disclosed. This inhibition of AP-1 activity is shown to be associated with inhibition of tumor promoter-induced neoplastic transformation. Therefore, the invention relates to the utilization of dominant negative deletion mutants of c-jun which are inhibitory to tumor promotor-induced neoplastic transformation as therapeutic agents in the prevention and treatment of cancer in mammals.
Isbn (Books And Publications)
Genes and Signal Transduction in Multistage Carcinogenesis
Growth Factors, Tumor Promoters, and Cancer Genes: Proceedings of a Triton Biosciences-UCLA Symposium Held in Steamboat Springs, Colorado, April 6-13, 1986