Nancy A Hosken

US Patent:

6426072, Jul 30, 2002

Filed:

Aug 21, 2000

Appl. No.:

09/643597

Inventors:

Tongtong Wang - Medina WA
Liqun Fan - Bellevue WA
Michael D. Kalos - Seattle WA
Chaitanya S. Bangur - Seattle WA
Nancy A. Hosken - Seattle WA
Gary R. Fanger - Mill Creek WA
Samuel X. Li - Redmond WA
Aijun Wang - Issaquah WA
Yasir A. W. Skeiky - Bellevue WA
Robert A. Henderson - Edmonds WA
Patricia D. McNeill - Des Moines WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A61K 3900

US Classification:

4241841, 536 231, 536 234, 4353201, 530300, 530350, 4241851

Abstract:

Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

US Patent:

6482597, Nov 19, 2002

Filed:

Jan 10, 2000

Appl. No.:

09/480884

Inventors:

Tongtong Wang - Medina WA
Nancy A. Hosken - Seattle WA
Michael D. Kalos - Seattle WA
Gary R. Fanger - Mill Creek WA
Liqun Fan - Bellevue WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

G01N 3353

US Classification:

435 71, 435 723, 5303871, 5303881, 4241301, 4241411, 4241551

Abstract:

Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

US Patent:

6518256, Feb 11, 2003

Filed:

Apr 4, 2000

Appl. No.:

09/542615

Inventors:

Tongtong Wang - Medina WA
Liqun Fan - Bellevue WA
Michael D. Kalos - Seattle WA
Chaitanya S. Bangur - Seattle WA
Nancy A. Hosken - Seattle WA
Gary R. Fanger - Mill Creek WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A01N 4304

US Classification:

514 44, 4353201, 435325, 435455, 536 231, 536 235, 4241841

Abstract:

Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

US Patent:

6531315, Mar 11, 2003

Filed:

Jun 28, 2000

Appl. No.:

09/606421

Inventors:

Tongtong Wang - Medina WA
Liqun Fan - Bellevue WA
Michael D. Kalos - Seattle WA
Chaitanya S. Bangur - Seattle WA
Nancy A. Hosken - Seattle WA
Gary R. Fanger - Mill Creek WA
Samuel X. Li - Redmond WA
Aijun Wang - Issaquah WA
Yasir A. W. Skeiky - Bellevue WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C12N 508

US Classification:

4353723, 435326, 4241841, 42418511

Abstract:

Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

US Patent:

6537555, Mar 25, 2003

Filed:

Jun 28, 2001

Appl. No.:

09/894998

Inventors:

Nancy A. Hosken - Seattle WA
Craig H. Day - Seattle WA
Davin C. Dillon - Issaquah WA
Patrick McGowan - Seattle WA
Paul R. Sleath - Seattle WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A61K 3912

US Classification:

4241991, 4242311, 4241841, 4241861, 4242041, 435 6, 4353201, 435325, 4352351, 536 2372

Abstract:

Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits are also provided comprising such polypeptides and/or DNA sequences and a suitable detection reagent for the detection of HSV infection in patients and in biological samples.

US Patent:

6706262, Mar 16, 2004

Filed:

Dec 30, 1999

Appl. No.:

09/476496

Inventors:

Tongtong Wang - Medina WA
Nancy A. Hosken - Seattle WA
Michael D. Kalos - Seattle WA
Gary R. Fanger - Mill Creek WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A01N 6300

US Classification:

424 932, 536 235, 4353201, 435325, 435455

Abstract:

Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

US Patent:

6737514, May 18, 2004

Filed:

Aug 2, 2000

Appl. No.:

09/630940

Inventors:

Tongtong Wang - Medina WA
Liqun Fan - Bellevue WA
Michael D. Kalos - Seattle WA
Chaitanya S. Bangur - Seattle WA
Nancy A. Hosken - Seattle WA
Gary R. Fanger - Mill Creek WA
Samuel X. Li - Redmond WA
Aijun Wang - Issaquah WA
Yasir A. W. Skeiky - Bellevue WA
Robert A. Henderson - Edmonds WA
Patricia D. McNeill - Des Moines WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C07K 1600

US Classification:

5303877, 4241301, 4241781, 530300, 530350, 536 231

Abstract:

Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

US Patent:

6814969, Nov 9, 2004

Filed:

Jul 31, 2002

Appl. No.:

10/210428

Inventors:

David M. Koelle - Seattle WA
Nancy A. Hosken - Seattle WA
Christine M. Posavad - Seattle WA
Hongbo Chen - Shoreline WA
Patrick McGowan - Seattle WA

Assignee:

University of Washington - Seattle WA

International Classification:

A61K 39245

US Classification:

4242291, 4242311, 4241861, 435 6, 435 9133, 536 2372

Abstract:

The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.