Nancy E Kaufman

US Patent:

45967237, Jun 24, 1986

Filed:

May 2, 1984

Appl. No.:

6/606387

Inventors:

Nancy K. Kaufman - Belmont CA
Richard A. Harte - Redwood City CA
Anthony B. Chen - Hayward CA

Assignee:

Daryl Laboratories, Inc. - Santa Clara CA

International Classification:

B05D 302
G01N 3354

US Classification:

427336

Abstract:

Preparation of an immunoassay gel substrate which includes the steps of depositing on an immobilizing support structure a liquid mass of a gel-forming emulsion which coalesces into a thick gel-like matrix film characterized by substantial non-agglomerated matrix homogeneity, treating the resulting film to alter matrix homogeneity by agglomerating particles which form part of the gel, and as a consequence of the treating step establishing the object gel. Treating may be performed either by subjecting the gel to multiple time-vigorous water-wash and dry cycles, by emersing the gel in water for a relatively long period of time, or by wetting the gel and then subjecting it to one or more freeze/thaw cycles.

US Patent:

D2798174, Jul 23, 1985

Filed:

Jul 19, 1982

Appl. No.:

6/399855

Inventors:

Anthony B. Chen - Hayward CA
Richard A. Harte - Redwood City CA
Nancy K. Kaufman - Belmont CA

Assignee:

Daryl Laboratories, Inc. - Santa Clara CA

US Classification:

D24 29

US Patent:

44683715, Aug 28, 1984

Filed:

Jul 19, 1982

Appl. No.:

6/399920

Inventors:

Anthony B. Chen - Hayward CA
Richard A. Harte - Redwood City CA
Nancy K. Kaufman - Belmont CA

Assignee:

Daryl Laboratories, Inc. - Santa Clara CA

International Classification:

G01N 3354
G01N 3500
G01N 3502

US Classification:

422102

Abstract:

A test slide for the performance of a series of immunoassay tests having: a substantially elongated and thin body of solid material; a plurality of individual test wells formed in said body; alignment means formed in said body in association with each of said wells; and movement facilitating means formed in said body; said slide being suitable for insertion into an automated testing device, said slide moving by said movement facilitating means, and said wells being aligned for detection by said alignment means.

US Patent:

45406600, Sep 10, 1985

Filed:

Apr 7, 1983

Appl. No.:

6/483055

Inventors:

Richard A. Harte - Redwood City CA
Anthony B. Chen - Hayward CA
Nancy K. Kaufman - Belmont CA

Assignee:

Daryl Laboratories, Inc. - Santa Clara CA

International Classification:

G01N 3354

US Classification:

435 7

Abstract:

A substrate for fluoroimmunoassay is disclosed comprising a swellable, rehydratable polymeric protein-binding material forming a three-dimensional matrix; first particulate, light scattering centers distributed in the polymeric matrix capable of scattering visible light; and second particulate, light-scattering centers distributed in the polymeric matrix capable of reflecting fluorescent excitation light and absorbing all other light. The substrate efficiently binds proteins and enhances transmitted fluorescent light and thus increases the sensitivity of assays involving fluorescent measurements. The polymeric protein binding material is preferable an acrylic copolymer. The first light scattering centers are preferably oxides of titanium and zinc, and the second light-scattering centers are preferably a phthalocyanin compound.