Nancy J Larsen

US Patent:

7034127, Apr 25, 2006

Filed:

Jul 1, 2003

Appl. No.:

10/611439

Inventors:

Edward G. Parent - North Bergen NJ, US
Nancy E. Larsen - Highland Mills NY, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

C07K 1/00
C07K 14/00
C07K 16/00
C07K 17/00

US Classification:

530402, 514 2, 514 54, 514 56, 514 57, 530410, 525 541, 525 542, 536 21, 536 54, 536 84

Abstract:

Disclosed are methods of conjugating biologically active substances, particularly, alpha-interferon, with a hyaluronan or a mixture of a hyaluronan with at least one other hydrophilic polymer having a functional group capable of reacting with divinyl sulfone. Also disclosed are stable intermediates formed by partially reacting a hyaluronan with divinyl sulfone and stopping the reaction before completion to leave free, or reactive vinyl groups on the hyaluronan molecule available for conjugation with the biologically active substance.

US Patent:

7521434, Apr 21, 2009

Filed:

Jun 27, 2006

Appl. No.:

11/475200

Inventors:

Adelya K. Leshchiner - Cresskill NJ, US
Nancy E. Larsen - Highland Mills NY, US
Edward G. Parent - North Bergen NJ, US

Assignee:

Luromed LLC - Tarrytown NY

International Classification:

A61K 31/728
A61K 31/715

US Classification:

514 54, 514 23, 5361231, 536124

Abstract:

The present invention provides for compositions of hyaluronic acid cross-linked with at least one other hydrophobic polymer to form a copolymer gel. The preferred composition is a formulation containing hyaluronic acid or its derivatives and a silicone base polymer with a functional group capable of reacting with the preferred cross-linker. The silicon may also be a group capable of undergoing further polymerization, or a silicone moiety adding to the hydrophobic nature of the gel. The product can be used alone or contain various other substances or covalently bound substances for numerous useful applications including cosmetic, medical, and drug delivery applications. The present invention also provides processes for preparing them.

US Patent:

8247390, Aug 21, 2012

Filed:

Sep 28, 2009

Appl. No.:

12/586716

Inventors:

Adelya K. Leshchiner - Cresskill NJ, US
Nancy E. Larsen - Highland Mills NY, US
Edward G. Parent - North Bergen NJ, US

Assignee:

LuroMed LLC - Orangeburg NY

International Classification:

A01N 43/04
A61K 31/715

US Classification:

514 54, 424 59

Abstract:

Disclosed are hydrophilic polymers such as polysaccharides, including hyaluronic acid of any origin, modified by reaction with epoxy-functional-silicones. Hydrophobic silicon, which contains chemically active groups covalently attach to the backbone of the hydrophilic polymer and gives these new, modified polymers the ability to dissolve hydrophobic compounds including oils, drugs, and vitamins, while maintaining the hydrophilic properties and benefits of the unmodified polymer. With respect to topical applications these polymers substantially increase the stability of formulations and provide for ease of preparation. The properties and advantages of the original polymer are maintained while other properties are augmented, namely the ability to combine with or dissolve hydrophobic and hydrophilic drugs. The products can be used alone or in combination with other substances for various applications including cosmetic, medical, and drug delivery applications. Also disclosed are methods for preparing them.

US Patent:

20060280809, Dec 14, 2006

Filed:

Jun 14, 2006

Appl. No.:

11/452372

Inventors:

Adele Leshchiner - Cresskill NJ, US
Nancy Larsen - Highland Mills NY, US
Edward Parent - North Bergen NJ, US

International Classification:

A61K 33/36
A61K 31/727
A61K 31/16
A61K 31/728
A61K 31/737
A61K 31/573
A61K 36/899
A61K 36/47
A61K 36/28
A61K 36/72
A61K 36/185

US Classification:

424672000, 424731000, 424750000, 424764000, 424765000, 424778000, 514054000, 514056000, 514171000, 514629000

Abstract:

Otic and nasal compositions containing any iodine-containing derivatives, including, free iodine and iodoform, are disclosed. lodoform is a potent germicidal agent which provides anti-infective benefits. The composition also contains one or more anti-inflammatory agents and one or more natural or synthetic compounds which provide analgesic benefits. The composition preferably also contains one or more natural or synthetic compounds which provides aromatic benefits. The composition may be utilized to treat otic and nasal conditions, including otitis media, by topically applying the composition to the affected tissue.

US Patent:

20100135935, Jun 3, 2010

Filed:

Nov 28, 2008

Appl. No.:

12/315087

Inventors:

Adelya K. Leshchiner - Cresskill NJ, US
Nancy E. Larsen - Highland Mills NY, US
Edward G. Parent - North Bergen NJ, US

International Classification:

A61K 47/30
A61K 47/36
A61K 47/42
A61K 38/18
A61K 8/73
A61K 31/56
A61K 31/573
A61K 38/12
A61K 31/79

US Classification:

424 59, 514777, 5147723, 514773, 514 12, 514179, 514177, 514 9, 424 7802

Abstract:

Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.

US Patent:

52466981, Sep 21, 1993

Filed:

Dec 20, 1991

Appl. No.:

7/811139

Inventors:

Edward Leshchiner - Cresskill NJ
Endre A. Balazs - Fort Lee NJ
Nancy E. Larsen - Highland Mills NY
Adelya Leshchiner - Cresskill NJ

Assignee:

Biomatrix, Inc. - Ridgefield NJ

International Classification:

A61K 3174
A61K 3702
A61K 31715

US Classification:

424 7808

Abstract:

Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but not necessarily be a hyaluronan or derivative thereof. Also disclosed are methods of making such slurries, controlling their rheological properties and the uses thereof.

US Patent:

51283263, Jul 7, 1992

Filed:

Jul 23, 1990

Appl. No.:

7/559413

Inventors:

Endre A. Balazs - Ft. Lee NJ
Adolf Leshchiner - Fairview NJ
Nancy E. Larsen - Ridgefield Park NJ

Assignee:

Biomatrix, Inc. - Ridgefield NJ

International Classification:

A61K 31715
A61K 970
A61F 1300

US Classification:

514 54

Abstract:

Disclosed are drug delivery systems based on a polymeric component which is soluble or insoluble (cross-linked) hyaluronan or hyaluronan copolymerized with another hydrophilic polymer or hylan and one or more substances having biological or pharmacological activity and methods of preparing same.

US Patent:

53993519, Mar 21, 1995

Filed:

Jun 24, 1993

Appl. No.:

8/080629

Inventors:

Edward Leshchiner - Cresskill NJ
Endre A. Balazs - Fort Lee NJ
Nancy E. Larsen - Highland Mills NY
Adelva Leshchiner - Cresskill NJ

Assignee:

Biomatrix, Inc. - Ridegefireld NJ

International Classification:

A61K 3174
A61K 3179
A61K 31715

US Classification:

424422

Abstract:

Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but not necessarily be a hyaluronan or derivative thereof. Also disclosed are methods of making such slurries, controlling their rheological properties and the uses thereof.