Nancy K Strathy

US Patent:

58664106, Feb 2, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/474933

Inventors:

Michael J. Ryan - West Milford NJ
Jason A. Lotvin - Union NJ
Nancy Strathy - Monsey NY
Susan E. Fantini - Ridgewood NJ

Assignee:

American Cyanamid Company - Madison NJ

International Classification:

C12N 1500

US Classification:

4353201

Abstract:

The present invention describes a purified and isolated nucleic acid molecule which encodes for the biosynthetic pathway of tetracycline, chlortetracycline or an analogue thereof. The invention relates to the isolation and cloning of the nucleic acid molecule in an isolated fragment from Streptomyces aureofaciens and the expression of the biosynthetic gene in a heterologous host such as Streptomyces lividans.

US Patent:

55893856, Dec 31, 1996

Filed:

Sep 22, 1993

Appl. No.:

8/125468

Inventors:

Michael J. Ryan - West Milford NJ
Jason A. Lotvin - Union NJ
Nancy Strathy - Monsey NY
Susan E. Fantini - Ridgewood NJ

Assignee:

American Cyanamid Company - Wayne NJ

International Classification:

C12N 121
C12N 1552
C12N 1576

US Classification:

43525835

Abstract:

The present invention describes a purified and isolated nucleic acid molecule which encodes for the biosynthetic pathway of tetracycline, chlortetracycline or an analogue thereof. The invention relates to the isolation and cloning of the nucleic acid molecule in an isolated fragment from Streptomyces aureofaciens and the expression of the biosynthetic gene in a heterologous host such as Streptomyces lividans.