Michel M. Chartrain - Westfield NJ Neal C. Connors - Fanwood NJ George M. Garrity - Westfield NJ Roger C. Olewinski - Milltown NJ Thomas R. Verhoeven - Cranford NJ Jinyou Zhang - Edison NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C12P 1702 C12P 722 C12P 102 C12P 500
US Classification:
435123
Abstract:
A process is disclosed that quantitatively bioconverts indene to (1S,2R)-indene oxide and (1S,2R)-indandiol, by the action of fungal haloperoxidase followed by various chemical step(s), e. g. , adjusting the pH.
Pseudomonas Putida Strain With Dioxygenase Activity
A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of the enzyme dioxygenase, followed by various chemical step(s), e. g. , chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.
Conversion Of Indene To (1S)-Amino-(2R)-Indanol Free Of Any Stereoisomer, By Combination Of Dioxygenase Bioconversion And Chemical Steps
Barry C. Buckland - Westfield NJ Neal C. Connors - Fanwood NJ Michel M. Chartrain - Westfield NJ Francis P. Gailliot - Cranford NJ Randolph L. Greasham - Mountainside NJ Barbara Jackey - Bloomfield NJ Brian Heimbuch - North Brunswick NJ Chanyong Lee - Princeton NJ Roger C. Olewinski - Milltown NJ F. Edward Roberts - Princeton NJ Paul J. Reider - Westfield NJ Thomas R. Verhoeven - Cranford NJ Chris H. Senanayake - North Brunswick NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C12P 1302 C12P 722 C12P 4100
US Classification:
435129
Abstract:
A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of a strain of P. putida or Rhodococcus sp. , followed by various chemical step(s), e. g. , chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.
Institute For Life Science Entrepreneurship (Ilse)
Director, Research
Kalion Jan 2010 - Aug 2017
Co-Founder and Chief Technology Officer
Society For Industrial Microbiology and Biotechnology Jul 2011 - Aug 2012
President
Drew University Jul 2011 - Aug 2012
Research Institute For Scientists Emeriti , Fellow
Phoenix Bioconsulting Jul 2011 - Aug 2012
Owner and President
Education:
The Ohio State University 1987 - 1991
Doctorates, Doctor of Philosophy, Microbiology
Norwich University 1980 - 1984
Bachelors, Bachelor of Science, Biology
Institute For Life Science Entrepreneurship (Ilse)
Skills:
Biotechnology Biochemistry Cell Culture Fermentation High Throughput Screening Microbiology Monoclonal Antibodies Drug Development Life Sciences Laboratory Lifesciences Biopharmaceuticals Clinical Development Process Simulation
Owner/President at Phoenix BioConsulting, LLC, RISE Associate at Drew University, Past-President at Society for Industrial Microbiology and Biotechnology
Location:
Greater New York City Area
Industry:
Biotechnology
Work:
Phoenix BioConsulting, LLC since Jan 2009
Owner/President
Drew University - Madison, New Jersey since Feb 2012
RISE Associate
Society for Industrial Microbiology and Biotechnology since Jul 2011
Past-President
Merck Sep 1991 - Oct 2008
Senior Investigator
Education:
The Ohio State University 1987 - 1991
Ph.D., Microbiology
Norwich University 1980 - 1984
BS, Biology (chemistry minor)
Neal Neal Connors 1981 graduate of Montini Catholic High School in Lombard, IL is on Memory Lane. Get caught up with Neal and other high school alumni from