Ngoc T Le

US Patent:

7749711, Jul 6, 2010

Filed:

Sep 11, 2003

Appl. No.:

10/527510

Inventors:

Ngoc Anh Le - Decatur GA, US
W. Virgil Brown - Atlanta GA, US

International Classification:

G01N 33/53

US Classification:

435 71, 435 72, 435 791, 435 792

Abstract:

The present invention provides methods utilizing the fat-induced antibody response (FIAR) to assess endothelial function. Additional methods are provided that utilize FIAR for diagnosing and monitoring the progression of vascular diseases, the success of treatment for these diseases, and as a measure of the oxidative stress imposed upon vascular endothelium. Still more methods are provided for measuring the oxidation products of lipids in blood following the administration of a polyunsaturated fatty acid (fat-induced acute response) to monitor the treatment success of a vascular disease, for monitoring the degree of endothelial inflammation, and for diagnosing and monitoring the progression of a cardiovascular disease.

US Patent:

20170266318, Sep 21, 2017

Filed:

Mar 18, 2016

Appl. No.:

15/074493

Inventors:

- Madison WI, US
Ngoc Nhi Le - Norcross GA, US
Michael W. Toepke - Midland MI, US
Nicholas Impellitteri - Madison WI, US
Connie Sue Chamberlain - Monona WI, US
William Leo Murphy - Waunakee WI, US

International Classification:

A61K 47/48
A61K 38/17

Abstract:

Vascular endothelial growth factor VEGF-sequestering hydrogel microspheres that have been prepared to selectively bind VEGF from blood products are disclosed herein. In one particular embodiment, the microspheres bind VEGF as part of an intra-operative process such that the growth factor can be removed from the blood products before the products are used in a clinical procedure.

US Patent:

20160175800, Jun 23, 2016

Filed:

Dec 18, 2014

Appl. No.:

14/575084

Inventors:

- Madison WI, US
Ngoc Nhi Le - Norcross GA, US

International Classification:

B01J 19/00
G01N 33/50

Abstract:

Hydrogel arrays, methods for preparing hydrogel arrays and methods for screening cell-substrate interactions using the hydrogel arrays are disclosed. Advantageously, the hydrogel arrays include individual hydrogel posts that are completely isolatable, allowing for systematic and independent control of the chemical composition and physical dimensions of each hydrogel post.

US Patent:

20150291929, Oct 15, 2015

Filed:

Apr 10, 2015

Appl. No.:

14/684062

Inventors:

- Madison WI, US
Ngoc Nhi Le - Norcross GA, US
Michael P. Schwartz - Madison WI, US
Eric Huy Dang Nguyen - Madison WI, US
Stefan Zorn - Madison WI, US
Hamisha Ardalani - Madison WI, US
Matthew Zanotelli - Muskego WI, US
Matthew Brian Parlato - Madison WI, US
David Gregory Belair - Madison WI, US
William T. Daly - Madison WI, US

International Classification:

C12N 5/00

Abstract:

Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation. In particularly suitable embodiments, the hydrogel compositions of the present disclosure may be used to promote tubulogenesis of endothelial cells.