Nicholas O Fischer

US Patent:

20100092567, Apr 15, 2010

Filed:

Oct 22, 2009

Appl. No.:

12/604362

Inventors:

PAUL D. HOEPRICH - PLEASANTON CA, US
NICHOLAS O. FISCHER - LIVERMORE CA, US
CRAIG BLANCHETTE - MORAGA CA, US

International Classification:

A61K 39/385
C07K 17/00
A61K 9/14

US Classification:

424489, 530359, 4241941

Abstract:

Provided herein are immunostimulatory nanolipoprotein particles and related compositions methods and systems.

US Patent:

20220211866, Jul 7, 2022

Filed:

Dec 23, 2021

Appl. No.:

17/561625

Inventors:

- Livermore CA, US
Nicholas O. FISCHER - LIVERMORE CA, US
Amy RASLEY - LIVERMORE CA, US
Craig D. BLANCHETTE - SAN LEANDRO CA, US
Todd PETERSON - CORONADO CA, US

International Classification:

A61K 47/69
A61P 31/04
A61K 9/00
A61K 9/127
A61K 39/02
A61K 39/39
B82Y 5/00

Abstract:

A telodendrimer-nanolipoprotein particle (t-NLP), comprising one or more membrane forming lipids, one or more telodendrimers, and a scaffold protein and a major outer membrane protein (MOMP) comprising a MOMP hydrophobic region, and related compositions methods and systems.

US Patent:

20210139828, May 13, 2021

Filed:

Nov 7, 2019

Appl. No.:

16/677328

Inventors:

- Livermore CA, US
Heather Ann ENRIGHT - Livermore CA, US
Nicholas FISCHER - Livermore CA, US
Doris Mailie LAM - Dublin CA, US
Angela C. TOOKER - Livermore CA, US
Michael TRIPLETT - Livermore CA, US
Elizabeth K. WHEELER - Livermore CA, US

International Classification:

C12M 1/32
C12N 5/00
C12M 1/42
G01N 27/30
B01L 3/00

Abstract:

The present disclosure relates to a biocompatible, in vitro probe system. The probe system may have a substrate and a culture well supported on the substrate. The culture well defines a three-dimensional volume for containing in vitro cultures of electroactive cells. The probe system has at least one probe subsystem supported on the substrate. The probe subsystem has at least one probe having an array of electrodes, with the probe being disposed within the culture well for in vitro electrically communicating with the electroactive cells. The probe subsystem is adapted to be interfaced to an external instrumentation/recording device.

US Patent:

20180318218, Nov 8, 2018

Filed:

May 2, 2018

Appl. No.:

15/969311

Inventors:

- La Jolla CA, US
Nathaniel S. Wang - San Diego CA, US
Martina Felderman - La Jolla CA, US
Bolyn Hubby - Redwood City CA, US
Heather D. Gouvis - San Diego CA, US
Nicholas O. Fischer - Livermore CA, US
Matthew A. Coleman - Oakland CA, US
Angela Clare Evans - Livermore CA, US
Wei He - Davis CA, US
Amy Rasley - Livermore CA, US
Craig D. Blanchette - San Leandro CA, US

International Classification:

A61K 9/127
A61K 48/00

Abstract:

Nanolipoprotein particles comprising at least a scaffold protein component and a membrane lipid component and related complexes, compositions, methods and systems are described, in which the membrane lipid component comprises at least one or more membrane forming lipids and one or more cationic lipids.