Nicholas Owens

US Patent:

20210033620, Feb 4, 2021

Filed:

Jul 29, 2020

Appl. No.:

16/942724

Inventors:

Marc David Porter - Park City UT, US
Lars Bjorn Laurentius - Cottonwood Heights UT, US
Nicholas Owens - Sacramento CA, US
Ryan Evan Robinson - Taylorsville UT, US

Assignee:

University of Utah - Salt Lake City UT

International Classification:

G01N 33/68
G01N 33/58

Abstract:

This invention discloses a pretreatment approach for blood and bodily fluids to remove unwanted protein interferences in the measurement of analytes. Enzymes either contained in a cartridge or immobilized on a solid support break down proteins that complex with the analyte to shield it from detection. This pretreatment significantly enhances the detectability of analytes and does not require subsequent clean-up steps that would normally be required to ensure the functionality of the analysis method, thereby, creating a simple yet powerful approach for sample pretreatment in a variety of settings ranging from a complex laboratory infrastructure to a field deployable application.