Nicholas Zavazava

US Patent:

20050287631, Dec 29, 2005

Filed:

Nov 23, 2004

Appl. No.:

10/995805

Inventors:

Martin Kroenke - Koln, DE
Nicholas Zavazava - Coralville IA, US

International Classification:

A61K038/17
C07K014/74
C07H021/04

US Classification:

435069100, 435320100, 435325000, 514012000, 530350000, 536023500

Abstract:

Embodiments of the invention include dimeric soluble MHC molecules (dsMHCs) and compositions and methods for their use. The molecules may be used to downregulate activated T cells. The dsMHCs may be administered by intraperitoneal infusion into a tissue or an organ recipient. The administration of dsMHCs molecules may also be supplemented with immunosupressant to induce the engraftment of allografts. dsMHCs molecules may also be used for visualization of alloreactive T cells in various tissues or organs.

US Patent:

20160288414, Oct 6, 2016

Filed:

Nov 4, 2014

Appl. No.:

15/034004

Inventors:

- Iowa City IA, US
Howard Chen - Iowa City IA, US
Yin Yu - Iowa City IA, US
Yahui Zhang - Iowa City IA, US
Nicholas Zavazava - Coralville IA, US
Liu Hong - Coralville IA, US
Aliasger K. Salem - Coralville IA, US
Adil Akkouch - Coralville IA, US
Kazim Kerim Moncal - Iowa City IA, US

Assignee:

UNIVERSITY OF IOWA RESEARCH FOUNDATION - Iowa City IA

International Classification:

B29C 67/00
C09D 11/102
C09D 11/04
C12M 3/00
C12M 1/26

Abstract:

A bioprinter and methods of using the bioprinter. The bioprinter permits selective three-dimensional movement of multiple nozzle assemblies during operation of the bioprinter. The bioprinter can be used to produce scaffold-free tissue constructs having a plurality of cellular elements interspersed among a semi-permeable vascular network. The bioprinter can also be used to print a tissue construct directly onto a tissue defect of a subject. The bioprinter can be provided as part of a bioprinting system that includes a scanner for imaging the tissue defect.