Nicole A O'Brien

US Patent:

20080299042, Dec 4, 2008

Filed:

May 2, 2005

Appl. No.:

11/579106

Inventors:

Pamela Bechtel - San Diego CA, US
Mark Daniels - San Diego CA, US
Karen McLachlan - Del Mar CA, US
Yufeng Zhai - San Diego CA, US
Benjamin L. Colson - Carlsbad CA, US
Nicole W. O'Brien - San Marcos CA, US

Assignee:

Biogen Idec MA Inc. - Cambridge MA

International Classification:

A61K 49/00
C40B 40/08
C40B 50/02
C07H 21/00
A61P 31/00
C07K 14/00
A61K 39/395
G01N 33/574

US Classification:

424 91, 506 17, 506 24, 4241381, 435 723, 536 235, 530350

Abstract:

The present invention is directed to novel methods of treating, identifying or diagnosing a hyperproliferative disorder in a patient in need thereof. The methods of the invention include administering to a patient a composition comprising a binding molecule which binds to a cell surface expressed glycoprotein expressed predominantly in tumor or tumor-associated cells. In particular, the therapeutic and diagnostic methods of the present invention include the use of a binding molecule, for example an antibody or immunospecific fragment thereof, which specifically binds to a membrane associated molecule, variant polypeptide or fragment thereof. The present invention is based, at least in part, on the discovery of membrane associated proteins, i.e., nucleic acid molecules which encode membrane proteins and the use of these molecules to generate custom arrays to screen for markers associated with various diseases and disorders, e.g., cancer, e.g., lung, colon, pancreatic and ovarian cancer and autoimmune diseases or disorders. The invention further relates to various methods, reagents and kits for diagnosing, staging, prognosing, monitoring and treating hyperproliferative diseases or disorders such as cancer, e.g., lung, colon, pancreatic and ovarian cancer and autoimmune diseases or disorders.

US Patent:

20060204503, Sep 14, 2006

Filed:

Jan 31, 2006

Appl. No.:

11/343271

Inventors:

Jonathon Fitchett - San Marcos CA, US
Mark Daniels - San Diego CA, US
Michael Labarre - San Diego CA, US
Karen McLachlan - Encinitas CA, US
Tony Rowe - Sandringham, AU
Nicole O'Brien - San Marcos CA, US
Samuel Cho - San Diego CA, US
Melissa Heller - San Diego CA, US

Assignee:

Biogen Idec MA Inc. - Cambridge MA

International Classification:

A61K 39/395
C07K 16/30
C40B 40/10
C12P 21/04

US Classification:

424155100, 530388800, 435007100, 435070210

Abstract:

The present invention is directed to novel methods of treating, indentifying or diagnosing a hyperproliferative disorder in a patient in need thereof. The methods of the invention include administering to a patient a composition comprising a binding molecule which binds to a cell surface expressed glycoprotein expressed predominantly in tumor or tumor-associated cells. In particular, the therapeutic and diagnostic methods of the present invention include the use of a binding molecule, for example an antibody or immunospecific fragment thereof, which specifically binds to a lung tumor-associated polypeptide, variant polypeptide or fragment thereof.