Norman C Block

US Patent:

6429204, Aug 6, 2002

Filed:

Apr 3, 2000

Appl. No.:

09/542402

Inventors:

Lorne M. Golub - Smithtown NY
Thomas F. McNamara - Morristown NY
Nungavaram S. Ramamurthy - Smithtown NY
Hsi-Ming Lee - Setauket NY
Sanford Simon - Stony Brook NY
Balakrishna L. Lokeshwar - Miami FL
Marie G. Selzer - Fort Lauderdale FL
Norman L. Block - Miami FL

Assignee:

University of Miami - Miami FL

International Classification:

A61K 3165

US Classification:

514152, 514153

Abstract:

The invention is a method of inhibiting a sarcoma, such as Kaposis sarcoma, in a mammal. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3. ).

US Patent:

61002488, Aug 8, 2000

Filed:

Jan 15, 1998

Appl. No.:

9/007645

Inventors:

Lorne M. Golub - Smithtown NY
Thomas F. McNamara - Port Jefferson NY
Nungavaram S. Ramamurthy - Smithtown NY
Hsi-Ming Lee - Setauket NY
Sanford Simon - Stony Brook NY
Balakrishna L. Lokeshwar - Miami FL
Marie G. Selzer - Fort Lauderdale FL
Norman L. Block - Miami FL

International Classification:

A01N 3718

US Classification:

514152

Abstract:

The invention is a method of inhibiting cancer growth, by inhibiting cellular proliferation, invasiveness, or metastasis, or by inducing cytotoxicity against cancer in mammals. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.

US Patent:

58376968, Nov 17, 1998

Filed:

Jan 15, 1997

Appl. No.:

8/783655

Inventors:

Lorne M. Golub - Smithtown NY
Thomas F. McNamara - Port Jefferson NY
Nungavaram S. Ramamurthy - Smithtown NY
Hsi-Ming Lee - Setauket NY
Sanford Simon - Stony Brook NY
Balakrishna L. Lokeshwar - Miami FL
Marie G. Selzer - Fort Lauderdale FL
Norman L. Block - Miami FL

Assignee:

The Research Foundation of State University of New York - Albany NY
University of Miami - Miami FL

International Classification:

A01N 3718
A61K 3165

US Classification:

514152

Abstract:

The invention is a method of inhibiting cancer growth, including cellular proliferation, invasiveness, or metastasis in mammals. The method employs 6-demethyl-6-deoxy-4-dedimethylaminotetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.

US Patent:

20180250358, Sep 6, 2018

Filed:

Nov 21, 2017

Appl. No.:

15/820079

Inventors:

- Miami FL, US
- Washington DC, US
Norman Block - Hollywood FL, US
Samirah Gomes - Miami Beach FL, US

International Classification:

A61K 38/16

Abstract:

Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion injury in a subject in need may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In additional embodiment, a method of promoting vasculogenesis in a mammal may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In a further embodiment, a method of promoting differentiation of mesenchymal stem cells into endothelial cells may involve contacting mesenchymal stem cells with at least one GHRH agonist peptide.

US Patent:

20140179604, Jun 26, 2014

Filed:

Dec 23, 2013

Appl. No.:

14/138391

Inventors:

- WASHINGTON DC, US
- MIAMI FL, US
Norman L. BLOCK - Hollywood FL, US
Samirah A. GOMES - Miami Beach FL, US

Assignee:

U.S.A., REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS - WASHINGTON DC
UNIVERSITY OF MIAMI - MIAMI FL

International Classification:

A61K 38/25
A61K 38/16

US Classification:

514 112

Abstract:

Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion injury in a subject in need may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In additional embodiment, a method of promoting vasculogenesis in a mammal may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In a further embodiment, a method of promoting differentiation of mesenchymal stem cells into endothelial cells may involve contacting mesenchymal stem cells with at least one GHRH agonist peptide.