Norman J Moore

US Patent:

6548309, Apr 15, 2003

Filed:

Mar 19, 1998

Appl. No.:

09/044677

Inventors:

Norman James Moore - North Berwick ME
Vincent Anthony Sy - Cumberland Center ME

Assignee:

Binax, Inc. - Portland ME

International Classification:

G01N 33553

US Classification:

436500, 436510, 436524, 436528, 436530, 436 20, 436 21, 436808, 436814, 436818, 436825, 436514, 435 4, 435 737, 435 12, 435 30, 435 32, 435 34, 435 38, 604 1

Abstract:

In qualitative or quantitative assays which employ a test device comprising a test strip pretreated for detection of a specified target analyte dissolved in a liquid medium, the presence of solid, semisolid and/or colloidal materials in the liquid medium may interfere with the assay results. The present invention involves collecting the sample from a flowing or quiescent pool of liquid also containing solid, semisolid or colloidal material with a swab comprised of a handle and a mass of fibrous material or foamed, open cell material which, when immersed in and thoroughly wetted by the liquid, entraps solid, semisolid and/or colloidal material and delivers only the liquid to the sample receiving zone of the test strip.

US Patent:

6727073, Apr 27, 2004

Filed:

Nov 19, 1999

Appl. No.:

09/443211

Inventors:

Norman Moore - North Berwick ME
Phillip I. Tarr - Seattle WA

Assignee:

Binax, Inc. - Portland ME

International Classification:

G01N 3353

US Classification:

435 732, 435 737, 435 794, 435 287, 4352878, 435 30, 436518, 436526, 436536, 436538, 436161, 436810

Abstract:

A method for determining and diagnosing inflammatory enteric disease using an immunochromatographic test device having a multiplicity of test zones. The method tests for the presence of at least one enteric pathogen and at least one of certain inflammatory enteric disease markers. The enteric pathogens tested for can be any number of enteric pathogens such as the pathogens O157, Campylobacter, Salmonella, Listeria, Shigella, and Yersinia. The inflammatory enteric disease markers tested for are fecal lactoferrin, a bacteria marker, a virus marker, and a protozoa marker. Positive results for any one of the pathogens indicates that pathogen as the cause of the inflammatory enteric disease. Positive results for fecal lactoferrin indicate an inflammatory condition of the intestines. Positive results for the bacteria, virus, protozoa markers indicate respectively a bacterial, viral, or protozoan cause of infection as the cause of the disease. Liquid fecal sample is mixed with a mixture containing antibodies to the pathogens and the markers.

US Patent:

6824997, Nov 30, 2004

Filed:

Sep 16, 1999

Appl. No.:

09/397110

Inventors:

Norman James Moore - North Berwick ME
Mary Kathleen Fent - Cumberland Center ME
Vladimir Andrei Koulchin - Portland ME
Elena Valentin Molokova - Portland ME

Assignee:

BINAX, Inc. - Portland ME

International Classification:

A61K 39085

US Classification:

435 734, 435 71, 435 732, 435 792, 435 794, 435 5, 435 699, 435419, 435468, 435 697, 435 698, 435101, 435 4, 536127, 536123, 5361231, 536124, 536126, 4241931, 4241941, 4241971, 4242341, 4242371, 4242411, 4242441, 436518, 436530, 436531, 436501, 436 63, 436514, 530403, 530405, 530406, 530408, 530409, 422 50, 422 55, 422 57, 422 61, 422101

Abstract:

A process is disclosed for obtaining a C-polysaccharide cell wall antigen containing not more than about 10% protein from bacteria. The antigen thus obtained is conjugated to a spacer molecule, and the free end of the latter is then conjugated to a chromatographic affinity column. The column is then utilized to purify raw antibodies to bacteria, thereby producing antigen-specific antibodies. A portion of such antibodies is conjugated to a labeling agent which displays a visible color change upon reaction of the antibodies with their antigenic binding partner and embedded in a first zone of an immunochromatographic assay device. Another portion of such antibodies is bound to the reaction zone of the device which has a view window. When a liquid sample, such as patient urine, cerebrospinal fluid or blood is applied to the first zone, the conjugate of antibodies and labeling agent and the sample move along a flow strip of bibulous material to the reaction zone wherein, if the sample contains or its cell wall antigen, a sandwich is formed among the labeled conjugate, the antigen and the bound antibodies and a color change is observed. The immunochromatographic assay thus performed is completed within about 15 minutes.

US Patent:

20050148039, Jul 7, 2005

Filed:

Nov 16, 2004

Appl. No.:

10/989050

Inventors:

Norman Moore - North Berwick ME, US
Mary Fent - Cumberland Center ME, US
Vladimir Koulchin - Portland ME, US
Elena Molokova - Portland ME, US

International Classification:

C07K016/12
G01N033/554
G01N033/569
C08B037/00

US Classification:

435007320, 530388400, 536053000

Abstract:

Disclosed is a cell wall C-polysaccharide antigen of which contains not more than 10% by weight of protein, and preferably less which has been purified with 0.1 N Na OH prior to deproteinizing. Also disclosed are polyvalent antibodies raised against which have been affinity purified by passing them over a chromatographic affinity matrix to which is coupled the purified and at least partially deproteinized antigen to render them antigen-specific.

US Patent:

20070265433, Nov 15, 2007

Filed:

Apr 26, 2007

Appl. No.:

11/740738

Inventors:

Norman Moore - North Berwick ME, US
Mary Fent - Cumberland Center ME, US
Vladimir Koulchin - Portland ME, US
Elena Molokova - Portland ME, US

Assignee:

Binax, Inc. - Portland ME

International Classification:

C07K 16/00
C07H 3/00

US Classification:

530387900, 536123100

Abstract:

Disclosed is a cell wall C-polysaccharide antigen of which contains not more than 10% by weight of protein, and preferably less which has been purified with 0.1N Na OH prior to deproteinizing. Also disclosed are polyvalent antibodies raised against which have been affinity purified by passing them over a chromatographic affinity matrix to which is coupled the purified and at least partially deproteinized antigen to render them antigen-specific.

US Patent:

20080081347, Apr 3, 2008

Filed:

Jun 12, 2007

Appl. No.:

11/761628

Inventors:

Norman Moore - North Berwick ME, US
Myron Whipkey - Portland ME, US
James Welch - Portland ME, US

Assignee:

Binax, Inc. - Portland ME

International Classification:

G01N 33/554

US Classification:

435007320

Abstract:

A qualitative and quantitative EIA for detecting in water samples is disclosed. Critical to the disclosed levels of sensitivity of these EIA's is the use of antigen-specific antibodies to the target antigen that have been rendered antigen-specific by affinity purification on a chromatographic column, which antibodies and their purification are described in detail in parent application Ser. No. 09/139,720 filed Aug. 25, 1998.

US Patent:

20080096236, Apr 24, 2008

Filed:

Jun 11, 2007

Appl. No.:

11/761255

Inventors:

Vladimir Koulchin - Portland ME, US
Norman Moore - North Berwick ME, US
Elena Molokova - Portland ME, US
Mary Fent - Cumberland Center ME, US

Assignee:

Binax, Inc. - Portland ME

International Classification:

G01N 33/569
C07K 16/12
C12P 19/00

US Classification:

435007320, 435072000, 530389500

Abstract:

A process is disclosed for separating a carbohydrate antigen from a Gram-positive or Gram-negative bacteria in a purified form that contains no more than 10% protein. The separated antigen is coupled to an affinity column, over which polyclonal antibodies to the same bacteria are chromatographed and recovered in a purified form that exhibits high specificity and sensitivity in immunoassays for the raw carbohydrate antigen corresponding to the purified antigen on the column. A particularly preferred form of rapid immunochromatographic assay employing the purified antibodies, which assay is very useful as an aid to rapid diagnosis of diseases caused by bacteria, is disclosed.

US Patent:

20080241191, Oct 2, 2008

Filed:

Oct 31, 2007

Appl. No.:

11/982410

Inventors:

Norman James Moore - North Berwick ME, US
Mary Kathleen Fent - Cumberland Center ME, US
Vladimir Andrei Koulchin - Portland ME, US
Elena Valentin Molokova - Portland ME, US

Assignee:

Binax, Inc. - Portland ME

International Classification:

A61K 39/09
C07K 16/12

US Classification:

4242441, 5303895

Abstract:

Disclosed is a cell wall C-polysaccharide antigen of which contains not more than 10% by weight of protein, and preferably less which has been purified with 0.1N NaOH prior to deproteinizing. Also disclosed are polyvalent antibodies raised against which have been affinity purified by passing them over a chromatographic affinity matrix to which is coupled the purified and at least partially deproteinized antigen to render them antigen-specific.