Dr. Nelson graduated from the Louisiana State University School of Medicine at New Orleans in 1986. He works in Macon, GA and specializes in Ophthalmology and General Surgery. Dr. Nelson is affiliated with Coliseum Medical Centers and Medical Center Navicent Health.
Dr. Nelson graduated from the University of Illinois, Chicago College of Medicine in 1953. He works in Tarzana, CA and specializes in Dermatology. Dr. Nelson is affiliated with Providence Tarzana Medical Center.
The present specification provides novel intermediates and novel processes for the synthesis of Thromboxane B. sub. 2 11a-homo-11a-oxa-PGF. sub. 2. alpha. ), its 15-epimer, and various carboxyl derivatives thereof. In particular, there are disclosed various bicyclic tetrahydrofuran-containing lactones useful in the above processes, and corresponding acyclic lactones.
This invention is a group of 3-oxa PGE-type compounds, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition and platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
Prostaglandin analogs wherein the C-2 carboxy is replaced by an aminomethyl or (substituted amino)methyl are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as the prostaglandins.
Gordon L. Bundy - Kalamazoo MI Norman A. Nelson - Galesburg MI
Assignee:
The Upjohn Company - Kalamazoo MI
International Classification:
C07C17700
US Classification:
260410
Abstract:
This invention relates to a group of cis-4,5-didehydro-11-deoxy-PG. sub. 1 analogs having variable chain length, optional methyl substitution in the methyl-terminated side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including ulcer treatment, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
This invention is a group of PGF. sub. 1. sub. beta. -type and PGF. sub. 2. sub. beta. -type oxa-phenylene compounds, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including inhibition of platelet aggregation, treatment of asthma, labor inducement at term, and cervical dilation.
Processes for preparing 5,6-dihydro-prostacyclin analogs, which are 9-deoxy-6,9-cyclic ethers of prostaglandin F. sub. 1. alpha. -type compounds, illustrated, for example, by a compound of the formula ##STR1## wherein. about. indicates alpha or beta configuration; including the products and intermediates produced therein, said products having pharmacological utility.
Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.