Ohyun H Kwon from 10968 Wilkins Ave PH 5, Los Angeles, CA 90024, age 52

Generation Of Skeletal Diversity Within A Combinatorial Library
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US Patent:

20040214232, Oct 28, 2004
Filed:

Aug 14, 2003
Appl. No.:

10/640834
Inventors:

Martin Burke - Cambridge MA, US
Eric Berger - Concord MA, US
Ohyun Kwon - Los Angeles CA, US
Seung Park - Arlington MA, US
Stuart Schreiber - Boston MA, US
International Classification:

G01N033/53
G01N033/543
US Classification:

435/007100, 436/518000
Abstract:

The present invention provides a method of synthesizing a library of chemical compounds with skeletal diversity. Two approaches are used to create skeletal diversity within a library of chemical compounds: (1) the “branching pathways” (or reagent-based) approach; and (2) the “folding pathways” (or substrate-based) approach. Upon exposure to certain reaction conditions the members of the library undergo unique transformations into a diverse collection of molecular skeletons, which can be functionalized and derivatized further to generate a large collection of unique, natural product-like compounds. A furan-based library synthesized using the folding pathways approach is provided, and a polycyclic library created using the braching pathways approach is also provided. The invention also provides materials, reagents, intermediates, and kits useful in the practice of the inventive method as well as method for screening the inventive compounds.

Inhibitors Of Protein Prenyltransferases
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US Patent:

20100063114, Mar 11, 2010
Filed:

Mar 22, 2007
Appl. No.:

12/293993
Inventors:

Fuyuhiko Tamanoi - Los Angeles CA, US
Ohyun Kwon - Los Angeles CA, US
Masaru Watanabe - Iwate, JP
Hannah Fiji - Fontana CA, US
Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:

A61K 31/44
C07D 211/78
C07D 207/22
C07D 207/48
A61K 31/40
A61P 35/00
A61P 35/02
US Classification:

514356, 546322, 548531, 548542, 514423
Abstract:

The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of GGTase I. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.

Inhibitors Of Protein Prenyltransferases
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US Patent:

20110178138, Jul 21, 2011
Filed:

Jul 28, 2008
Appl. No.:

13/056077
Inventors:

Ohyun Kwon - Los Angeles CA, US
Fuyuhiko Tamanoi - Los Angeles CA, US
Hanna Fiji - Los Angeles CA, US
Masaru Watanabe - Iwate, JP
Assignee:

The Regents of the University of California - Oakland CA
International Classification:

A61K 31/4418
C07D 207/48
C07D 211/96
A61K 31/40
C12N 5/071
C12Q 1/48
US Classification:

514350, 548531, 546322, 546298, 514423, 514356, 435375, 435 15
Abstract:

The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of protein prenyltransferases including GGTase I and/or RabGGTase. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.

Inhibitors Of Protein Prenyltransferases
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US Patent:

20130102639, Apr 25, 2013
Filed:

Sep 13, 2012
Appl. No.:

13/614789
Inventors:

Ohyun Kwon - Los Angeles CA, US
Fuyuhiko Tamanoi - Los Angeles CA, US
Hannah Fiji - Fontana CA, US
Masaru Watanabe - Yahaba, JP
Assignee:

The Regents of the University of California - Oakland CA
International Classification:

C07D 211/96
C07D 207/48
US Classification:

514347, 548531, 514423, 546294
Abstract:

The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of protein prenyltransferases including GGTase I and/or RabGGTase. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.

Chemical Inhibitors Of Cholesterol Biosynthesis And Venous Angiogenesis
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US Patent:

20130289073, Oct 31, 2013
Filed:

Jan 17, 2012
Appl. No.:

13/979566
Inventors:

Ohyun Kwon - Los Angeles CA, US
Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:

A61K 31/4418
A61K 31/4436
C07D 409/04
C07D 211/96
A61K 45/06
US Classification:

514336, 546315, 514355, 435375, 506 10
Abstract:

This invention relates, e.g., to a compound, aplexone, and pharmaceutically acceptable salts and solvates, and functional variants, thereof. Methods of using the compounds and pharmaceutical compositions comprising them, e.g. to inhibit angiogenesis and to reduce cellular cholesterol levels, are also included.

Small Molecules For Endothelial Cell Activation
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US Patent:

20130310417, Nov 21, 2013
Filed:

Feb 23, 2012
Appl. No.:

13/981912
Inventors:

Daniel Cruz - Los Angeles CA, US
Ohyun Kwon - Los Angeles CA, US
Assignee:

The Regents of the University fo California - Oakland CA
International Classification:

G01N 33/50
C07D 471/04
US Classification:

514300, 435 34, 506 9, 546122, 506 25
Abstract:

The present invention provides small molecules for endothelial cell activation and compositions thereof and methods of making and using the same.

Anti-Arrhythmicity Agents
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US Patent:

20170362173, Dec 21, 2017
Filed:

Dec 15, 2015
Appl. No.:

15/536314
Inventors:

- Oakland CA, US
Ohyun KWON - Los Angeles CA, US
Jie HUANG - Los Angeles CA, US
Hirohito SHIMIZU - Los Angeles CA, US
Kui LU - Los Angeles CA, US
Johann SCHREDELSEKER - Los Angeles CA, US
Yi Chiao FAN - Los Angeles CA, US
Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:

C07D 207/48
A61K 38/17
C12N 15/113
A61K 31/40
A61K 48/00
A61K 31/7088
Abstract:

Agents, compositions, and methods for regulating cardiac rhythmicity are disclosed.

Nanodrug Targeting Protein Geranylgeranylation
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US Patent:

20140341979, Nov 20, 2014
Filed:

Jul 30, 2014
Appl. No.:

14/447176
Inventors:

- Oakland CA, US
Jie Lu - Los Angeles CA, US
Kohei Yoshimura - Kawasaki, JP
Ohyun Kwon - Los Angeles CA, US
Hannah Fiji - Fontana CA, US
Masaru Watanabe - Yahaba, JP
International Classification:

A61K 9/127
A61K 31/40
A61K 45/06
A61K 31/4418
US Classification:

424450, 514355, 514423, 514424, 435184, 705 2
Abstract:

The present invention relates, for example, to a liposome, which can be a basic liposome, a transferrin-conjugated liposome, or a pH-sensitive liposome, which encapsulates a compound that specifically inhibits the activity of a protein prenyltransferase, such as a RabGGTase and/or a GGTase I. The liposomes can be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.