Pacifico A Principe

US Patent:

39898415, Nov 2, 1976

Filed:

Sep 30, 1974

Appl. No.:

5/510850

Inventors:

Eric T. Stiller - Sarasota FL
Seymour D. Levine - North Brunswick NJ
Pacifico A. Principe - South River NJ
Patrick A. Diassi - Westfield NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 2700

US Classification:

424317

Abstract:

Novel fluorene-2-acetic acid derivatives and methods for preparing these derivatives are provided. Inflammatory conditions may be treated by administering these novel compounds. Additionally, it has been found that the treatment of inflammatory conditions is a new use for certain known compounds; specifically, fluorene-2-acetic acid and its 7-halo, 7-amino, and 7-nitro derivatives.

US Patent:

42050685, May 27, 1980

Filed:

May 18, 1978

Appl. No.:

5/906906

Inventors:

Richard B. Sykes - Rocky Hill NJ
J. Scott Wells - Ringoes NJ
Pacifico A. Principe - South River NJ
Wen C. Liu - Princeton Junction NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 3764

US Classification:

424117

Abstract:

A substance which inhibits the enzyme. beta. -lactamase, produced by a wide range of microorganisms, is obtained when species of the microorganism Micromonospora are cultivated under aerobic fermentation conditions and this inhibitor can be isolated from the fermentation medium by extraction. This substance, denominated EM4615, is useful to enhance the effectiveness of. beta. -lactam antibiotics such as penicillins and cephalosporins.

US Patent:

40524361, Oct 4, 1977

Filed:

Aug 17, 1976

Appl. No.:

5/715033

Inventors:

Eric T. Stiller - Sarasota FL
Seymour D. Levine - North Brunswick NJ
Pacifico A. Principe - South River NJ
Patrick A. Diassi - Westfield NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07C 6976
A61K 31235

US Classification:

560 52

Abstract:

Fluorene-2-glyoxylic acid, 7-substituted derivatives thereof, and ester derivatives thereof are disclosed as useful for the treatment of inflammatory conditions.