Palaniappan Kulanthaivel

US Patent:

6793925, Sep 21, 2004

Filed:

Aug 7, 2003

Appl. No.:

10/636376

Inventors:

Palaniappan Kulanthaivel - Carmel IN
Matthew David Belvo - Greenfield IN
James William Martin - Coatesville IN
Douglas Joseph Zeckner - Greenwood IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 3900

US Classification:

4241841, 4242341, 4242601, 514 11, 514 15, 530300, 530317, 530328

Abstract:

The invention relates to pseudomycin natural products including pseudomycins Aâ and Bâ, methods for making such pseudomycins, and methods employing antifungal activity of these pseudomycins. NMR and mass spectrometry indicate formula (I) for pseudomycin Aâ. NMR and mass spectrometry indicate formula (II) for pseudomycin Bâ.

US Patent:

6951840, Oct 4, 2005

Filed:

Aug 14, 2002

Appl. No.:

10/219218

Inventors:

Matthew David Belvo - Greenfield IN, US
Adam Joseph Kreuzman - Greenwood IN, US
Palaniappan Kulanthaivel - Carmel IN, US
Tim Allen Smitka - Indianapolis IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K038/14
A16K038/16

US Classification:

514 8, 530317, 530322

Abstract:

Provided are novel lipoglycopeptides exhibiting bacterial signal peptidase inhibitory activity. Also provided are actinomycete strains that produce these lipoglycopeptides, methods of producing such lipoglycopeptides by culturing these strains, pharmaceutical compositions comprising these lipoglycopeptides, and methods of treating bacterial infections comprising contacting bacteria susceptible to treatment with the present bacterial signal peptidase inhibitor lipoglycopeptides. These lipoglycopeptides are useful in human and veterinary medicine.

US Patent:

6630147, Oct 7, 2003

Filed:

Oct 15, 2001

Appl. No.:

09/958995

Inventors:

Palaniappan Kulanthaivel - Carmel IN
Matthew David Belvo - Greenfield IN
James William Martin - Coatesville IN
Thomas John Perun - Indianapolis IN
Douglas Joseph Zeckner - Greenwood IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 3900

US Classification:

4241841, 4242341, 4242601, 514 11, 514 15, 530300, 530317, 530328

Abstract:

The invention relates to pseudomycin natural products including pseudomycins Aâ and Bâ, methods for making such pseudomycins, and methods employing antifungal activity of these pseudomycins. NMR and mass spectrometry indicate a formula for pseudomycin Aâ of: NMR and mass spectrometry indicate a formula for pseudomycin Bâ of:.