VA Medical Center Emergency Department 1101 Veterans Dr, Lexington, KY 40502 (859)2334511 (phone), (859)2333993 (fax)
Education:
Medical School University of Kentucky College of Medicine Graduated: 2002
Procedures:
Electrocardiogram (EKG or ECG)
Conditions:
Bronchial Asthma Chronic Renal Disease Fractures, Dislocations, Derangement, and Sprains Otitis Media Pneumonia
Languages:
English
Description:
Dr. Holland graduated from the University of Kentucky College of Medicine in 2002. She works in Lexington, KY and specializes in Emergency Medicine and Internal Medicine.
Us Patents
Gnk Interacting Amino Acid Decarboxylase And Methods Of Use Thereof
The present invention discloses a novel polypeptide that contains an amino acid decarboxylase domain, and is a substrate for caspase-3. Nucleic acids that encode the novel polypeptide and antibodies to the polypeptide are also part of the present invention. Methods of using the polypeptide, the nucleic acids and antibodies are also provided.
Process For Discrimination Of Nucleic Acid Sequence Variants
A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay.
David H. Gelfand - Oakland CA, US Pamela M. Holland - Seattle WA, US Randall K. Saiki - Richmond CA, US Robert M. Watson - Berkeley CA, US
Assignee:
Roche Molecular Systems, Inc. - Pleasanton CA
International Classification:
C12Q 1/68 C12P 19/34
US Classification:
435 6, 435 912
Abstract:
A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification, assay.
Death Associated Kinase Containing Ankyr In Repeats (Dakar) And Methods Of Use
This invention relates to DAKAR, a new member of the serine/threonine kinase family, methods of making such polypeptides, and to methods of using them to treat conditions associated with apoptosis and epithelial proliferation and differentiation, as well as methods to identify compounds that alter DAKAR-associated cellular activities.
David Gelfand - Oakland CA, US Pamela Holland - Seattle WA, US Randall Saiki - Richmond CA, US Robert Watson - Berkeley CA, US
International Classification:
C12Q 1/68 C12P 19/34
US Classification:
435006000, 435091200
Abstract:
A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay.
David Gelfand - Oakland CA, US Pamela Holland - Seattle WA, US Randall Saiki - Richmond CA, US Robert Watson - Berkeley CA, US
International Classification:
C12Q 1/68 C12P 19/34
US Classification:
435006000, 435091200
Abstract:
A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification, assay.
Pamela M. Holland - Seattle WA, US Julia C. Piasecki - Seattle WA, US Christopher A. Benetatos - Malvern PA, US Srinivas K. Chunduru - Malvern PA, US Mark A. McKinlay - Malvern PA, US
Assignee:
TETRALOGIC PHARMACEUTICALS - Malvern PA AMGEN INC. - Thousand Oaks CA
International Classification:
A61K 39/395 A61P 35/04 A61K 38/17
US Classification:
4241331, 4241301, 4241421, 514 193, 4241741
Abstract:
The invention provides methods for inducing apoptosis, comprising treatment of a patient with a TNFα inhibitor as well as with an IAP inhibitor and a TRAIL receptor agonist. The methods ameliorate the risk of unwanted effects, thereby resulting in an improved therapeutic index for IAP inhibitors in combination with a TRAIL receptor agonist.
Nucleic Acid Detection By The 5'-3'Exonuclease Activity Of Polymerases Acting On Adjacently Hybridized Oligonucleotides
David H. Gelfand - Oakland CA Pamela M. Holland - Seattle WA Randall K. Saiki - Richmond CA Robert M. Watson - Berkeley CA
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
C12Q 168 C12P 1934
US Classification:
435 6
Abstract:
A process of detecting a target nucleic acid using labeled oligonucleotides which uses the 5' to 3' nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and thus releasing labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay.
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oswego nyLPN at OH 53 yrs old who would really like to be 25 again, then again who wouldn't? mother of 2 great kids both on their own. at least i think they are LOL