Pamela L Pennington

US Patent:

55020615, Mar 26, 1996

Filed:

Sep 26, 1994

Appl. No.:

8/312491

Inventors:

Kwan Y. Hui - Carmel IN
Charles D. Jones - Indianapolis IN
Louis N. Jungheim - Indianapolis IN
Pamela A. Pennington - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 3702
C07D21340
C07D29526
C07D30336
C07C 4911
C07C 31125
C07C25138
C07C27518

US Classification:

514311

Abstract:

The present invention provides HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.

US Patent:

59943700, Nov 30, 1999

Filed:

Apr 22, 1998

Appl. No.:

9/064548

Inventors:

Henry Uhlman Bryant - Indianapolis IN
Charles David Jones - Indianapolis IN
Pamela Ann Pennington - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31445
A61K 3155
C07D21106
C07D20708

US Classification:

514319

Abstract:

The present invention provides a class of substituted indene compounds and their pharmaceutically acceptable salts which possess selective estrogen receptor modulator (SERM) activity and are thus useful in the treatment of osteoporosis and cardiovascular disease, particularly hyperlipidemia in women. The compounds possess the structure ##STR1## in which R. sup. 1 is hydrogen, hydroxy, alkoxy, phenylcarbonyloxy, alkylcarbonyloxy, or alkylsulfonyloxy. R. sup. 2 is hydrogen, hydroxy, halo, alkoxy, phenylcarbonyloxy, alkylcarbonyloxy, or alkylsulfonyloxy. R. sup. 3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexa-methyleneimino, and n is 2 or 3. The dashed line bond between the carbon atoms at positions 1 and 2 of the indene nucleus represent an optional double bond with the proviso that when the double bond is absent, the parenthetic hydroxy group at position 1 is present and vice versa. Certain 2,3-dihydro-1H-indene precursors to the disclosed indene compounds also possess SERM activity and are useful for the same purposes.