Patricia L Black

US Patent:

49943839, Feb 19, 1991

Filed:

Aug 29, 1989

Appl. No.:

7/400306

Inventors:

Marian N. Beremand - Peoria IL
Patricia J. Black - Peoria IL

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C12R 177
C12P 500

US Classification:

435166

Abstract:

Mutants blocked or altered in the production of the trichothecene mycotoxin T-2 have been selected following UV mutagenesis of Fusarium sporotrichioides NRRL 3299. One mutant, NRRL 18339, accumulates the rare trichothecenes dideacetylcalonectrin and deacetylcalonectrin. The second mutant, NRRL 18340, accumulates trichodiene, the first intermediate on the trichothecene biosynthetic pathway. These compounds are useful toxins or toxic precursors for the production of or investigation of immunotoxins for cancer therapy.

US Patent:

48807478, Nov 14, 1989

Filed:

Mar 28, 1988

Appl. No.:

7/173910

Inventors:

Marian N. Beremand - Peoria IL
Patricia J. Black - Peoria IL

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C12N 114
C12N 177
C12P 500
C12P 102

US Classification:

435254

Abstract:

Mutants blocked or altered in the production of the trichothecene mycotoxin T-2 have been selected following UV mutagenesis of Fusarium sporotrichioides NRRL 3299. One mutant, NRRL 18339, accumulates the rare trichothecenes and dideacetylaclonectrin and deacetylcalonectrin. The second mutant, NRRL 18340, accumulates trichodiene, the first intermediate on the trichothecene biosynthetic pathway. These compounds are useful toxins or toxic precursors for the production of or investigation of immunotoxins for cancer therapy.